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IL-1 beta

Brief Information

Name:Interleukin-1 beta
Target Synonym:IL1-BETA,IL-1,Interleukin-1beta,IL-1B,IL-1β,IL-1 β,IL1beta,Interleukin 1beta,Catabolin,IL-1 beta,IL1B,Interleukin 1 Beta,IL1F2,Pro-Interleukin-1-Beta,Preinterleukin 1 Beta,Interleukin-1 Beta
Number of Launched Drugs:8
Number of Drugs in Clinical Trials:19
Lastest Research Phase:Approved

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ACRO Quality

Part of Bioactivity data

ILB-H4110-Cell-based assay
 IL-1 beta CELL

Human IL-1 beta, premium grade (Cat. No. ILB-H4110) stimulates proliferation of D10.G4.1 cells. The specific activity of Human IL-1 beta, premium grade is>5.00 x 10^7 IU/mg, which is calibrated against WHO International Standard INTERLEUKIN-1 BETA (IL-1ß, Human rDNA derived) (NIBSC code: 86/680) (QC tested).

ILB-H51H3-SPR
 IL-1 beta SPR

Human IL-1 RII, Fc Tag (Cat. No. IL2-H4256) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human IL-1 beta, His Tag (Cat. No. ILB-H51H3) with an affinity constant of 0.571 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

ILB-H51H3-ELISA
 IL-1 beta ELISA

Immobilized Human IL-1 beta, His Tag (Cat. No. ILB-H51H3) at 10 μg/mL (100 μL/well) can bind Human IL-1 RII, Fc Tag (Cat. No. IL2-H4256) with a linear range of 2-13 ng/mL (QC tested).

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Synonym Name

IL1B,IL-1BETA,IL1F2,IL-1β

Background

Interleukin-1 beta (IL-1β) is also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1 beta.IL1β are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL1α and IL1β are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1β is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Clinical and Translational Updates

