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Your Position: Home > Fc gamma RI / CD64

Fc gamma RI / CD64

Brief Information

Name:High affinity immunoglobulin gamma Fc receptor I
Target Synonym:IgG Fc Receptor I,FcgammaRIa,High Affinity Immunoglobulin Gamma Fc Receptor I,Fc-Gamma Receptor I A1,CD64 Antigen,CD64A,CD64,FCG1,FCGR1,IGFR1,FcRI,Fc-gamma RIA,Fc-gamma RI,Fc Fragment Of IgG Receptor Ia,Fc Fragment Of IgG, High Affinity Ia, Receptor (CD64),Fc Gamma Receptor Ia,FCGR1A,Fc Fragment Of IgG, High Affinity Ia, Receptor For (CD64)
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Discontinued

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Part of Bioactivity data


Cynomolgus CD64, His Tag (Cat. No. FCA-C52H6) captured on CM5 chip via anti-His antibody can bind Herceptin with an affinity constant of 2.34 nM as determined in a SPR assay (Biacore 8K) (QC tested).


Biotinylated Mouse CD64, His,Avitag (Cat. No. CD4-M82E7) captured on Biotin CAP - Series S sensor Chip can bind Herceptin with an affinity constant of 59.8 nM as determined in a SPR assay (Biacore T200) (QC tested).

Synonym Name



Receptors that recognize the Fc portion of IgG are divided into three groups designated Fc gamma RI, RII, and RIII, also known respectively as CD64, CD32, and CD16. Fc gamma RI binds IgG with high affinity and functions during early immune responses. Fc gamma RII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses.High affinity immunoglobulin gamma Fc receptor I is also known as FCGR1A, FCG1, FCGR1, CD64 and IGFR1, is a type of integral membrane glycoprotein that binds monomeric IgG-type antibodies with high affinity, which belongs to the immunoglobulin superfamily or FCGR1 family. FCGR1A / CD64 contains 3 Ig-like C2-type (immunoglobulin-like) domains. CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines like IFNγ and G-CSF can induce CD64 expression on these cells.

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