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Your Position: Home > IL-2

IL-2

Brief Information

Name:Interleukin-2
Target Synonym:T-cell growth factor,IL2,Interleukin 2,T Cell Growth Factor,Aldesleukin,IL-2,TCGF,Involved In Regulation Of T-Cell Clonal Expansion,Interleukin-2,Lymphokine
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:16
Lastest Research Phase:Approved

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Part of Bioactivity data

IL2-H5215-Cell-based assay
 IL-2 CELL

Human IL-2, premium grade (Cat. No. IL2-H5215) stimulates proliferation of CTLL-2 cells. The EC50 for this effect is 1.996 ng/mL, corresponding to a specific activity of  5 ⅹ10^6 IU/mg, which is calibrated against Interleukin-2 (Human, rDNA derived) (2nd International Standard) (NIBSC code: 86/500) (QC tested).

IL2-H5215-Cell-based assay
 IL-2 CELL

The activity of Human IL-2, premium grade (Cat. No.IL2-H5215) was higher than other competing products.

IL2-H4113-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IL-2 R beta, Fc Tag (Cat. No. ILB-H5253) captured on CM5 chip via anti-human IgG Fc antibody, can bind IL-2, Tag Free (Cat. No. IL2-H4113) with an affinity constant of 0.6 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

IL2-H52H8-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Biotinylated Human IL-2RB&IL-2RA&IL-2RG, Fc,Avitag&Fc,Avitag (Cat. No. ILG-H82F4) on SA Biosensor, can bind Human IL-2, His Tag (Cat. No. IL2-H52H8) with an affinity constant of 2.41 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

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Synonym Name

IL2,TCGF,lymphokine,Interleukin 2

Background

Interleukin-2 (IL-2) is an interleukin, a type of cytokine immune system signaling molecule, which is a leukocytotrophic hormone that is instrumental in the body's natural response to microbial infection and in discriminating between foreign (non-self) and self. IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes, the cells that are responsible for immunity. Mature human IL-2 shares 56% and 66% aa sequence identity with mouse and rat IL-2, respectively. Human and mouse IL-2 exhibit crossspecies activity. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is also necessary during T cell development in the thymus for the maturation of a unique subset of T cells that are termed regulatory T cells (T-regs). After exiting from the thymus, T-Regs function to prevent other T cells from recognizing and reacting against "self antigens", which could result in "autoimmunity". T-Regs do so by preventing the responding cells from producing IL-2. Thus, IL-2 is required to discriminate between self and non-self, another one of the unique characteristics of the immune system.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Thalidomide NSC-66847; NSC-527179; K-17; VP-02 Approved Celgene Corp Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled Japan Leprosy, Lepromatous Fujimoto Pharmaceutical 1982-01-01 Waldenstrom Macroglobulinemia; Sarcoma; Prostatic Neoplasms; Arachnoiditis; Cholangitis, Sclerosing; Gastrointestinal Hemorrhage; Osteosarcoma; Pancreatitis, Chronic; Retinoblastoma; Sarcoma, Ewing; Lymphoma, Mantle-Cell; Prostatitis; Colitis, Ulcerative; Colorectal Neoplasms; Neuroectodermal Tumors, Primitive; Erythema Nodosum; Leprosy, Lepromatous; Endometrial Neoplasms; Appendiceal Neoplasms; Pelvic Pain; Angiodysplasia; Glioma; Lymphoma, Non-Hodgkin; Carcinoma, Hepatocellular; Amyotrophic Lateral Sclerosis; Vascular Malformations; Crohn Disease; Precancerous Conditions; Mycobacterium avium-intracellulare Infection; Idiopathic Pulmonary Fibrosis; Leukemia; Lymphoma, B-Cell, Marginal Zone; Lymphoma, B-Cell; Liver Neoplasms; Cough; Telangiectasia, Hereditary Hemorrhagic; Mycobacterium Infections; Rhabdomyosarcoma; Arteriovenous Malformations; Inflammatory Bowel Diseases; Stomatitis, Aphthous; Gastric Antral Vascular Ectasia; Spondylitis, Ankylosing; Myelodysplastic Syndromes; HIV Infections; Coronavirus Dise Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Interleukin-2 gene therapy (St Jude Children's Research Hospital) Phase 1 Clinical St. Jude Children'S Research Hospital, National Cancer Institute Neuroblastoma Details
T20K T-20K Phase 1 Clinical Cyxone Multiple Sclerosis Details
ITI-1000 ITI-1000 Phase 2 Clinical Immunomic Therapeutics Glioblastoma Details
RG-6279 RG-6279 Phase 1 Clinical F. Hoffmann-La Roche Ltd Solid tumours Details
S-95007 S-95007 Phase 2 Clinical Laboratoires Servier Immune System Diseases; Inflammation Details
SAR-444336 SAR-444336 Phase 1 Clinical Sanofi Inflammation Details
LMBP2-specific TCR-T cell therapy (TCRCure Biopharma) Phase 2 Clinical Tcrcure Biopharma Ltd Nasopharyngeal Carcinoma Details
SHR-1916 SHR-1916 Phase 1 Clinical Jiangsu Hengrui Medicine Co Ltd Solid tumours Details
ALT-801(Altor BioScience) 264scTCR/IL-2 Altor Bioscience Details
NNC-0361-0041 NNC0361-0041; NNC-0361-0041 Phase 1 Clinical Novo Nordisk A/S Diabetes Mellitus, Type 1 Details
AU-007 BD-8; AU-007; BDG-8 Biolojic Design Inc Neoplasms Details
XTX-202 XTX-202 Details
TG-4010 VV-MUC-IL2; TG-4010 Transgene Details
HBAI-20 HBAI-20; HBAI-20-CyTuVax Cytuvax Details
PM-1016 PM1016; TILT-123 Phase 2 Clinical Tilt Biotherapeutics Ltd Solid tumours; Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Melanoma Details
Bifikafusp alfa L19-IL-2 Phase 3 Clinical Philogen Solid tumours; Carcinoma, Basal Cell; Lymphoma, Large B-Cell, Diffuse; Carcinoma, Squamous Cell; Melanoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
STK-012 STK-012 Phase 1 Clinical Synthekine Inc Solid tumours; Ovarian Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Stomach Neoplasms; Carcinoma, Transitional Cell; Microsatellite instability-high cancer; Melanoma; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Darleukin/fibromun L19-IL-2/ L19-TNF-α Phase 3 Clinical Philogen Carcinoma, Merkel Cell; Basal Cell Nevus Syndrome; Melanoma; Sarcoma, Kaposi Details
AVB-001 AVB-001 Phase 1 Clinical Avenge Bio Inc Ovarian Neoplasms Details

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