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Your Position: Home > IL-1 beta

IL-1 beta

Brief Information

Name:Interleukin-1 beta
Target Synonym:IL1-BETA,IL-1,Interleukin-1beta,IL-1B,IL-1β,IL-1 β,IL1beta,Interleukin 1beta,Catabolin,IL-1 beta,IL1B,Interleukin 1 Beta,IL1F2,Pro-Interleukin-1-Beta,Preinterleukin 1 Beta,Interleukin-1 Beta
Number of Launched Drugs:5
Number of Drugs in Clinical Trials:10
Lastest Research Phase:Approved

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Part of Bioactivity data

ILB-H4110-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Human IL-1 beta, Tag Free (Cat. No. ILB-H4110) stimulates secretion of IFN-gamma by NK-92 human natural killer lymphoma cells. The EC50 for this effect is 1.02-1.33 ng/mL (Routinely tested).

ILB-H51H3-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IL-1 RII, Fc Tag (Cat. No. IL2-H4256) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human IL-1 beta, His Tag (Cat. No. ILB-H51H3) with an affinity constant of 0.571 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

ILB-H4110-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IL-1 RII, Fc Tag (Cat. No. IL2-H4256) captured on CM5 chip via anti-human IgG Fc antibodies surface can bind Human IL-1 beta, Tag Free (Cat. No. ILB-H4110) with an affinity constant of 0.622 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Synonym Name

IL1B,IL-1BETA,IL1F2,IL-1β

Background

Interleukin-1 beta (IL-1β) is also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1 beta.IL1β are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL1α and IL1β are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1β is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Clinical and Translational Updates

Related Molecule

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Rilonacept KPL-914; RGN-303 Approved Regeneron Pharmaceuticals Inc Arcalyst United States Pericarditis Regeneron Pharmaceuticals Inc 2008-02-27 Anemia; Muckle-Wells Syndrome (MWS); Genetic Diseases, Inborn; Arthritis, Juvenile; Hyperlipoproteinemia Type I; Pericarditis; Cryopyrin-Associated Periodic Syndromes; Gout; Renal Insufficiency, Chronic Details
Diacerein AC-201; AC-203; Art-50; SF-277; CCP-020; KW-4800; AC-201CR Approved Verboril, Art, 安必丁, Artrodar, Artrolyt, Cartivix, Fisiodar Diabetes Mellitus, Type 2; Epidermolysis Bullosa Simplex; Epidermolysis Bullosa; Epidermolysis Bullosa, Junctional; Osteoarthritis, Knee; Diabetes Complications; Pemphigoid, Bullous; Osteoarthritis; Arthritis; Osteoarthritis, Hip; Diabetes Mellitus; Epidermolysis Bullosa Dystrophica Details
PG-201 PG-201 Approved Viromed Layla South Korea Osteoarthritis Pmg Pharm Co Ltd 2012-01-01 Osteoarthritis, Knee; Osteoarthritis Details
Thalidomide NSC-66847; NSC-527179; K-17; VP-02 Approved Celgene Corp Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled Japan Leprosy, Lepromatous Fujimoto Pharmaceutical 1982-01-01 HIV Infections; Spondylitis, Ankylosing; Myelodysplastic Syndromes; Idiopathic Pulmonary Fibrosis; Multiple Myeloma; HIV Wasting Syndrome; Erythema Nodosum; Leprosy, Lepromatous; Carcinoma, Hepatocellular Details
Canakinumab ACZ-885 Approved Novartis Pharma Ag Ilaris United States Still's Disease, Adult-Onset Novartis Pharma Ag 2009-06-17 Carcinoma, Non-Small-Cell Lung; Arthritis, Gouty; Sarcoidosis, Pulmonary; Colorectal Neoplasms; Osteoarthritis, Knee; Cognitive Dysfunction; Alzheimer Disease; Gout; Pulmonary Disease, Chronic Obstructive; Cryopyrin-Associated Periodic Syndromes; Diabetes Mellitus; Aortic Aneurysm, Abdominal; Anemia, Sickle Cell; Peripheral Arterial Disease; Adenocarcinoma; Macular Degeneration; Behcet Syndrome; Melanoma; Muckle-Wells Syndrome (MWS); Diabetes Mellitus, Type 1; Still's Disease, Adult-Onset; Prediabetic State; Atherosclerosis; Diabetes Mellitus, Type 2; Mevalonate Kinase Deficiency; Triple Negative Breast Neoplasms; Hereditary Autoinflammatory Diseases; Familial Mediterranean Fever; Arthritis, Rheumatoid; Myelodysplastic Syndromes; Arthritis, Juvenile; Mucocutaneous Lymph Node Syndrome; Tumor necrosis factor receptor associated periodic syndrome; Hyperimmunoglobulin D syndrome; Dry Eye Syndromes Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Ensereptide PXL-01 Phase 3 Clinical Promore Pharma Tissue Adhesions; Post-surgical adhesions; Cicatrix Details
Recombinant humanized monoclonal antibody antiIL-1β SSGJ-613 Phase 1 Clinical Shanghai Cp Guojian Pharmaceutical Co Ltd Tumor necrosis factor receptor associated periodic syndrome; Arthritis, Juvenile; Inflammation Details
Ajulemic acid CT-3; HU-239; IP-751; DMH-11C; JBT-101; CPL-7075; DMH-THC-11-OIC Phase 3 Clinical Corbus Pharma Cystic Fibrosis; Dermatomyositis; Scleroderma, Systemic; Lupus Erythematosus, Systemic; Scleroderma, Diffuse Details
ALTA-2530 OSP-101; ALTA-2530 Clinical Details
Gevokizumab(Xoma) XMA-005.2; AB-7; XOMA-052; S-78989; VPM-087 Phase 3 Clinical Xoma Diabetes Mellitus, Type 1; Acne Vulgaris; Pyoderma Gangrenosum; Diabetes Mellitus, Type 2; Carcinoma, Renal Cell; Stomach Neoplasms; Esophageal Neoplasms; Arthritis, Rheumatoid; Colorectal Neoplasms; Uveitis; Osteoarthritis; Labyrinth Diseases; Panuveitis; Behcet Syndrome Details
Kinnazumab Phase 2 Clinical Changchun Genescience Pharmaceutical Co Ltd Solid tumours; Arthritis, Juvenile; Arthritis, Gouty; Gout Details
lutikizumab ABT-981 Phase 2 Clinical Abbvie Inc Osteoarthritis, Knee; Osteoarthritis; Hidradenitis Suppurativa Details
DLX-2323 DLX-2323 Phase 1 Clinical Delenex Therapeutics Inflammation Details
Efprezimod alfa CD24-Fc; HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110 Phase 3 Clinical Oncoimmune Leukemia; Hematopoietic stem cell transplantation (HSCT); HIV Infections; Graft vs Host Disease; Coronavirus Disease 2019 (COVID-19); Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Dyslipidemias; Leukemia, Myeloid, Acute; Melanoma Details
RPH-104 RPH-104 Phase 3 Clinical Trpharm Familial Mediterranean Fever; Schnitzler Syndrome; ST Elevation Myocardial Infarction; Coronavirus Disease 2019 (COVID-19); Pericarditis; Gout Details
AK-114 AK-114; AK114 Phase 1 Clinical Zhongshan Akeso Biopharma Co Ltd Solid tumours; Inflammation; Neoplasm Metastasis Details

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