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Your Position: Home > IL23A & IL12B

IL23A & IL12B

Brief Information

Name:Interleukin-23
Target Synonym:Interleukin-23
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:15
Lastest Research Phase:Approved

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Part of Bioactivity data

ILB-H82W6-Cell-based assay
 IL23A & IL12B CELL

Biotinylated Human IL-23A&IL-12B Heterodimer Protein, His,Avitag&Tag Free (Cat. No. ILB-H82W6) stimulates secretion of IL-17 by mousespleen cells. The ED50 for this effect is 0.191-0.2173 ng/mL (Routinely tested).

ILB-H82W6-Cell-based assay
 IL23A & IL12B CELL

Cell based assay shows that the secretion of IL-17 induced by Biotinylated Human IL-23A&IL-12B Heterodimer Protein, His,Avitag&Tag Free (Cat. No. ILB-H82W6) is inhibited by increasing concentration of the anti-human IL-23 neutralizing antibody. The IC50 is between 0.25-1.40 ng/mL (Routinely tested).

ILB-H82W6-SPR
 IL23A & IL12B SPR

Captured Biotinylated Human IL-23A&IL-12B Heterodimer Protein, His,Avitag&Tag Free (Cat. No. ILB-H82W6) on Biotin CAP - Series S sensor Chip can bind Human IL-23 R, His Tag (Cat. No. ILR-H52H4) affinity constant of 4.77 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

ILB-H52W5-SPR
 IL23A & IL12B SPR

Captured Human IL-23 R, Fc Tag (Cat. No. ILR-H5254) on CM5 chip via anti-human IgG Fc antibodies surface can bind Human IL-23A&IL-12B Heterodimer Protein, His Tag&Tag Free (Cat. No. ILB-H52W5) with an affinity constant of 5.36 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

