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IL-1 beta

Brief Information

Name:Interleukin-1 beta
Target Synonym:IL1-BETA,IL-1,Interleukin-1beta,IL-1B,IL-1β,IL-1 β,IL1beta,Interleukin 1beta,Catabolin,IL-1 beta,IL1B,Interleukin 1 Beta,IL1F2,Pro-Interleukin-1-Beta,Preinterleukin 1 Beta,Interleukin-1 Beta
Number of Launched Drugs:6
Number of Drugs in Clinical Trials:14
Lastest Research Phase:Approved

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Part of Bioactivity data

ILB-H4110-Cell-based assay
 IL-1 beta CELL

Human IL-1 beta, premium grade (Cat. No. ILB-H4110) stimulates secretion of IFN-γ by NK-92 human natural killer lymphoma cells stimulated with 0.5 ng/mL Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag (Cat. No. IL2-H4210). The specific activity of Human IL-1 beta, premium grade is > 7.0 × 10^7 IU/mg, which is calibrated against human IL-1 beta WHO International Standard (NIBSC code: 86/680) (Routinely tested).

 IL-1 beta SPR

Human IL-1 RII, Fc Tag (Cat. No. IL2-H4256) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human IL-1 beta, His Tag (Cat. No. ILB-H51H3) with an affinity constant of 0.571 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

 IL-1 beta SPR

Human IL-1 RII, Fc Tag (Cat. No. IL2-H4256) captured on CM5 chip via anti-human IgG Fc antibodies surface can bind Human IL-1 beta, premium grade (Cat. No. ILB-H4110) with an affinity constant of 0.622 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

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Synonym Name



Interleukin-1 beta (IL-1β) is also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1 beta.IL1β are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL1α and IL1β are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1β is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Clinical and Translational Updates

