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Your Position: Home > IL-1 beta

IL-1 beta

Brief Information

Name:Interleukin-1 beta
Target Synonym:IL1-BETA,IL-1,Interleukin-1beta,IL-1B,IL-1β,IL-1 β,IL1beta,Interleukin 1beta,Catabolin,IL-1 beta,IL1B,Interleukin 1 Beta,IL1F2,Pro-Interleukin-1-Beta,Preinterleukin 1 Beta,Interleukin-1 Beta
Number of Launched Drugs:5
Number of Drugs in Clinical Trials:10
Lastest Research Phase:Approved

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Part of Bioactivity data

ILB-H4110-Cell-based assay
 IL-1 beta CELL

Human IL-1 beta, premium grade (Cat. No. ILB-H4110) stimulates secretion of IFN-gamma by NK-92 human natural killer lymphoma cells. The EC50 for this effect is 1.02-1.33 ng/mL (Routinely tested).

ILB-H51H3-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IL-1 RII, Fc Tag (Cat. No. IL2-H4256) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human IL-1 beta, His Tag (Cat. No. ILB-H51H3) with an affinity constant of 0.571 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

ILB-H4110-SPR
 IL-1 beta SPR

Human IL-1 RII, Fc Tag (Cat. No. IL2-H4256) captured on CM5 chip via anti-human IgG Fc antibodies surface can bind Human IL-1 beta, premium grade (Cat. No. ILB-H4110) with an affinity constant of 0.622 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Synonym Name

IL1B,IL-1BETA,IL1F2,IL-1β

Background

Interleukin-1 beta (IL-1β) is also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1 beta.IL1β are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL1α and IL1β are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1β is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Clinical and Translational Updates