IL23A & IL12B Molecule Synonym Name

IL-23 alpha & IL-12 beta

IL23A & IL12B Molecule Background

Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

IL23A & IL12B References

Related Molecule

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Ustekinumab CNTO-1275; C-340; AVT-04 Approved Janssen Global Services Llc 喜达诺, Stelara United States Plaque psoriasis Janssen Biotech Inc 2009-09-25 Multiple Sclerosis; Dermatitis, Atopic; Plaque psoriasis; Crohn Disease; Common Variable Immunodeficiency; Uveitis; Hidradenitis Suppurativa; Arthritis, Psoriatic; Colitis, Ulcerative; Lupus Erythematosus, Systemic; Takayasu Arteritis; Psoriasis; Liver Cirrhosis, Biliary; Arthritis, Juvenile; Ichthyosis; Sjogren's Syndrome; Pouchitis; Inflammatory Bowel Diseases; Type I Leukocyte Adhesion Defect; Dermatomyositis; Non-radiographic axial spondyloarthritis; Polymyositis; Diabetes Mellitus, Type 1 Details
Ustekinumab biosimilar(Amgen) ABP-654 Approved Amgen Inc Wezlana, WEZLANA United States Arthritis, Psoriatic; Plaque psoriasis; Colitis, Ulcerative; Crohn Disease Amgen Inc 2023-10-31 Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Plaque psoriasis; Crohn Disease Details
Ustekinumab CNTO-1275; C-340; AVT-04 Approved Janssen Global Services Llc 喜达诺, Stelara United States Plaque psoriasis Janssen Biotech Inc 2009-09-25 Multiple Sclerosis; Dermatitis, Atopic; Plaque psoriasis; Crohn Disease; Common Variable Immunodeficiency; Uveitis; Hidradenitis Suppurativa; Arthritis, Psoriatic; Colitis, Ulcerative; Lupus Erythematosus, Systemic; Takayasu Arteritis; Psoriasis; Liver Cirrhosis, Biliary; Arthritis, Juvenile; Ichthyosis; Sjogren's Syndrome; Pouchitis; Inflammatory Bowel Diseases; Type I Leukocyte Adhesion Defect; Dermatomyositis; Non-radiographic axial spondyloarthritis; Polymyositis; Diabetes Mellitus, Type 1 Details
Ustekinumab biosimilar(Amgen) ABP-654 Approved Amgen Inc Wezlana, WEZLANA United States Arthritis, Psoriatic; Plaque psoriasis; Colitis, Ulcerative; Crohn Disease Amgen Inc 2023-10-31 Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Plaque psoriasis; Crohn Disease Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
anti-cancer mRNA therapeutics (Moderna Therapeutics) mRNA-2752 Phase 1 Clinical Moderna Inc, Astrazeneca Plc Solid tumours; Squamous Cell Carcinoma of Head and Neck; Neoplasms; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Lymphoma, Non-Hodgkin; Lymphoma; Melanoma; Carcinoma, Non-Small-Cell Lung Details
Ustekinumab Biosimilar(Celltrion) CT-P43 Phase 3 Clinical Celltrion Inc Psoriasis Details
SOR-102 SOR-102 Phase 1 Clinical Sorriso Pharmaceuticals Inc Inflammatory Bowel Diseases; Colitis, Ulcerative Details
LY-900021 LY-900021 Phase 1 Clinical Halozyme Therapeutics Inc, Eli Lilly And Company Details
IL-23/CGRP bispecific antibody (Lilly) Phase 1 Clinical Eli Lilly And Company Autoimmune Diseases Details
Ustekinumab Biosimilar (NeuClone/Serum Institute of India) Phase 1 Clinical Neuclone, Serum Institute Of India Ltd Autoimmune Diseases Details
Ustekinumab biosimilar (BioFactura) BFI-751 Phase 1 Clinical BioFactura Australia Pty Ltd Psoriasis Details
Ustekinumab Biosimilar (qyuns) QX-001-S; HDM-3001; QX-001S Phase 3 Clinical Qyuns Therapeutics Co Ltd Psoriasis; Plaque psoriasis Details
Brazikumab AMG-139; MEDI-2070; Anti-IL-23-MAb (Amgen) Phase 2 Clinical Amgen Inc Inflammatory Bowel Diseases; Psoriasis; Colitis, Ulcerative; Crohn Disease Details
Ustekinumab biosimilar(CSPC Pharma) SYSA-1902 Phase 3 Clinical Jushi Biopharmaceutical Co Ltd Psoriasis; Plaque psoriasis Details
Ustekinumab biosimilar(Formycon) FYB-202 Phase 3 Clinical Formycon Psoriasis Details
Kagocel Clinical Nearmedic Plus Llc Respiratory Tract Infections; Respirovirus Infections; Influenza, Human Details
Ustekinumab biosimilar(Rani Therapeutics) RT-111 Phase 1 Clinical Rani Therapeutics Llc Psoriasis Details
anti-cancer mRNA therapeutics (Moderna Therapeutics) mRNA-2752 Phase 1 Clinical Moderna Inc, Astrazeneca Plc Solid tumours; Squamous Cell Carcinoma of Head and Neck; Neoplasms; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Lymphoma, Non-Hodgkin; Lymphoma; Melanoma; Carcinoma, Non-Small-Cell Lung Details
Ustekinumab Biosimilar(Celltrion) CT-P43 Phase 3 Clinical Celltrion Inc Psoriasis Details
SOR-102 SOR-102 Phase 1 Clinical Sorriso Pharmaceuticals Inc Inflammatory Bowel Diseases; Colitis, Ulcerative Details
LY-900021 LY-900021 Phase 1 Clinical Halozyme Therapeutics Inc, Eli Lilly And Company Details
IL-23/CGRP bispecific antibody (Lilly) Phase 1 Clinical Eli Lilly And Company Autoimmune Diseases Details
Ustekinumab Biosimilar (NeuClone/Serum Institute of India) Phase 1 Clinical Neuclone, Serum Institute Of India Ltd Autoimmune Diseases Details
Ustekinumab biosimilar (BioFactura) BFI-751 Phase 1 Clinical BioFactura Australia Pty Ltd Psoriasis Details
Ustekinumab Biosimilar (qyuns) QX-001-S; HDM-3001; QX-001S Phase 3 Clinical Qyuns Therapeutics Co Ltd Psoriasis; Plaque psoriasis Details
Brazikumab AMG-139; MEDI-2070; Anti-IL-23-MAb (Amgen) Phase 2 Clinical Amgen Inc Inflammatory Bowel Diseases; Psoriasis; Colitis, Ulcerative; Crohn Disease Details
Ustekinumab biosimilar(CSPC Pharma) SYSA-1902 Phase 3 Clinical Jushi Biopharmaceutical Co Ltd Psoriasis; Plaque psoriasis Details
Ustekinumab biosimilar(Formycon) FYB-202 Phase 3 Clinical Formycon Psoriasis Details
Kagocel Clinical Nearmedic Plus Llc Respiratory Tract Infections; Respirovirus Infections; Influenza, Human Details
Ustekinumab biosimilar(Rani Therapeutics) RT-111 Phase 1 Clinical Rani Therapeutics Llc Psoriasis Details

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