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CD155

CD155 Part of Bioactivity data

CD5-H5254-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

FACS assay shows that Human CD155, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. CD5-H5254) can bind to 293T cell overexpressing human TIGIT. The concentration of CD155 is 1 μg/mL (Routinely tested).

CD5-H5254-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

FACS analysis shows that the binding of Human CD155, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. CD5-H5254) to 293T overexpressing TIGIT was inhibited by increasing concentration of neutralizing Anti-Human TIGIT MAb. The concentration of CD155 used is 1 μg/mL. The IC50 is 0.1413 μg/mL (Routinely tested).

CD5-R52H5-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human DNAM-1, Fc Tag (Cat. No. DN1-H5257) on Protein A Biosensor, can bind Rhesus macaque CD155, His Tag (Cat. No. CD5-R52H5) with an affinity constant of 0.47 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

CD5-H5254-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human CD155, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. CD5-H5254) on Protein A Biosensor, can bind Human TIGIT, His Tag (Cat. No. TIT-H52H3) with an affinity constant of 0.24 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

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CD155 Molecule Synonym Name

PVR,FLJ25946,PVS,CD155,TAGE4,HVED,NECL5

CD155 Molecule Background

CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155/PVR was originally isolated based on its ability to mediate polio virus attachment to host cells. The fulllength (or CD155 alpha isoform) is synthesized as a 417 amino acid (aa) precursor that contains a 20 aa signal sequence, a 323 aa extracellular region, a 24 aa TM segment and a 50 aa cytoplasmic tail. The extracellular region contains one N terminal V type and two C2 type Ig like domains. CD155 is a transmembrane protein with 3 extracellular immunoglobulin-like domains, D1-D3, where D1 is recognized by the virus. Low resolution structures of CD155 complexed with poliovirus have been obtained using electron microscopy while a high resolution structures of theectodomain D1 and D2 of CD155 were solved by x-ray crystallography.

CD155 References

CD155 Related Molecule

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