Related Molecule

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Rilonacept KPL-914; RGN-303 Approved Regeneron Pharmaceuticals Inc Arcalyst United States Pericarditis Regeneron Pharmaceuticals Inc 2008-02-27 Pericarditis; Cryopyrin-Associated Periodic Syndromes Details
PG-201 PG-201 Approved Viromed Layla South Korea Osteoarthritis Pmg Pharm Co Ltd 2012-01-01 Osteoarthritis Details
Thalidomide NSC-66847; NSC-527179; K-17; VP-02 Approved Celgene Corp Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled Japan Leprosy, Lepromatous Fujimoto Pharmaceutical 1982-01-01 Waldenstrom Macroglobulinemia; Sarcoma; Prostatic Neoplasms; Arachnoiditis; Cholangitis, Sclerosing; Gastrointestinal Hemorrhage; Osteosarcoma; Pancreatitis, Chronic; Retinoblastoma; Sarcoma, Ewing; Lymphoma, Mantle-Cell; Prostatitis; Colitis, Ulcerative; Colorectal Neoplasms; Neuroectodermal Tumors, Primitive; Erythema Nodosum; Leprosy, Lepromatous; Endometrial Neoplasms; Appendiceal Neoplasms; Pelvic Pain; Angiodysplasia; Glioma; Lymphoma, Non-Hodgkin; Carcinoma, Hepatocellular; Amyotrophic Lateral Sclerosis; Vascular Malformations; Crohn Disease; Precancerous Conditions; Mycobacterium avium-intracellulare Infection; Idiopathic Pulmonary Fibrosis; Leukemia; Lymphoma, B-Cell, Marginal Zone; Lymphoma, B-Cell; Liver Neoplasms; Cough; Telangiectasia, Hereditary Hemorrhagic; Mycobacterium Infections; Rhabdomyosarcoma; Arteriovenous Malformations; Inflammatory Bowel Diseases; Stomatitis, Aphthous; Gastric Antral Vascular Ectasia; Spondylitis, Ankylosing; Myelodysplastic Syndromes; HIV Infections; Coronavirus Dise Details
Canakinumab ACZ-885 Approved Novartis Pharma Ag Ilaris United States Still's Disease, Adult-Onset Novartis Pharma Ag 2009-06-17 Gout; Cryopyrin-Associated Periodic Syndromes; Arthritis, Gouty; Coronavirus Infections; Atrial Fibrillation; Cognitive Dysfunction; Sarcoidosis, Pulmonary; Alzheimer Disease; Osteoarthritis, Knee; Colorectal Neoplasms; Urticaria; Primary Myelofibrosis; Pulmonary Disease, Chronic Obstructive; Hyperimmunoglobulin D syndrome; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung; Macular Degeneration; Adenocarcinoma; Diabetes Mellitus; Behcet Syndrome; Diabetic Retinopathy; Anemia, Sickle Cell; Aortic Aneurysm, Abdominal; Melanoma; Peripheral Arterial Disease; Myelodysplastic Syndromes; Familial Mediterranean Fever; Hepatitis, Alcoholic; Prediabetic State; Diabetes Mellitus, Type 1; Atherosclerosis; Mevalonate Kinase Deficiency; Anemia; Schnitzler Syndrome; Pyoderma Gangrenosum; Diabetes Mellitus, Type 2; Carcinoma, Renal Cell; Arthritis, Rheumatoid; Still's Disease, Adult-Onset; Triple Negative Breast Neoplasms; Hereditary Autoinflammatory Diseases; Vasculitis; Coronavirus Disease 2019 (COVID-19); Chron Details
Diacerein AC-201; AC-203; Art-50; SF-277; CCP-020; KW-4800; AC-201CR Approved Verboril, Art, 安必丁, Artrodar, Artrolyt, Cartivix, Fisiodar Diabetes Mellitus, Type 2; Non-alcoholic Fatty Liver Disease; Insulin Resistance; Coronavirus Disease 2019 (COVID-19); Epidermolysis Bullosa Simplex; Epidermolysis Bullosa; Osteoarthritis, Knee; Pemphigoid, Bullous; Epidermolysis Bullosa, Junctional; Diabetes Complications; Arthritis; Osteoarthritis; Osteoarthritis, Hip; Diabetes Mellitus; Epidermolysis Bullosa Dystrophica Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
DLX-2323 DLX-2323 Phase 1 Clinical Delenex Therapeutics Inflammation Details
Kinnazumab Phase 2 Clinical Changchun Genescience Pharmaceutical Co Ltd Still's Disease, Adult-Onset; Solid tumours; Arthritis, Juvenile; Arthritis, Gouty; Gout Details
HMPL-004 (Hutchison Medipharma) HMPL-004 Hutchison Medipharma Ltd Details
FL-101 FL-101 Flame Biosciences Inc Details
LY 2189102 LY-2189102 Eli Lilly And Company Details
lutikizumab ABT-981 Abbvie Inc Details
Ajulemic acid DMH-11C; JBT-101; CPL-7075; DMH-THC-11-OIC; CT-3; HU-239; IP-751 Corbus Pharma Details
CYT 013 IL1bQb Kuros Biosciences Details
Efprezimod alfa CD24-Fc; HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110 Phase 1 Clinical Oncoimmune Graft vs Host Disease; Coronavirus Disease 2019 (COVID-19) Details
Ensereptide PXL-01 Phase 3 Clinical Promore Pharma Post-surgical adhesions; Cicatrix Details
Recombinant humanized monoclonal antibody antiIL-1β SSGJ-613 Phase 1 Clinical Shanghai Cp Guojian Pharmaceutical Co Ltd Tumor necrosis factor receptor associated periodic syndrome; Arthritis, Juvenile; Arthritis, Gouty; Inflammation Details
Gevokizumab XMA-005.2; AB-7; XOMA-052; S-78989; VPM-087 Phase 2 Clinical Xoma Diabetes Mellitus, Type 1; Acne Vulgaris; Stomach Neoplasms; Carcinoma, Renal Cell; Esophageal Neoplasms; Pyoderma Gangrenosum; Diabetes Mellitus, Type 2; Arthritis, Rheumatoid; Colonic Neoplasms; Colorectal Neoplasms; Uveitis; Osteoarthritis; Panuveitis; Behcet Syndrome; Labyrinth Diseases Details
CU-06 CU-06-EYE; CU-06-IBD; CU-061004; Sac-1004; CU-06-ONCO; CU-06-HAE; CU06-1004 Phase 1 Clinical Curacle Co Ltd Myocardial Infarction; Neoplasms; Lung Diseases; Stroke; Diabetic macular oedema; Colitis, Ulcerative; Angioedemas, Hereditary; Crohn Disease; Diabetic Retinopathy; Macular Degeneration Details
Goflikicept RPH-104 Phase 3 Clinical Trpharm Still's Disease, Adult-Onset; Familial Mediterranean Fever; Schnitzler Syndrome; ST Elevation Myocardial Infarction; Coronavirus Disease 2019 (COVID-19); Pericarditis; Gout Details

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