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Your Position: Home > CD155

CD155

Brief Information

Name:Poliovirus receptor
Target Synonym:PVR Cell Adhesion Molecule,Poliovirus receptor,PVS,NECL-5,PVR,Nectin-Like Protein 5,CD155 Antigen,Nectin-Like 5,CD155,NECL5,TAGE4,HVED
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
CD5-R82E4 Rhesus macaque Biotinylated Rhesus macaque CD155 / PVR Protein, His,Avitag™ (MALS verified)
CD5-R82E4-structure
CD5-R82E4-sds
CD5-R5253 Rhesus macaque Rhesus macaque CD155 / PVR Protein, Fc Tag (MALS verified)
CD5-R5253-structure
CD5-R5253-sds
CD5-M82E4 Mouse Biotinylated Mouse CD155 / PVR Protein, His,Avitag™
CD5-M82E4-structure
CD5-M82E4-sds
CD5-M52H6 Mouse Mouse CD155 / PVR Protein, His Tag (MALS verified)
CD5-M52H6-structure
CD5-M52H6-sds
SCRAJ-STT076 Human Raji/Human CD155 Stable Cell Line
CD5-R52H5 Rhesus macaque Rhesus macaque CD155 / PVR Protein, His Tag (MALS verified)
CD5-R52H5-structure
CD5-R52H5-sds
CD5-H82E3 Human Biotinylated Human CD155 / PVR Protein, His,Avitag™ (MALS verified)
CD5-H82E3-structure
CD5-H82E3-sds
CD5-M82F7 Mouse Biotinylated Mouse CD155 / PVR Protein, Fc,Avitag™ (MALS verified)
CD5-M82F7-structure
CD5-M82F7-sds
CD5-M5254 Mouse Mouse CD155 / PVR Protein, Mouse IgG2a Fc Tag (MALS verified)
CD5-M5254-structure
CD5-M5254-sds
CD5-H5254 Human Human CD155 / PVR Protein, Mouse IgG2a Fc Tag, low endotoxin
CD5-H5254-structure
CD5-H5254-sds
CD5-H82F6 Human Biotinylated Human CD155 / PVR Protein, Fc,Avitag™ (MALS verified)
CD5-H82F6-structure
CD5-H82F6-sds
CD5-H5251 Human Human CD155 / PVR Protein, Fc Tag
CD5-H5251-structure
CD5-H5251-sds
CD5-H5223 Human Human CD155 / PVR Protein, His Tag (MALS verified)
CD5-H5223-structure
CD5-H5223-sds
ACRO Quality

Part of Bioactivity data

SCRAJ-STT076-Cell-based assay
CD155 FACS

Expression analysis of human CD155 on Raji/Human CD155 Stable Cell by FACS.
Raji/Human CD155 Stable Cell Line or negative control cell were stained with PE-labeled anti-Human CD155 antibody.

Protocol
CD5-H5254-Cell-based assay
CD155 FACS

FACS assay shows that Human CD155, Mouse IgG2a Fc Tag (Cat. No. CD5-H5254) can bind to 293T cell overexpressing human TIGIT. The concentration of CD155 is 1 μg/mL (Routinely tested).

Protocol
CD5-R52H5-BLI
CD155 BLI

Loaded Human DNAM-1, Fc Tag (Cat. No. DN1-H5257) on Protein A Biosensor, can bind Rhesus macaque CD155, His Tag (Cat. No. CD5-R52H5) with an affinity constant of 0.47 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
CD5-H82E3-BLI
CD155 BLI

Loaded Biotinylated Human CD155, His,Avitag (Cat. No. CD5-H82E3) on SA Biosensor, can bind Human TIGIT, His Tag with an affinity constant of 0.37 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Customer Reviews

Synonym Name

PVR,FLJ25946,PVS,CD155,TAGE4,HVED,NECL5

Background

CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155/PVR was originally isolated based on its ability to mediate polio virus attachment to host cells. The fulllength (or CD155 alpha isoform) is synthesized as a 417 amino acid (aa) precursor that contains a 20 aa signal sequence, a 323 aa extracellular region, a 24 aa TM segment and a 50 aa cytoplasmic tail. The extracellular region contains one N terminal V type and two C2 type Ig like domains. CD155 is a transmembrane protein with 3 extracellular immunoglobulin-like domains, D1-D3, where D1 is recognized by the virus. Low resolution structures of CD155 complexed with poliovirus have been obtained using electron microscopy while a high resolution structures of theectodomain D1 and D2 of CD155 were solved by x-ray crystallography.

Clinical and Translational Updates

Related Molecule

TIGIT DNAM-1

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Lerapolturev Phase 2 Clinical National Cancer Institute, Istari Oncology Inc, Duke University Medical Center Medulloblastoma; Ependymoma; Solid tumours; Glioblastoma; Oligodendroglioma; Urinary Bladder Neoplasms; Breast Neoplasms; Brain Neoplasms; Gliosarcoma; Astrocytoma; Glioma; Carcinoma, Embryonal; Melanoma Details
NTX-1088 Phase 1 Clinical Nectin Therapeutics Ltd Solid tumours; Neoplasms; Neoplasm Metastasis Details

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