Acrobiosystems for English
icon_bulk_orderBulk inquiry/Quick order
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > IL-1 beta

IL-1 beta

Brief Information

Name:Interleukin-1 beta
Target Synonym:IL1-BETA,IL-1,Interleukin-1beta,IL-1B,IL-1β,IL-1 β,IL1beta,Interleukin 1beta,Catabolin,IL-1 beta,IL1B,Interleukin 1 Beta,IL1F2,Pro-Interleukin-1-Beta,Preinterleukin 1 Beta,Interleukin-1 Beta
Number of Launched Drugs:7
Number of Drugs in Clinical Trials:17
Lastest Research Phase:Approved

Product ListCompare or Buy

ACRO Quality

Part of Bioactivity data

 IL-1 beta SPR

Human IL-1 RII, Fc Tag (Cat. No. IL2-H4256) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human IL-1 beta, His Tag (Cat. No. ILB-H51H3) with an affinity constant of 0.571 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

 IL-1 beta ELISA

Immobilized Human IL-1 beta, His Tag (Cat. No. ILB-H51H3) at 10 μg/mL (100 μL/well) can bind Human IL-1 RII, Fc Tag (Cat. No. IL2-H4256) with a linear range of 2-13 ng/mL (QC tested).

Customer Reviews

Synonym Name



Interleukin-1 beta (IL-1β) is also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1 beta.IL1β are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL1α and IL1β are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1β is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Clinical and Translational Updates