Related Molecule

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Canakinumab ACZ-885 Approved Novartis Pharma Ag Ilaris United States Muckle-Wells Syndrome (MWS); Cryopyrin-Associated Periodic Syndromes Novartis Pharma Ag 2009-06-17 Gout; Dry Eye Syndromes; Arthritis, Gouty; Cryopyrin-Associated Periodic Syndromes; Wet Macular Degeneration; Sarcoidosis, Pulmonary; Cognitive Dysfunction; Alzheimer Disease; Primary Myelofibrosis; Cardiovascular Diseases; Muscular Dystrophy, Duchenne; Urticaria; Hyperimmunoglobulin D syndrome; Pulmonary Disease, Chronic Obstructive; Lung Neoplasms; Inflammation; Diabetes Mellitus; Carcinoma, Non-Small-Cell Lung; Anemia, Sickle Cell; Thrombocythemia, Essential; Diabetic Retinopathy; Peripheral Arterial Disease; Aortic Aneurysm, Abdominal; Behcet Syndrome; Pyoderma Gangrenosum; Hepatitis, Alcoholic; Diabetes Mellitus, Type 1; Prediabetic State; Familial Mediterranean Fever; Mevalonate Kinase Deficiency; Anemia; Atherosclerosis; Schnitzler Syndrome; Polycythemia Vera; Diabetes Mellitus, Type 2; Polyarticular Juvenile Idiopathic Arthritis; Still's Disease, Adult-Onset; Myelodysplastic Syndromes; Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19); Vasculitis; Hereditary Autoinflammatory Diseases; Muckle- Details
PG-201 PG-201 Approved Viromed Layla South Korea Osteoarthritis Pmg Pharm Co Ltd 2012-01-01 Osteoarthritis, Knee; Osteoarthritis Details
Edaravone/(+)-2-Decanol SIM-071201 Approved Jiangsu Simcere Pharmaceutical Co Ltd 三贝心, 三贝欣, 先必新, Sanbexin Mainland China Stroke Nanjing Simcere Dongyuan Pharmaceutical Co Ltd 2020-07-29 Brain Infarction; Cerebral Hemorrhage; Stroke; Ischemic Stroke; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Cognition Disorders Details
Diacerein KW-4800; SF-277; Art-50 Approved Cartivix, Fisiodar, Verboril, Art, 安必丁, Artrodar, Artrolyt Metabolic Dysfunction-Associated Steatotic Liver Disease; Diabetes Mellitus, Type 2; Coronavirus Disease 2019 (COVID-19); Insulin Resistance; Epidermolysis Bullosa; Osteoarthritis, Knee; Diabetes Complications; Osteoarthritis; Obesity; Osteoarthritis, Hip; Diabetes Mellitus; Overweight Details
Andrographolide/Sodium Hydrogen Sulfite Approved Bacterial Infections Details
Edaravone/(+)-2-Decanol (Yantai Yene/Simcere) Y-2 Approved Yantai Yene Pharma Co Ltd, Simcere Pharmaceutical Group Ltd Mainland China Stroke Jiangsu Simcere Pharmaceutical Co Ltd 2024-12-01 Intracranial Hemorrhages; Stroke; Cognitive Dysfunction Details
Rilonacept RGN-303; KPL-914 Approved Regeneron Pharmaceuticals Inc Arcalyst, 炎朵 United States Cryopyrin-Associated Periodic Syndromes Kiniksa Pharmaceuticals Ltd 2008-02-27 Arthritis, Juvenile; Inflammation; Scleroderma, Diffuse; Renal Insufficiency, Chronic; Gout; Urticaria; Vascular Diseases; Cryopyrin-Associated Periodic Syndromes; Hearing Loss, Sensorineural; Genetic Diseases, Inborn; Pericarditis; Diabetes Mellitus, Type 1; Coronary Artery Disease; Deficiency of interleukin-1 receptor antagonist; Scleroderma, Systemic; Muckle-Wells Syndrome (MWS); Sarcoidosis; Atherosclerosis; Schnitzler Syndrome; Anemia; Still's Disease, Adult-Onset; Familial Mediterranean Fever Details
Thalidomide NSC-66847; NSC-527179; K-17; FPF-300; FPF300 Approved Celgene Corp Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled Mainland China Leprosy, Lepromatous; Multiple Myeloma Changzhou Pharmaceutical Factory 1982-01-01 Xerostomia; Colorectal Neoplasms; Neuroectodermal Tumors, Primitive; Prostatitis; Primary Myelofibrosis; Osteosarcoma; Cholangitis, Sclerosing; Lymphoma, Mantle-Cell; Lymphoma, Follicular; Adenocarcinoma, Clear Cell; Carcinoma, Adenosquamous; Epilepsy; Erythema Nodosum; Sarcoma; HIV Wasting Syndrome; Pancreatitis, Chronic; Sarcoma, Ewing; Arachnoiditis; Gastrointestinal Hemorrhage; Retinoblastoma; Prostatic Neoplasms; Endometriosis; Lung Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Vascular