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Brief Information

Name:Poliovirus receptor
Target Synonym:PVR Cell Adhesion Molecule,Poliovirus receptor,PVS,NECL-5,PVR,Nectin-Like Protein 5,CD155 Antigen,Nectin-Like 5,CD155,NECL5,TAGE4,HVED
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

SCRAJ-STT076-Cell-based assay

Expression analysis of human CD155 on Raji/Human CD155 Stable Cell by FACS.
Raji/Human CD155 Stable Cell Line or negative control cell were stained with PE-labeled anti-Human CD155 antibody.

CD5-H5254-Cell-based assay

FACS assay shows that Human CD155, Mouse IgG2a Fc Tag (Cat. No. CD5-H5254) can bind to 293T cell overexpressing human TIGIT. The concentration of CD155 is 1 μg/mL (Routinely tested).

 CD155 BLI

Loaded Human DNAM-1, Fc Tag (Cat. No. DN1-H5257) on Protein A Biosensor, can bind Rhesus macaque CD155, His Tag (Cat. No. CD5-R52H5) with an affinity constant of 0.47 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

 CD155 BLI

Loaded Biotinylated Human CD155, His,Avitag (Cat. No. CD5-H82E3) on SA Biosensor, can bind Human TIGIT, His Tag with an affinity constant of 0.37 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

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Synonym Name



CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155/PVR was originally isolated based on its ability to mediate polio virus attachment to host cells. The fulllength (or CD155 alpha isoform) is synthesized as a 417 amino acid (aa) precursor that contains a 20 aa signal sequence, a 323 aa extracellular region, a 24 aa TM segment and a 50 aa cytoplasmic tail. The extracellular region contains one N terminal V type and two C2 type Ig like domains. CD155 is a transmembrane protein with 3 extracellular immunoglobulin-like domains, D1-D3, where D1 is recognized by the virus. Low resolution structures of CD155 complexed with poliovirus have been obtained using electron microscopy while a high resolution structures of theectodomain D1 and D2 of CD155 were solved by x-ray crystallography.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Lerapolturev Phase 2 Clinical National Cancer Institute, Istari Oncology Inc, Duke University Medical Center Ependymoma; Medulloblastoma; Solid tumours; Glioblastoma; Oligodendroglioma; Urinary Bladder Neoplasms; Brain Neoplasms; Breast Neoplasms; Gliosarcoma; Astrocytoma; Carcinoma, Embryonal; Glioma; Melanoma Details
NTX-1088 Phase 1 Clinical Nectin Therapeutics Ltd Solid tumours; Neoplasms; Neoplasm Metastasis Details

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