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EGFRvIII Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
EGI-HF2H7 Human FITC-Labeled Human EGFRvIII Protein, His Tag
EGI-H52H4 Human Human EGFRvIII Protein, His Tag
EGR-H82E0 Human Biotinylated Human EGFRvIII Protein, Avitag™,His Tag

EGFRvIII Molecule Synonym Name


EGFRvIII Molecule Background

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer. The type III EGF deletion-mutant receptor (EGFRvIII) is the most common mutation and was first identified in primary human glioblastoma tumors; EGFR gene amplification is correlated with the structural rearrangement of the gene. The EGFRvIII gene has an in-frame deletion of 801 base pairs, corresponding to exons 2–7 in the mRNA, resulting in the deletion of amino acids 30-297 in the extracellular domain and the generation of a glycine at the fusion point

EGFRvIII References

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