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IgG1 Fc

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Cat. No. Species Product Description Structure Purity Feature
IG1-HC2H3 Human Human IgG1 Fc (C103S, M135Y, S137T, T139E, H316K, N317F) Protein, His Tag-Cy5 (SPR verified)
IG1-HC2H3-sds
IG1-HF2H3 Human FITC-Labeled Human IgG1 Fc (C103S, M135Y, S137T, T139E, H316K, N317F) Protein, His Tag (MALS verified)
IG1-HF2H3-structure
IG1-HF2H3-sds
IG1-H52H5 Human Human IgG1 Fc (C103S, M135Y, S137T, T139E) Protein, His Tag
IG1-H52H5-structure
IG1-H52H5-sds
IG1-H52H7 Human Human IgG1 Fc (C103S, N180A) Protein, His Tag (MALS verified)
IG1-H52H7-structure
IG1-H52H7-sds
IG1-H52H6 Human Human IgG1 Fc (C103S, L117A, L118A) Protein, His Tag
IG1-H52H6-structure
IG1-H52H6-sds
IG1-H52H1 Human Human IgG1 Fc (C103S, D239E, L241E) Protein, Tag Free (MALS verified)
IG1-H52H1-structure
IG1-H52H1-sds
IG1-H52H8 Human Human IgG1 Fc (C103S, M135Y, S137T, T139E, H316K, N317F) Protein, His Tag
IG1-H52H8-structure
IG1-H52H8-sds
IG1-H52H9 Human Human IgG1 Fc (C103S, L117F, L118E, P214S) Protein, His Tag
IG1-H52H9-structure
IG1-H52H9-sds
IG1-H82E9 Human Biotinylated Human IgG1 Fc (C103S) Protein, Avitag™,His Tag (HPLC verified)
IG1-H82E9-structure
IG1-H82E9-sds
IG1-H82E9-hplc
IG1-M8211 Mouse Biotinylated Mouse IgG1 Fc protein, Avitag™ (MALS verified)
IG1-M8211-structure
IG1-M8211-sds
IG1-H52C9 Human Human IgG1 Fc (C103S) Protein, Flag Tag (MALS verified)
IG1-H52C9-structure
IG1-H52C9-sds
IG1-H52G6 Human Human IgG1 Fc (C103S) Protein, gD Tag (MALS verified)
IG1-H52G6-structure
IG1-H52G6-sds
IG1-H8213 Human Biotinylated Human IgG1 Fc protein, Avitag™ (MALS verified)
IG1-H8213-structure
IG1-H8213-sds
IG1-H5225 Human Human IgG1 Fc Protein, His Tag (MALS verified)
IG1-H5225-structure
IG1-H5225-sds
IG1-M5208 Mouse Mouse IgG1 Fc Protein, Tag Free (MALS verified)
IG1-M5208-structure
IG1-M5208-sds
FCC-H5214 Human Human IgG1 Fc Protein, Tag Free (MALS verified)
FCC-H5214-structure
FCC-H5214-sds
ACRO Quality

Part of Bioactivity data

IG1-HC2H3-Cell-based assay
 IgG1 Fc FACS

Flow cytometric analysis of HEK293/Human FcRn (FCGRT & B2M) Stable Cell staining with Human IgG1 Fc (C103S, M135Y, S137T, T139E, H316K, N317F) Protein, His Tag-Cy5 (Cat. No. IG1-HC2H3) at 1:50 dilution(2 μL of the stock solution corresponds to labeling of 2e5 cells in a final volume of 100 µL) , compared with negative control protein. Cy5 signal was used to evaluate the binding activity (QC tested).

IG1-HF2H3-Cell-based assay
 IgG1 Fc FACS

2e5 of HEK293/Human FcRn (FCGRT & B2M) Stable Cell Line (Cat. No. CHEK-ATP079) were stained with 100 μL of 10 μg/mL of FITC-Labeled Human IgG1 Fc (C103S, M135Y, S137T, T139E, H316K, N317F) Protein, His Tag (Cat. No. IG1-HF2H3) and negative control protein respectively. FITC signal was used to evaluate the binding activity (QC tested).

IG1-HC2H3-SPR
 IgG1 Fc SPR

Human IgG1 Fc Protein, His Tag-Cy5 (IG1-HC2H3) immobilized on CM4 Chip can bind Human FCGRT&B2M Heterodimer Protein, His Tag (Cat. No. FCN-H52W7) with an affinity constant of 8.27 nM as determined in a SPR assay (Biacore 8K) (QC tested).

IG1-H52H8-SPR
 IgG1 Fc SPR

Human IgG1 Fc (C103S, M135Y, S137T, T139E, H316K, N317F), His Tag (Cat. No. IG1-H52H8) immobilized on CM4 Chip can bind Human FCGRT&B2M Heterodimer Protein, His Tag (Cat. No. FCN-H52W7) with an affinity constant of 8.45 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Customer Reviews

Synonym Name

IgG1

Background

Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). IgG1 Fc was reported has a novel role as a potential anti-inflammatory drug for treatment of human autoimmune diseases.

Clinical and Translational Updates

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