Related Molecule

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Edaravone/(+)-2-Decanol SIM-071201; Y-2 Approved Jiangsu Simcere Pharmaceutical Co Ltd Mainland China Stroke Nanjing Simcere Dongyuan Pharmaceutical Co Ltd 2020-07-29 Brain Infarction; Intracranial Hemorrhages; Cerebral Hemorrhage; Stroke; Alzheimer Disease; Amyotrophic Lateral Sclerosis Details
PG-201 PG-201 Approved Viromed Layla South Korea Osteoarthritis Pmg Pharm Co Ltd 2012-01-01 Osteoarthritis, Knee; Osteoarthritis Details
Thalidomide NSC-66847; NSC-527179; K-17; VP-02 Approved Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled Mainland China Leprosy, Lepromatous Fujimoto Pharmaceutical 1982-01-01 Osteosarcoma; Leprosy, Lepromatous; Drug Resistant Epilepsy; Primary Myelofibrosis; Neuroectodermal Tumors, Primitive; Prostatitis; Colorectal Neoplasms; Lymphoma, Mantle-Cell; Sarcoma, Ewing; Retinoblastoma; Waldenstrom Macroglobulinemia; Cholangitis, Sclerosing; HIV Wasting Syndrome; Arachnoiditis; Adenocarcinoma, Clear Cell; Prostatic Neoplasms; Pancreatitis, Chronic; Lymphoma, Follicular; Sarcoma; Xerostomia; Burning Mouth Syndrome; Neoplasm Metastasis; Mycobacterium avium-intracellulare Infection; Vascular Malformations; Amyotrophic Lateral Sclerosis; Melanoma; Carcinoma, Hepatocellular; Leukemia, Lymphocytic, Chronic, B-Cell; Myelodysplastic-Myeloproliferative Diseases; Stomatitis; Erythema Nodosum; Anemia, Sideroblastic; Uterine Neoplasms; Lymphoma, Non-Hodgkin; Glioma; Angiodysplasia; Pelvic Pain; Appendiceal Neoplasms; Lung Neoplasms; Endometrial Neoplasms; Mycobacterium Infections; Gastric Antral Vascular Ectasia; Carcinoid Tumor; Lupus Erythematosus, Discoid; Stomatitis, Aphthous; Rhabdomyosarcoma; Details
Rilonacept KPL-914; RGN-303 Approved Regeneron Pharmaceuticals Inc Arcalyst United States Cryopyrin-Associated Periodic Syndromes Regeneron Pharmaceuticals Inc 2008-02-27 Pericarditis; Renal Insufficiency, Chronic; Inflammation; Gout; Scleroderma, Diffuse; Urticaria; Cryopyrin-Associated Periodic Syndromes; Hearing Loss, Sensorineural; Genetic Diseases, Inborn; Familial Mediterranean Fever; Arthritis, Juvenile; Deficiency of interleukin-1 receptor antagonist; Muckle-Wells Syndrome (MWS); Scleroderma, Systemic; Anemia; Schnitzler Syndrome; Diabetes Mellitus, Type 1; Still's Disease, Adult-Onset Details
Diacerein AC-201; AC-203; Art-50; SF-277; CCP-020; KW-4800; AC-201CR Approved Verboril, Art, 安必丁, Artrodar, Artrolyt, Cartivix, Fisiodar Epidermolysis Bullosa, Junctional; Overweight; Epidermolysis Bullosa Dystrophica; Diabetes Mellitus; Osteoarthritis, Hip; Obesity; Osteoarthritis; Arthritis; Diabetes Complications; Diabetes Mellitus, Type 2; Pemphigoid, Bullous; Osteoarthritis, Knee; Epidermolysis Bullosa; Epidermolysis Bullosa Simplex; Coronavirus Disease 2019 (COVID-19); Insulin Resistance; Non-alcoholic Fatty Liver Disease Details
Canakinumab ACZ-885 Approved Novartis Pharma Ag Ilaris United States Cryopyrin-Associated Periodic Syndromes; Muckle-Wells Syndrome (MWS) Novartis Pharma Ag 2009-06-17 Pulmonary Disease, Chronic Obstructive; Hyperimmunoglobulin D syndrome; Mucocutaneous Lymph Node Syndrome; Cryopyrin-Associated Periodic Syndromes; Arthritis, Gouty; Coronavirus Infections; Cognitive Dysfunction; Sarcoidosis, Pulmonary; Alzheimer Disease; Urticaria; Muscular Dystrophy, Duchenne; Primary Myelofibrosis; Dry Eye Syndromes; Lung Neoplasms; Gout; Carcinoma, Non-Small-Cell Lung; Macular Degeneration; Diabetes Mellitus; Behcet Syndrome; Diabetic Retinopathy; Anemia, Sickle Cell; Aortic Aneurysm, Abdominal; Peripheral Arterial Disease; Diabetes Mellitus, Type 2; Familial Mediterranean Fever; Hepatitis, Alcoholic; Prediabetic State; Diabetes Mellitus, Type 1; Atherosclerosis; Mevalonate Kinase Deficiency; Anemia; Schnitzler Syndrome; Pyoderma Gangrenosum; Polyarticular Juvenile Idiopathic Arthritis; Still's Disease, Adult-Onset; Polycythemia Vera; Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19); Myelodysplastic Syndromes; Hereditary Autoinflammatory Diseases; Vasculitis; Chronic Urticaria; Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
lutikizumab ABT-981 Phase 2 Clinical Abbvie Inc Osteoarthritis, Knee; Hidradenitis Suppurativa; Osteoarthritis Details
FL-101 FL-101 Phase 1 Clinical Flame Biosciences Inc Urinary Bladder Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Ensereptide PXL-01 Phase 3 Clinical Promore Pharma Post-surgical adhesions; Tissue Adhesions; Cicatrix Details
Efprezimod alfa CD24-Fc; HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110 Phase 3 Clinical Oncoimmune Inc Leukemia; Hematopoietic stem cell transplantation (HSCT); HIV Infections; Solid tumours; Graft vs Host Disease; Coronavirus Disease 2019 (COVID-19); Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Dyslipidemias; Leukemia, Myeloid, Acute; Melanoma Details
Ajulemic acid DMH-11C; JBT-101; CPL-7075; DMH-THC-11-OIC; CT-3; HU-239; IP-751 Phase 3 Clinical Corbus Pharma Cystic Fibrosis; Lupus Vulgaris; Dermatomyositis; Lupus Erythematosus, Systemic; Scleroderma, Diffuse Details
DLX-2323 DLX-2323 Phase 1 Clinical Delenex Therapeutics Ag Inflammation Details
Tavo-103 Tavo103; Tavo-103; TAVO-103A; TAVO103A Phase 1 Clinical Tavotek Biotherapeutics (Hong Kong) Ltd Details
Gevokizumab XMA-005.2; AB-7; XOMA-052; S-78989; VPM-087 Phase 1 Clinical Xoma Corp Colonic Neoplasms; Labyrinth Diseases; Panuveitis; Behcet Syndrome; Osteoarthritis; Uveitis; Colorectal Neoplasms; Cryopyrin-Associated Periodic Syndromes; Arthritis, Rheumatoid; Diabetes Mellitus, Type 1; Hereditary Autoinflammatory Diseases; Diabetes Mellitus, Type 2; Carcinoma, Renal Cell; Esophageal Neoplasms; Pyoderma Gangrenosum; Stomach Neoplasms; Acne Vulgaris Details
AK-114 AK-114; AK114 Phase 1 Clinical Solid tumours; Neoplasms; Inflammation; Neoplasm Metastasis Details
Recombinant humanized monoclonal antibody antiIL-1β(Cp Guojian) SSGJ-613 Phase 2 Clinical Sunshine Guojian Pharmaceutical (Shanghai) Co Ltd Tumor necrosis factor receptor associated periodic syndrome; Arthritis, Juvenile; Arthritis, Gouty; Gout; Inflammation Details
Goflikicept RPH-104 Phase 3 Clinical Trpharm Still's Disease, Adult-Onset; Familial Mediterranean Fever; ST Elevation Myocardial Infarction; Schnitzler Syndrome; Coronavirus Disease 2019 (COVID-19); Pericarditis; Gout Details
CU-06 CU-06-EYE; CU-06-IBD; CU-061004; Sac-1004; CU-06-ONCO; CU-06-HAE; CU06-1004 Phase 2 Clinical Curacle Co Ltd Myocardial Infarction; Neoplasms; Lung Diseases; Stroke; Diabetic macular oedema; Colitis, Ulcerative; Macular Degeneration; Angioedemas, Hereditary; Crohn Disease; Diabetic Retinopathy Details
Kinnazumab Phase 3 Clinical Changchun Genescience Pharmaceutical Co Ltd Solid tumours; Still's Disease, Adult-Onset; Arthritis, Juvenile; Arthritis, Gouty; Gout Details

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