Malformations; Myelodysplastic-Myeloproliferative Diseases; Mycobacterium avium-intracellulare Infection; Amyotrophic Lateral Sclerosis; Carcinoma, Hepatocellular; Burning Mouth Syndrome; Stomatitis; Neoplasm Metastasis; Appendiceal Neoplasms; Tuberculosis; Lymphoma, Non-Hodgkin; Angiodysplasia; Pelvic Pain; Glioma; Waldenstrom Macroglobulinemia; Leprosy, Lepromatous; Endometrial Neoplasms; Uterine Neoplasms; Anemia, Sideroblastic; Ovarian Neoplasms; Gastric Antral Vascular Ectasia; Lupus Erythematosus, Discoid; Carc Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Ensereptide PXL-01 Phase 3 Clinical Promore Pharma Tissue Adhesions; Post-surgical adhesions; Cicatrix Details
Efprezimod alfa CD24-Fc; HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110 Phase 3 Clinical Oncoimmune Inc HIV Infections; Hematopoietic stem cell transplantation (HSCT); Solid tumours; Leukemia; Graft vs Host Disease; Coronavirus Disease 2019 (COVID-19); Myelodysplastic Syndromes; Dyslipidemias; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute; Melanoma Details
Lutikizumab ABT-981 Phase 3 Clinical Abbvie Inc Colitis, Ulcerative; Osteoarthritis, Knee; Hidradenitis Suppurativa; Osteoarthritis; Crohn Disease; Dermatitis, Atopic Details
Goflikicept RPH-104 Phase 3 Clinical Trpharm Familial Mediterranean Fever; Still's Disease, Adult-Onset; Schnitzler Syndrome; ST Elevation Myocardial Infarction; Pancreatitis; Coronavirus Disease 2019 (COVID-19); Pericarditis; Arthritis, Gouty; Gout Details
Canakinumab biosimilar (GENERIUM Pharmaceuticals) GNR-086 Phase 3 Clinical Generium Pharmaceuticals Still's Disease, Adult-Onset; Arthritis, Juvenile Details
Recombinant humanized monoclonal antibody antiIL-1β(Cp Guojian) SSGJ-613 Phase 3 Clinical Sunshine GuoJian Pharmaceutical (Shanghai) Co Ltd Tumor necrosis factor receptor associated periodic syndrome; Arthritis, Juvenile; Arthritis, Gouty; Gout; Inflammation Details
MAS-825 MAS-825; MAS825 Phase 3 Clinical Novartis Pharmaceuticals Corp Enterocolitis; Coronavirus Disease 2019 (COVID-19); Coronary Disease; Autoimmune Lymphoproliferative Syndrome Details
AVTX-009 FL-101; AVTX-009; LY-2189102 Phase 2 Clinical Eli Lilly And Company Diabetes Mellitus, Type 2; Arthritis, Rheumatoid; Autoimmune Diseases; Urinary Bladder Neoplasms; Hidradenitis Suppurativa; Carcinoma, Non-Small-Cell Lung Details
CU-06 CU-06-EYE; CU-06-IBD; CU-061004; Sac-1004; CU-06-ONCO; CU-06-HAE; CU06-1004 Phase 2 Clinical Curacle Co Ltd Myocardial Infarction; Neoplasms; Lung Diseases; Stroke; Diabetic macular oedema; Colitis, Ulcerative; Crohn Disease; Macular Degeneration; Angioedemas, Hereditary; Diabetic Retinopathy Details
IL1-beta receptor antagonist Therapy(Hamlet BioPharma) Phase 2 Clinical Hamlet BioPharma AB Cystitis; Pain Details
Diacerein (TWi Biotechnology/Castle Creek Pharmaceuticals) AC-201; AC-201 Controlled release tablet; AC-201 CR; AC-203; CCP 020; CCP-020 Phase 2 Clinical Twi Biotechnology Inc Diabetes Mellitus, Type 2; Epidermolysis Bullosa Simplex; Epidermolysis Bullosa; Pemphigoid, Bullous; Epidermolysis Bullosa, Junctional; Gout; Arthritis; Epidermolysis Bullosa Dystrophica Details
Gevokizumab XMA-005.2; AB-7; XOMA-052; S-78989; VPM-087; XMA-0052 Phase 1 Clinical Xoma Corp Colonic Neoplasms; Behcet Syndrome; Labyrinth Diseases; Panuveitis; Osteoarthritis; Uveitis; Colorectal Neoplasms; Cryopyrin-Associated Periodic Syndromes; Arthritis, Rheumatoid; Acne Vulgaris; Hereditary Autoinflammatory Diseases; Stomach Neoplasms; Esophageal Neoplasms; Carcinoma, Renal Cell; Pyoderma Gangrenosum; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 1 Details
DLX-2323 DLX-2323 Phase 1 Clinical Delenex Therapeutics Ag Inflammation Details
Tavo-103 Tavo103; Tavo-103; TAVO-103A; TAVO103A Phase 1 Clinical Tavotek Biotherapeutics (Hong Kong) Ltd Details

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