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HGF

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Cat. No. Species Product Description Structure Purity Feature
HGF-H5253 Human Human HGF Protein, Fc Tag (MALS verified)
HGF-H5253-structure
HGF-H5253-sds
HGF-H5253-elisa_1
HGF-H52H3 Human Human HGF Protein, His Tag (MALS verified)
HGF-H52H3-structure
HGF-H52H3-sds
HGF-H52H3-elisa_1
HGF-H52H3-elisa_2

Part of Bioactivity data

HGF-H52H3-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human HGF R Protein, Fc Tag (Cat. No. MET-H5256) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human HGF Protein, His Tag (Cat. No. HGF-H52H3) with an affinity constant of 75.2 pM as determined in a SPR assay (Biacore 8K) (QC tested).

HGF-H52H3-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human HGF R, Fc Tag (Cat. No. MET-H5256) on Protein A Biosensor, can bind Human HGF, His Tag (Cat. No. HGF-H52H3) with an affinity constant of 3.29 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

HGF,HPTA,SF

Background

Hepatocyte growth factor (HGF)  is a paracrine cellular growth, motility and morphogenic factor. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. In addition, HGF has been implicated in a variety of cancers, including of the lungs, pancreas, thyroid, colon, and breast.

Clinical and Translational Updates

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