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IL-1 beta

IL-1 beta Molecule Information

Name:Interleukin-1 beta
Target Synonym:Catabolin;Interleukin-1 beta;IL1B;IL1F2;IL-1 beta
Number of Launched Drugs:5
Number of Drugs in Clinical Trials:20
Lastest Research Phase:Approved

IL-1 beta Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
ILB-H4110 Human Human IL-1 beta / IL-1F2 Protein, Tag Free, low endotoxin
ILB-H4110-structure
ILB-H4110-sds
ILB-H4110-elisa_1

IL-1 beta Molecule Synonym Name

IL1B,IL-1BETA,IL1F2,IL-1¦Â

IL-1 beta Molecule Background

Interleukin-1 beta (IL-1¦Â) is also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1¦Â precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1 beta. IL1¦Â are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL1¦Á and IL1¦Â are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1¦Â is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

IL-1 beta References

IL-1 beta Related Molecule

IL-1 beta Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Canakinumab ACZ-885,ACZ885 Approved Novartis ILARIS fda Tumor necrosis factor receptor associated periodic syndrome, Cryopyrin-Associated Periodic Syndromes (CAPS), Systemic juvenile idiopathic arthritis, Hyperimmunoglobulin D syndrome, Familial mediterranean fever NOVARTIS PHARMS 2009-06-17 Juvenile idiopathic arthritis (JIA), Tumor necrosis factor receptor associated periodic syndrome, Cryopyrin-Associated Periodic Syndromes (CAPS), Systemic juvenile idiopathic arthritis, Hyperimmunoglobulin D syndrome, Arthritis, Familial mediterranean fever Details
Rilonacept KPL-914; RGN-303 Approved Regeneron Pharmaceutical, kiniksa pharmaceuticals ARCALYST fda Muckle-Wells Syndrome (MWS), Familial chylomicronemia syndrome (FCS), Cryopyrin-Associated Periodic Syndromes (CAPS) REGENERON PHARMACEUTICALS 2008-02-27 Cardiovascular disorders, Familial chylomicronemia syndrome (FCS), Muckle-Wells Syndrome (MWS), Urticaria, Cryopyrin-Associated Periodic Syndromes (CAPS) Details
PG-201 PG-201,PG 201 Approved ViroMed, PMG Pharm Osteoarthritis (OA) Details
Diacerein AC-201; AC-203; KW-4800; SF-277; AC-201CR; CCP-020; Art-50 Approved Unknown Diacerein Capsules cfda Osteoarthritis (OA) 2015-03-15 Osteoarthritis (OA) Details
Thalidomide NSC-527179; NSC-66847; K-17,NSC527179; NSC66847; K17,NSC 527179; NSC 66847; K 17 Approved Celgene THALOMID fda Erythema nodosum leprosum (ENL), Multiple myeloma (MM) CELGENE 1998-07-16 Erythema nodosum leprosum (ENL), Multiple myeloma (MM) Details

IL-1 beta Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Aceclofenac/Diacerein/Glucosamine Phase Ⅲ Jenburkt Pharmaceuticals Osteoarthritis (OA) Details
Interleukin-1 receptor (Immunex) Phase Ⅱ Amgen Myeloid leukemia, Type 1 diabetes, HIV infection, Graft versus host disease, Transplant rejection, Hypersensitivity Details
HMPL-004 (Hutchison Medipharma) HMPL-004 Phase Ⅲ Hutchison Medipharma Ulcerative colitis, Crohn's disease Details
MRX-1 MRX-1,MRX 1,MRX1 Phase Ⅰ Akari Atopic dermatitis Details
CYT 013 IL1bQb Phase Ⅱ Kuros Biosciences Type 2 diabetes Details
Aceclofenac/Diacerein Phase Not Specified Cadila Healthcare Osteoarthritis (OA) Details
IL-1 Affibody Preclinical Affibody, SOBI Autoimmune diseases, Inflammation Details
APX-002 (Apexigen/Jiangsu T-mab BioPharma) APX-002; TK-002 Preclinical Epitomics, Apexigen, Jiangsu T-mab BioPharma Inflammation Details
Binetrakin Sch-39400 Phase Ⅱ Merck Sharp & Dohme, Nonindustrial source Non small cell lung cancer (NSCLC), Gastrointestinal cancer, Solid tumours, Inflammation, Acute lymphoblastic leukaemia (ALL), Rheumatoid arthritis (RA), Immunodeficiency disorders Details
CC-11006 CC-11006 Phase Ⅰ Celgene Myelodysplastic syndrome (MDS), Inflammation Details
Ajulemic acid CPL-7075; CT-3; DMH-THC-11-OIC; DMH-11C; HU-239; IP-751; JBT-101 Phase Ⅲ Corbus Pharma Cystic fibrosis (CF), Systemic lupus erythematosus, Dermatomyositis, Systemic sclerosis Details
lutikizumab ABT-981 Phase Ⅱ Abbvie Osteoarthritis (OA) Details
CDP-484 CDP-484 Phase Ⅱ UCB, Nektar Rheumatoid arthritis (RA) Details
RPH-104 RPH-104 Phase Ⅰ TRPHARM Inflammation Details
KOB-03 KOB-03 Phase Ⅱ Dong Wha Pharmaceuticals Allergic rhinitis (AR) Details
金纳单抗 Phase Ⅰ GeneScience Pharmaceutical (GenSci) Acute gouty arthritis (GA), Systemic juvenile idiopathic arthritis Details
Gevokizumab AB-7; S-78989; XMA-005.2; XOMA-052; VPM-087 Phase Ⅲ Xoma, Novartis Uveitis Details
LY 2189102 LY-2189102 Phase Ⅱ Lilly Cardiovascular disorders, Type 2 diabetes, Rheumatoid arthritis (RA) Details
Mobenakin OCT-43 BLA Filing Nonindustrial source, Otsuka, Chiron Urogenital cancer, Glioma, Lymphoma, Cancer Details
PXL-01 PXL-01 Phase Ⅲ ProMore Pharma, Technomark Life Sciences, PharmaResearch Products Post-surgical adhesions Details

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