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Your Position: Home > OX40 Ligand

OX40 Ligand

Brief Information

Name:Tumor necrosis factor ligand superfamily member 4
Target Synonym:CD134L,OX-40L,TNLG2B,OX4OL,GP34,CD252 Antigen,CD134 Ligand,TAX transcriptionally-activated glycoprotein 1,Tax-Transcriptionally Activated Glycoprotein 1, 34kD,CD252,OX40 ligand,OX40L,TNFSF4,Tumor necrosis factor ligand superfamily member 4,Glycoprotein Gp34,TNF Superfamily Member 4,TXGP1,Tax-Transcriptionally Activated Glycoprotein 1 (34kD),Tumor Necrosis Factor (Ligand) Superfamily, Member 4,Tumor Necrosis Factor (Ligand) Superfamily Member 4,Tumor Necrosis Factor Superfamily Member 4,Tumor Nec
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
OXL-R5248 Rat Rat OX40 Ligand / TNFSF4 Protein, His Tag (active trimer) (MALS verified)
OXL-R5248-structure
OXL-R5248-sds
OXL-R5249 Rabbit Rabbit OX40 Ligand / TNFSF4 Protein, His Tag (active trimer) (MALS verified)
OXL-R5249-structure
OXL-R5249-sds
OXL-H82Q5 Human Biotinylated Human OX40 Ligand / TNFSF4 Protein, His,Avitag™ (active trimer) (MALS verified)
OXL-H82Q5-sds
OXL-H5266 Human Human OX40 Ligand / TNFSF4 Protein, Fc Tag (active trimer) (MALS verified)
OXL-H5266-sds
OXL-H82F4 Human Biotinylated Human OX40 Ligand / TNFSF4 Protein, Avitag™,Fc Tag
OXL-H82F4-structure
OXL-H82F4-sds
OXL-H5250 Human Human OX40 Ligand / TNFSF4 Protein, Mouse IgG2a Fc Tag, low endotoxin
OXL-H5250-structure
OXL-H5250-sds
OXL-R5259 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque OX40 Ligand / TNFSF4 Protein, Mouse IgG2a Fc Tag
OXL-R5259-structure
OXL-R5259-sds
TN4-M5241 Mouse Mouse OX40 Ligand / TNFSF4 Protein, His Tag
TN4-M5241-structure
TN4-M5241-sds
OXL-M526x Mouse Mouse OX40 Ligand / TNFSF4 Protein, Fc Tag
OXL-M526x-structure
OXL-M526x-sds
OXL-H52Q8 Human Human OX40 Ligand / TNFSF4 Protein, His Tag (active trimer) (MALS verified)
OXL-H52Q8-structure
OXL-H52Q8-sds

Part of Bioactivity data

OXL-H5250-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

FACS assay shows that recombinant Human OX40 Ligand, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. OXL-H5250) can bind to 293T cell overexpressing human OX40. The concentration of OX40 Ligand is 0.003 μg/ml (Routinely tested).

Protocol
OXL-H5250-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

FACS analysis shows that the binding of Human OX40 Ligand, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. OXL-H5250) to 293T overexpressing OX40 was inhibited by increasing concentration of neutralizing anti-OX40 antibody. The concentration of OX40 Ligand used is 0.002 μg/ml. IC50=3.021 μg/ml (Routinely tested).

Protocol
OXL-H5250-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human OX40 Ligand, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. OXL-H5250) on Protein A Biosensor, can bind Human OX40, His Tag (Cat. No. OX0-H5224) with an affinity constant of 2 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
OXL-H52Q8-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Biotinylated Human OX40, Avitag,His Tag (Cat. No. TN4-H82E4) on SA Biosensor, can bind Human OX40 Ligand, His Tag (active trimer) (Cat. No. OXL-H52Q8) with an affinity constant of 0.127 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

OX40L,TNFSF4,CD252,Glycoprotein Gp34,TXGP1,CD134 ligand,CD134L

Background

Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.

Clinical and Translational Updates

Related Molecule

OX40

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
SAR-443726 SAR-443726 Phase 1 Clinical Sanofi Dermatitis, Atopic Details
RP-3 RP-3 Replimune Inc Details
anti-cancer mRNA therapeutics (Moderna Therapeutics) mRNA-2752 Moderna Inc, Astrazeneca Plc Details
Oxelumab R-4930; RG-4930; Roche-4; RO-4989991; OX40L-huMab; huMAb-OX40L Genentech Inc, Genmab Details
Oncolytic virus cancer therapeutics (DNAtrix) MYX-135; DNX-2440; DNX-2450 Phase 1 Clinical Dnatrix Inc Liver Neoplasms; Carcinoma, Renal Cell; Stomach Neoplasms; Pancreatic Neoplasms; Colonic Neoplasms; Glioblastoma; Sarcoma; Breast Neoplasms; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Carcinoma, Squamous Cell; Melanoma Details
Amlitelimab KY-1005; SAR-445229 Phase 2 Clinical Kymab, Sanofi Immune System Diseases; Asthma; Dermatitis, Atopic; Eczema Details

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