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IL-1 beta

Brief Information

Name:Interleukin-1 beta
Target Synonym:Interleukin 1beta,IL1beta,Catabolin,IL-1 beta,IL1B,Interleukin 1 Beta,IL1F2,Pro-Interleukin-1-Beta,Preinterleukin 1 Beta,Interleukin-1 Beta,IL1-BETA,IL-1,Interleukin-1beta,IL-1B
Number of Launched Drugs:4
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Approved

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Part of Bioactivity data

ILB-H4110-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Human IL-1 beta, Tag Free (Cat. No. ILB-H4110) stimulates secretion of IFN-gamma by NK-92 human natural killer lymphoma cells. The EC50 for this effect is 1.02-1.33 ng/mL (Routinely tested).

ILB-H4110-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IL-1 RII, Fc Tag (Cat. No. IL2-H4256) captured on CM5 chip via anti-human IgG Fc antibodies surface can bind Human IL-1 beta, Tag Free (Cat. No. ILB-H4110) with an affinity constant of 0.622 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

ILB-M51H3-ELISA
Mouse IL-1 beta, His TagMouse IL-1 beta, His Tag (Cat. No. ILB-M51H3) ELISA bioactivity

Immobilized Mouse IL-1 beta, His Tag (Cat. No. ILB-M51H3) at 10 μg/mL (100 μL/well) can bind Human IL-1 RII, Fc Tag (Cat. No. IL2-H4256) with a linear range of 20-156 ng/mL (QC tested).

Synonym Name

IL1B,IL-1BETA,IL1F2,IL-1β

Background

Interleukin-1 beta (IL-1β) is also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1 beta.IL1β are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL1α and IL1β are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1β is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Clinical and Translational Updates

Related Molecule

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
PG-201 PG-201 Approved Viromed Layla South Korea Osteoarthritis Pmg Pharm Co Ltd 2012-01-01 Osteoarthritis, Knee; Osteoarthritis Details
Diacerein AC-201; AC-203; Art-50; SF-277; CCP-020; KW-4800; AC-201CR Approved Verboril, Art, 安必丁, Artrodar, Artrolyt, Cartivix, Fisiodar Diabetes Mellitus, Type 2; Epidermolysis Bullosa Simplex; Epidermolysis Bullosa; Epidermolysis Bullosa, Junctional; Osteoarthritis, Knee; Diabetes Complications; Pemphigoid, Bullous; Arthritis; Osteoarthritis; Osteoarthritis, Hip; Diabetes Mellitus; Epidermolysis Bullosa Dystrophica Details
Rilonacept KPL-914; RGN-303 Approved Regeneron Pharmaceuticals Inc Arcalyst United States Pericarditis Regeneron Pharmaceuticals Inc 2008-02-27 Anemia; Muckle-Wells Syndrome (MWS); Genetic Diseases, Inborn; Arthritis, Juvenile; Hyperlipoproteinemia Type I; Pericarditis; Cryopyrin-Associated Periodic Syndromes; Gout; Renal Insufficiency, Chronic Details
Canakinumab ACZ-885 Approved Novartis Pharma Ag Ilaris United States Still's Disease, Adult-Onset Novartis Pharma Ag 2009-06-17 Aortic Aneurysm, Abdominal; Cryopyrin-Associated Periodic Syndromes; Arthritis, Gouty; Colorectal Neoplasms; Osteoarthritis, Knee; Sarcoidosis, Pulmonary; Cognitive Dysfunction; Alzheimer Disease; Gout; Pulmonary Disease, Chronic Obstructive; Tumor necrosis factor receptor associated periodic syndrome; Melanoma; Peripheral Arterial Disease; Anemia, Sickle Cell; Diabetes Mellitus; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Behcet Syndrome; Macular Degeneration; Hereditary Autoinflammatory Diseases; Familial Mediterranean Fever; Prediabetic State; Cytokine Release Syndrome; Still's Disease, Adult-Onset; Atherosclerosis; Mevalonate Kinase Deficiency; Diabetes Mellitus, Type 2; Triple Negative Breast Neoplasms; Diabetes Mellitus, Type 1; Coronavirus Disease 2019 (COVID-19); Myelodysplastic Syndromes; Muckle-Wells Syndrome (MWS); Arthritis, Rheumatoid; Dry Eye Syndromes; Arthritis, Juvenile; Mucocutaneous Lymph Node Syndrome; Hyperimmunoglobulin D syndrome Details
Thalidomide NSC-66847; NSC-527179; K-17; VP-02 Approved Celgene Corp Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled Japan Leprosy, Lepromatous Fujimoto Pharmaceutical 1982-01-01 HIV Infections; Spondylitis, Ankylosing; Myelodysplastic Syndromes; Idiopathic Pulmonary Fibrosis; Multiple Myeloma; HIV Wasting Syndrome; Erythema Nodosum; Leprosy, Lepromatous; Carcinoma, Hepatocellular Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
PXL-01 PXL-01 Phase 3 Clinical Promore Pharma Tissue Adhesions; Post-surgical adhesions Details
HMPL-004 (Hutchison Medipharma) HMPL-004 Phase 3 Clinical Hutchison Medipharma Ltd Lupus Erythematosus, Systemic; Colitis, Ulcerative; Crohn Disease Details
Ajulemic acid CT-3; HU-239; IP-751; DMH-11C; JBT-101; CPL-7075; DMH-THC-11-OIC Phase 3 Clinical Corbus Pharma Cystic Fibrosis; Dermatomyositis; Scleroderma, Systemic; Lupus Erythematosus, Systemic; Scleroderma, Diffuse Details
RPH-104 RPH-104 Phase 3 Clinical Trpharm Schnitzler Syndrome; ST Elevation Myocardial Infarction; Coronavirus Disease 2019 (COVID-19); Gout Details
Gevokizumab AB-7; S-78989; VPM-087; XOMA-052; XMA-005.2 Phase 3 Clinical Xoma Acne Vulgaris; Diabetes Mellitus, Type 1; Pyoderma Gangrenosum; Diabetes Mellitus, Type 2; Carcinoma, Renal Cell; Esophageal Neoplasms; Stomach Neoplasms; Arthritis, Rheumatoid; Colorectal Neoplasms; Uveitis; Osteoarthritis; Behcet Syndrome; Labyrinth Diseases; Panuveitis Details
ALTA-2530 OSP-101; ALTA-2530 Clinical Details
金纳单抗 Phase 1 Clinical Changchun Genescience Pharmaceutical Co Ltd Arthritis, Juvenile; Arthritis, Gouty; Gout Details
CD24-Fc MK-7110; MK7110; HAS-CD24; CD24-Fc-IgG; CD24-Fc Phase 3 Clinical Oncoimmune HIV Infections; Hematopoietic stem cell transplantation (HSCT); Leukemia; Graft vs Host Disease; Coronavirus Disease 2019 (COVID-19); Myelodysplastic Syndromes; Dyslipidemias; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute; Melanoma Details
FL-101 FL-101 Phase 2 Clinical Flame Biosciences Inc Carcinoma, Non-Small-Cell Lung Details
Recombinant humanized monoclonal antibody antiIL-1β SSGJ-613 Phase 1 Clinical Shanghai Cp Guojian Pharmaceutical Co Ltd Tumor necrosis factor receptor associated periodic syndrome; Arthritis, Juvenile Details

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