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OX40 Ligand

OX40 Ligand Molecule Information

Name:Tumor necrosis factor ligand superfamily member 4
Target Synonym:Glycoprotein Gp34;OX40L;TNFSF4;TXGP1;CD_antigen=CD252;TAX transcriptionally-activated glycoprotein 1;Tumor necrosis factor ligand superfamily member 4;OX40 ligand
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase ?

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OX40 Ligand Molecule Synonym Name

OX40L,TNFSF4,CD252,Glycoprotein Gp34,TXGP1

OX40 Ligand Molecule Background

Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.

OX40 Ligand References

OX40 Ligand Related Molecule

OX40 Ligand Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
KY-1005 KY-1005 Phase Ⅱ Kymab Autoimmune diseases, Atopic dermatitis Details
Oxelumab R-4930; RG-4930; RO-4989991; Roche-4; huMAb-OX40L; OX40L-huMab Phase Ⅱ Genentech, Genmab Allergic asthma Details
mRNA-2416 mRNA-2416; OX40L mRNA - Moderna Therpeutics Phase Ⅱ Moderna Therapeutics Solid tumours, Lymphoma Details

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