Related Molecule

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Canakinumab ACZ-885 Approved Novartis Pharma Ag Ilaris United States Cryopyrin-Associated Periodic Syndromes; Muckle-Wells Syndrome (MWS) Novartis Pharma Ag 2009-06-17 Gout; Hyperimmunoglobulin D syndrome; Mucocutaneous Lymph Node Syndrome; Cryopyrin-Associated Periodic Syndromes; Arthritis, Gouty; Cognitive Dysfunction; Sarcoidosis, Pulmonary; Alzheimer Disease; Urticaria; Muscular Dystrophy, Duchenne; Primary Myelofibrosis; Pulmonary Disease, Chronic Obstructive; Dry Eye Syndromes; Lung Neoplasms; Macular Degeneration; Carcinoma, Non-Small-Cell Lung; Anemia, Sickle Cell; Diabetes Mellitus; Behcet Syndrome; Aortic Aneurysm, Abdominal; Peripheral Arterial Disease; Diabetic Retinopathy; Thrombocythemia, Essential; Polycythemia Vera; Familial Mediterranean Fever; Prediabetic State; Diabetes Mellitus, Type 1; Hepatitis, Alcoholic; Schnitzler Syndrome; Atherosclerosis; Mevalonate Kinase Deficiency; Pyoderma Gangrenosum; Polyarticular Juvenile Idiopathic Arthritis; Diabetes Mellitus, Type 2; Anemia; Still's Disease, Adult-Onset; Arthritis, Rheumatoid; Small Cell Lung Carcinoma; Coronavirus Disease 2019 (COVID-19); Hereditary Autoinflammatory Diseases; Chronic Urticaria; Vasculit Details
PG-201 PG-201 Approved Viromed Layla South Korea Osteoarthritis Pmg Pharm Co Ltd 2012-01-01 Osteoarthritis, Knee; Osteoarthritis Details
Edaravone/(+)-2-Decanol SIM-071201; Y-2 Approved Jiangsu Simcere Pharmaceutical Co Ltd Sanbexin, 三贝心, 三贝欣 Mainland China Stroke Nanjing Simcere Dongyuan Pharmaceutical Co Ltd 2020-07-29 Intracranial Hemorrhages; Brain Infarction; Cerebral Hemorrhage; Stroke; Alzheimer Disease; Cognitive Dysfunction; Amyotrophic Lateral Sclerosis; Cognition Disorders Details
Diacerein KW-4800; SF-277; Art-50 Approved Cartivix, Fisiodar, Verboril, Art, 安必丁, Artrodar, Artrolyt Metabolic Dysfunction-Associated Steatotic Liver Disease; Diabetes Mellitus, Type 2; Insulin Resistance; Coronavirus Disease 2019 (COVID-19); Epidermolysis Bullosa; Osteoarthritis, Knee; Diabetes Complications; Osteoarthritis; Obesity; Osteoarthritis, Hip; Diabetes Mellitus; Overweight Details
Andrographolide/Sodium Hydrogen Sulfite Approved Bacterial Infections Details
Rilonacept RGN-303; KPL-914 Approved Regeneron Pharmaceuticals Inc Arcalyst United States Cryopyrin-Associated Periodic Syndromes Kiniksa Pharmaceuticals Ltd 2008-02-27 Pericarditis; Inflammation; Scleroderma, Diffuse; Renal Insufficiency, Chronic; Gout; Urticaria; Cryopyrin-Associated Periodic Syndromes; Hearing Loss, Sensorineural; Genetic Diseases, Inborn; Diabetes Mellitus, Type 1; Arthritis, Juvenile; Deficiency of interleukin-1 receptor antagonist; Scleroderma, Systemic; Muckle-Wells Syndrome (MWS); Anemia; Schnitzler Syndrome; Familial Mediterranean Fever; Still's Disease, Adult-Onset Details
Thalidomide NSC-66847; NSC-527179; K-17; VP-02; FPF-300; FPF300 Approved Celgene Corp Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled Mainland China Leprosy, Lepromatous; Multiple Myeloma Changzhou Pharmaceutical Factory 1982-01-01 HIV Wasting Syndrome; Angiodysplasia; Primary Myelofibrosis; Neuroectodermal Tumors, Primitive; Prostatitis; Colorectal Neoplasms; Osteosarcoma; Lymphoma, Mantle-Cell; Sarcoma, Ewing; Retinoblastoma; Erythema Nodosum; Drug Resistant Epilepsy; Xerostomia; Sarcoma; Pancreatitis, Chronic; Adenocarcinoma, Clear Cell; Lymphoma, Follicular; Arachnoiditis; Carcinoma, Adenosquamous; Gastrointestinal Hemorrhage; Cholangitis, Sclerosing; Prostatic Neoplasms; Pelvic Pain; Neoplasm Metastasis; Stomatitis; Burning Mouth Syndrome; Mycobacterium avium-intracellulare Infection; Amyotrophic Lateral Sclerosis; Melanoma; Myelodysplastic-Myeloproliferative Diseases; Carcinoma, Hepatocellular; Leukemia, Lymphocytic, Chronic, B-Cell; Vascular Malformations; Tuberculosis; Appendiceal Neoplasms; Lymphoma, Non-Hodgkin; Uterine Neoplasms; Anemia, Sideroblastic; Glioma; Leprosy, Lepromatous; Endometrial Neoplasms; Lung Neoplasms; Waldenstrom Macroglobulinemia; Kidney Neoplasms; Thalassemia; Carcinoid Tumor; Lupus Erythematosus, Discoid Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Ensereptide PXL-01 Phase 3 Clinical Promore Pharma Post-surgical adhesions; Tissue Adhesions; Cicatrix Details
Efprezimod alfa CD24-Fc; HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110 Phase 3 Clinical Oncoimmune Inc Solid tumours; Hematopoietic stem cell transplantation (HSCT); Leukemia; HIV Infections; Graft vs Host Disease; Myelodysplastic Syndromes; Coronavirus Disease 2019 (COVID-19); Precursor Cell Lymphoblastic Leukemia-Lymphoma; Dyslipidemias; Leukemia, Myeloid, Acute; Melanoma Details
Goflikicept RPH-104 Phase 3 Clinical Trpharm Still's Disease, Adult-Onset; Familial Mediterranean Fever; Myocardial Infarction; Schnitzler Syndrome; ST Elevation Myocardial Infarction; Coronavirus Disease 2019 (COVID-19); Pericarditis; Gout Details
Recombinant humanized monoclonal antibody antiIL-1β(Cp Guojian) SSGJ-613 Phase 3 Clinical Sunshine GuoJian Pharmaceutical (Shanghai) Co Ltd Tumor necrosis factor receptor associated periodic syndrome; Arthritis, Juvenile; Arthritis, Gouty; Gout; Inflammation Details
MAS-825 MAS-825; MAS825 Phase 3 Clinical Novartis Pharmaceuticals Corp Enterocolitis; Coronavirus Disease 2019 (COVID-19); Coronary Disease; Autoimmune Lymphoproliferative Syndrome Details
lutikizumab ABT-981 Phase 2 Clinical Abbvie Inc Osteoarthritis, Knee; Colitis, Ulcerative; Hidradenitis Suppurativa; Osteoarthritis Details
CU-06 CU-06-EYE; CU-06-IBD; CU-061004; Sac-1004; CU-06-ONCO; CU-06-HAE; CU06-1004 Phase 2 Clinical Curacle Co Ltd Myocardial Infarction; Neoplasms; Lung Diseases; Stroke; Diabetic macular oedema; Colitis, Ulcerative; Diabetic Retinopathy; Crohn Disease; Macular Degeneration; Angioedemas, Hereditary Details
IL1-beta receptor antagonist Therapy(Hamlet BioPharma) Phase 2 Clinical Hamlet BioPharma AB Cystitis; Pain Details
Diacerein (TWi Biotechnology/Castle Creek Pharmaceuticals) AC-201; AC-201 Controlled release tablet; AC-201 CR; AC-203; CCP 020; CCP-020 Phase 2 Clinical Twi Biotechnology Inc Diabetes Mellitus, Type 2; Epidermolysis Bullosa; Epidermolysis Bullosa Simplex; Pemphigoid, Bullous; Epidermolysis Bullosa, Junctional; Arthritis; Gout; Epidermolysis Bullosa Dystrophica Details
Gevokizumab XMA-005.2; AB-7; XOMA-052; S-78989; VPM-087; XMA-0052 Phase 1 Clinical Xoma Corp Colonic Neoplasms; Behcet Syndrome; Panuveitis; Labyrinth Diseases; Osteoarthritis; Uveitis; Colorectal Neoplasms; Cryopyrin-Associated Periodic Syndromes; Hereditary Autoinflammatory Diseases; Diabetes Mellitus, Type 1; Arthritis, Rheumatoid; Pyoderma Gangrenosum; Stomach Neoplasms; Carcinoma, Renal Cell; Esophageal Neoplasms; Diabetes Mellitus, Type 2; Acne Vulgaris Details
DLX-2323 DLX-2323 Phase 1 Clinical Delenex Therapeutics Ag Inflammation Details
Tavo-103 Tavo103; Tavo-103; TAVO-103A; TAVO103A Phase 1 Clinical Tavotek Biotherapeutics (Hong Kong) Ltd Details
FL-101 FL-101 Phase 1 Clinical Flame Biosciences Inc Urinary Bladder Neoplasms; Carcinoma, Non-Small-Cell Lung Details
AK-114 AK-114; AK114 Phase 1 Clinical Zhongshan Akeso Biopharma Co Ltd Solid tumours; Neoplasms; Inflammation; Neoplasm Metastasis Details

This web search service is supported by Google Inc.

Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
+1 888-377-6111
1 Innovation Way, Newark, DE 19711, USA

Leave a message