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Your Position: Home > IL-2 R beta & IL-2 R gamma

IL-2 R beta & IL-2 R gamma

Brief Information

Name:Interleukin-2 receptor beta chain
Target Synonym:IL2RB,IMD63,IL-2RB,p75,CD122,Interleukin 2 Receptor Subunit Beta,Interleukin-15 Receptor Subunit Beta,Interleukin 15 Receptor, Beta,Interleukin 2 Receptor, Beta,IL-2R Subunit Beta,CD122 Antigen,P70-75,IL15RB,High Affinity IL-2 Receptor Beta Subunit,Interleukin-2 Receptor beta Subunit,Interleukin-2 receptor subunit beta,IL-2 receptor subunit beta,High affinity IL-2 receptor subunit beta
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:14
Lastest Research Phase:Phase 3 Clinical

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IL-2 R beta & IL-2 R gamma Molecule Synonym Name

IL-2 R beta & IL-2 R gamma,IL-2RB & IL-2RG

IL-2 R beta & IL-2 R gamma Molecule Background

Both Interleukin-2 receptor subunit beta and Interleukin-2 receptor subunit gamma are receptor for interleukin-2. Common subunit for the receptors for a variety of interleukins. Interacts with SHB upon interleukin stimulation. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.

IL-2 R beta & IL-2 R gamma References

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Bempegaldesleukin BMS-986321; ONO-7911; NKTR-214 Phase 3 Clinical Nektar Therapeutics Coronavirus Disease 2019 (COVID-19); Melanoma; Glioma; Lymphoma; Sarcoma, Ewing; Brain Neoplasms; Neuroblastoma; Prostatic Neoplasms, Castration-Resistant; Urinary Bladder Neoplasms; Ependymoma; Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Rhabdomyosarcoma; Head and Neck Neoplasms; Leukemia; Medulloblastoma; Solid tumours Details
Nanrilkefusp alfa SO-C101; RLI-15; CYP-0150; SOT-101 Phase 2 Clinical Microsatellite instability-high cancer; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Melanoma; Uterine Cervical Neoplasms; Carcinoma, Squamous Cell; Colorectal Neoplasms; Thymus Neoplasms; Urinary Bladder Neoplasms; Mesothelioma; Prostatic Neoplasms, Castration-Resistant; Thyroid Diseases; Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms; Carcinoma, Renal Cell; Carcinoma, Merkel Cell; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Anus Neoplasms; Ovarian Neoplasms; Biliary Tract Neoplasms Details
GI-101 SIM-323; SIM323; GI-101 Phase 2 Clinical GI Innovation Inc Solid tumours; Carcinoma, Merkel Cell; Carcinoma, Renal Cell; Vaginal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Neoplasms; Urinary Bladder Neoplasms; Sarcoma; Vulvar Neoplasms; Colorectal Neoplasms; Esophageal Squamous Cell Carcinoma; Melanoma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Neoplasm Metastasis Details
THOR-707 THOR-707; SAR-444245 Phase 2 Clinical Synthorx Inc Oropharyngeal Neoplasms; Melanoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Esophageal adenocarcinoma; Carcinoma, Squamous Cell; Esophageal Squamous Cell Carcinoma; Colorectal Neoplasms; Intestinal Neoplasms; Mesothelioma; Skin Neoplasms; Lymphoma, Large B-Cell, Diffuse; Hodgkin Disease; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Head and Neck Neoplasms Details
IPH-6501 IPH-6501; IPH-65 Phase 2 Clinical Innate Pharma SA Neoplasms; Lymphoma, Non-Hodgkin Details
IAP-0971 IAP-0971 Phase 2 Clinical SunHo (China) BioPharmaceutical Co Ltd Solid tumours; Neoplasms; Urinary Bladder Neoplasms Details
TransCon IL-2 β/γ Phase 2 Clinical Ascendis Pharma A/S Head and Neck Neoplasms; Solid tumours; Ovarian Neoplasms; Neoplasm Metastasis Details
MDNA-11 MDNA-11; MDNA11 Phase 2 Clinical Medicenna Therapeutics Corp Triple Negative Breast Neoplasms; Melanoma; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Fallopian Tube Neoplasms; Endometrial Neoplasms; Carcinoma, Squamous Cell; Peritoneal Neoplasms; Mesothelioma; Urinary Bladder Neoplasms; Skin Neoplasms; Solid tumours; Carcinoma, Ovarian Epithelial; Stomach Neoplasms; Carcinoma, Merkel Cell; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Esophageal Neoplasms; Gastrointestinal Diseases; Carcinoma, Basal Cell; Ovarian Neoplasms; Skin Melanoma Details
Simlukafusp alfa FAP-IL2v; RG-7461; aFAP-IL2v; RO-6874281; FAP-IL2v FP Phase 1 Clinical F. Hoffmann-La Roche Ltd Head and Neck Neoplasms; Solid tumours; Carcinoma, Renal Cell; Esophageal Neoplasms; Breast Neoplasms; Uterine Cervical Neoplasms; Melanoma Details
BJ-001(Boji Biomedical Technology) BJ-001 Phase 1 Clinical Boji Biomedical Technology (Hangzhou) Co Ltd Solid tumours; Communicable Diseases; Neoplasm Metastasis Details
STK-009 STK-009 Phase 1 Clinical Synthekine Inc Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lupus Nephritis; Lupus Erythematosus, Systemic; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell Details
FB-102 FB-102; FB102 Phase 1 Clinical Forte Biosciences Inc Alopecia Areata; Graft vs Host Disease; Vitiligo; Malabsorption Syndromes Details
NL-201 (Neoleukin Therapeutics) NL-201 Phase 1 Clinical Neoleukin Therapeutics Inc Solid tumours Details
Recombinant human interleukin 15(Beijing Kawin) Phase 1 Clinical Beijing Kawin Technology Share-Holding Co Ltd Solid tumours Details

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