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Siglec-3

Siglec-3 Molecule Information

Name:Myeloid cell surface antigen CD33
Target Synonym:Sialic acid-binding Ig-like lectin 3?Myeloid cell surface antigen CD33?Siglec-3?gp67?CD33?CD_antigen=CD33?SIGLEC3
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:27
Lastest Research Phase:Approved

Siglec-3 Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
CD3-H5259 Human Human Siglec-3 / CD33 Protein, Llama IgG2b Fc Tag, low endotoxin
CD3-H5259-structure
CD3-H5259-sds
CD3-H5259-elisa_1
CD3-H82E7 Human Biotinylated Human Siglec-3 / CD33 Protein, Avitag™,His Tag
CD3-H82E7-structure
CD3-H82E7-sds
CD3-H82E7-elisa_1
CD3-H5257 Human Human Siglec-3 / CD33 Protein, Fc Tag
CD3-H5257-structure
CD3-H5257-sds
CD3-H5257-elisa_1
CD3-H5226 Human Human Siglec-3 / CD33 Protein, His Tag
CD3-H5226-structure
CD3-H5226-sds
CD3-H5226-elisa_1

Siglec-3 Molecule Synonym Name

CD33,SIGLEC3,gp67

Siglec-3 Molecule Background

Myeloid

Siglec-3 Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Gemtuzumab ozogamicin CMA-676; CL-555201; CDP-771; WAY-CMA-676; hP67.6-calicheamicin,CMA676,CL555201 Approved Pfizer, UCB MYLOTARG fda Acute myeloid Leukemia (AML) WYETH PHARMS INC 2000-05-17 Acute myeloid Leukemia (AML) Details

Siglec-3 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Lintuzumab Ac-225 (Actinium Pharmaceuticals) 225Ac-HuM-195; AC225-MOAB-M195; HuM195-Ac-225 Phase Ⅱ PDL BioPharma, Actinium Pharmaceuticals, Memorial Sloan-Kettering Cancer Center, University of Texas M. D. Anderson Cancer Center Acute myeloid Leukemia (AML) Details
HuM195-gelonin immunotoxin Phase Ⅰ Memorial Sloan-Kettering Cancer Center, Banner MD Anderson Cancer Center Myelodysplastic syndrome (MDS), Acute myeloid Leukemia (AML), Chronic myeloid leukemia (CML ) Details
Anti-CD33/anti-FcgammaRI bispecific antibody (UCSD) Phase Ⅰ University of California San Diego Acute myeloid Leukemia (AML) Details
AVE-9633 AVE-9633 Phase Ⅰ ImmunoGen, Sanofi Acute myeloid Leukemia (AML) Details
Lintuzumab-gelonin conjugate Phase Ⅰ University of Texas M. D. Anderson Cancer Center Myelodysplastic syndrome (MDS), Acute myeloid Leukemia (AML), Chronic myeloid leukemia (CML ) Details
OXS-3550 GTB-3550; OXIS-3550; OXS-3550; OXS-3550-TriKE Preclinical University of Minnesota, Oxis Biotech B-cell lymphoma Details
OXS-C3550 OXS-3350; OXS-C3550 Preclinical University of Minnesota, GT Biopharma Acute myeloid Leukemia (AML) Details
Oncolysin M Oncolysin-M Phase Ⅰ ImmunoGen, Dana-Farber Cancer Institute Acute myeloid Leukemia (AML) Details
Lintuzumab SGN-33 Phase Ⅱ PDL BioPharma, Seattle Genetics Myelodysplastic syndrome (MDS), Acute granulocytic leukemia Details
CLL-1-CD33 cCART cell therapy (iCell Gene Therapeutics) CLL-1-CD33 cCAR,CLL-1 CD33 cCAR Phase Ⅰ iCell Gene Therapeutics Acute myeloid Leukemia (AML) Details
ICG-136 ICG-136 Phase Ⅰ iCell Gene Therapeutics, Chengdu Military General Hospital Acute myeloid Leukemia (AML) Details
AMG-673 AMG-673; AMG673 Phase Ⅰ Amgen Acute myeloid Leukemia (AML) Details
Anti-CD33 chimeric antigen receptor T cell therapy (Intrexon/ZIOPHARM Oncology) Phase Ⅰ Ziopharm Oncology, Intrexon Corporation Acute myeloid Leukemia (AML) Details
CLL1-CD33 cCART cell therapy (iCell Gene Therapeutics) CLL1-CD33-cCAR Phase Ⅰ iCell Gene Therapeutics, Chengdu Military General Hospital Acute myeloid Leukemia (AML) Details
M195-Y-90 Phase Ⅰ Nonindustrial source Acute myeloid Leukemia (AML), Cancer Details
M-195 Phase Ⅲ Nonindustrial source, PDL BioPharma, Akzo Nobel Myelodysplastic syndrome (MDS), Myeloid leukemia, Acute myeloid Leukemia (AML), Acute promyelocytic leukemia (APL) Details
Anti-CD33 CAR T cell therapy (Wuhan Bio-Raid) Phase Not Specified Wuhan Bio-Raid Biotechnology Acute myeloid Leukemia (AML) Details
IMGN-779 IMGN-779 Phase Ⅰ ImmunoGen Myelodysplastic syndrome (MDS), Acute myeloid Leukemia (AML) Details
GEM-333 GEM-333 Phase Ⅰ GEMoaB Monoconals Acute myeloid Leukemia (AML) Details
Lintuzumab Bi-213 Phase Ⅱ PDL BioPharma, Actinium Pharmaceuticals Acute myeloid Leukemia (AML) Details
Vadastuximab talirine 33-A; SGN-CD33A Phase Ⅲ Seattle Genetics Myelodysplastic syndrome (MDS), Acute myeloid Leukemia (AML) Details
AMV-564 T-564; AMV-564 Phase Ⅰ Amphivena Therapeutics Myelodysplastic syndrome (MDS), Acute myeloid Leukemia (AML) Details
Anti-CD33 CAR-NK cell therapy (PersonGen Biomedicine) Phase Ⅱ PersonGen Biomedicine Acute myeloid Leukemia (AML) Details
AFM-24 AFM-12; AFM-18; AFM-20; AFM-21; AFM-22; AFM-24; AFM-24+; AFM-26; AFM-26+ Preclinical Affimed, Amphivena Therapeutics Colorectal cancer, Lung cancer, Acute myeloid Leukemia (AML), Head and neck cancer, Cancer Details
AL-003 AL-003 Phase Ⅰ Abbvie, Alector Alzheimer's disease (AD) Details
CART-33 (Chinese PLA General Hospital) Phase Ⅱ General Hospital of the People's Liberation Army Acute myeloid Leukemia (AML) Details
AMG-330 AMG-330; MT-114  Phase Ⅰ Amgen Acute myeloid Leukemia (AML) Details

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