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IL-1 beta

IL-1 beta Product List

Cat. No. Species Product Description Structure Purity Feature
ILB-H4110 Human Human IL-1 beta / IL-1F2 Protein, Tag Free, low endotoxin
ILB-H4110-structure
ILB-H4110-sds
ILB-H4110-elisa_1

IL-1 beta Molecule Synonym Name

IL1B,IL-1BETA,IL1F2,IL-1¦Â

IL-1 beta Molecule Background

Interleukin-1 beta (IL-1¦Â) is also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1¦Â precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1 beta. IL1¦Â are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL1¦Á and IL1¦Â are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1¦Â is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

IL-1 beta References

IL-1 beta Related Molecule

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