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Fc epsilon RI alpha

Fc epsilon RI alpha Molecule Information

Name:IgE Fc receptor, alpha-subunit
Target Synonym:Fc Fragment Of IgE, High Affinity I, Receptor For; Alpha Polypeptide,FCE1A,IgE Fc receptor subunit alpha,Fc-epsilon RI-alpha,FCER1A,Fc Fragment Of IgE Receptor Ia,Fc Fragment Of IgE, High Affinity I, Receptor For,Alpha Polypeptide,Fc Epsilon Receptor Ia,F
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Approved

Fc epsilon RI alpha Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
FCA-H5259 Human Human Fc epsilon RI alpha Protein, Fc Tag (BLI verified)
FCA-H5259-structure
FCA-H5259-sds
FCA-H5228 Human Human Fc epsilon RI alpha Protein, His Tag
FCA-H5228-structure
FCA-H5228-sds
FCA-H5228-elisa_1

Fc epsilon RI alpha Part of Bioactivity data

FCA-H5259-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human Fc epsilon RI alpha, Fc Tag (BLI verified) (Cat. No. FCA-H5259) on AHC Biosensor, can bind Immunoglobulin E, Human Plasma with an affinity constant of 0.188 nM as determined in BLI assay (ForteBio Octet Red96e) (QC Tested).

FCA-H5228-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human Fc epsilon RI alpha, His Tag (Cat. No. FCA-H5228) on AR2G Biosensor, can bind Immunoglobulin E, Human Plasma with an affinity constant of 2.71 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Fc epsilon RI alpha Molecule Synonym Name

FCER1A,FCE1A,FcERI

Fc epsilon RI alpha Molecule Background

High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A) is also known as Fc-epsilon RI-alpha (FcERI), IgE Fc receptor subunit alpha, FCE1A. FCER1A contains two Ig-like (immunoglobulin-like) domains. FCER1A binds to the Fc region of immunoglobulins epsilon and is a high affinity receptor. FCER1A is responsible for initiating the allergic response, which binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. FCER1A plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma.

Fc epsilon RI alpha References

Fc epsilon RI alpha Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Benzylpenicilloyl Polylysine Approved Allerquest Llc Pre-pen United States Anaphylaxis; Diagnostic agents s:14:"Allerquest Inc"; 1974-07-25 Anaphylaxis; Diagnostic agents Details

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