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B7-H3

B7-H3 Molecule Information

Name:CD276 antigen
Target Synonym:Costimulatory molecule;4Ig-B7-H3;B7 homolog 3;B7H3;B7-H3;CD276
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Phase ?

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B7-H3 Molecule Synonym Name

B7-H3,CD276,B7 homolog 3

B7-H3 Molecule Background

B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. It could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.

B7-H3 References

B7-H3 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Monoclonal antibody 8H9 I-131 131-I-8H9; 8H9-MAb; 131I-8H9-(B7-H3) Phase Ⅲ Memorial Sloan-Kettering Cancer Center, Y-mAbs Neuroblastoma Details
DS-5573 DS-5573; DS-5573a Phase Ⅰ Daiichi Sankyo Solid tumours Details
Enoblituzumab MGA-271,MGA271 Phase Ⅱ MacroGenics Prostate cancer Details
Monoclonal antibody 8H9 I-124 124I-8H9; 124I-8H9-(B7-H3) Phase Ⅱ Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College Glioma Details
MGC-018 MGC-018 Phase Ⅱ MacroGenics Solid tumours Details
B7-H3 CAR-T cell therapy (Zhejiang University) Phase Ⅱ Zhejiang University Glioblastoma Details
DS-7300 DS-7300 Phase Ⅱ Daiichi Sankyo Solid tumours Details
Orlotamab MGD-009; B7-H3 x CD3 Phase Ⅰ MacroGenics Solid tumours Details

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