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CD27 Ligand

CD27 Ligand Molecule Information

Name:CD70 antigen
Target Synonym:CD27-L;Tumor necrosis factor ligand superfamily member 7;CD70;CD27L;CD27LG;TNFSF7;CD27 ligand
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Phase ?

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CD27 Ligand Molecule Synonym Name


CD27 Ligand Molecule Background

Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFN¦Ã production, on NK cells.

CD27 Ligand References

CD27 Ligand Related Molecule

CD27 Ligand Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AMG-172 AMG-172 Phase Ⅰ Amgen Renal carcinoma Details
MDX-1411 MDX-1411 Phase Ⅰ Medarex Renal carcinoma Details
SGN-CD70A SGN-CD70A; SGN-70A; SGNCD-70A Phase Ⅰ Seattle Genetics Non-Hodgkin's lymphoma (NHL), Renal carcinoma Details
Vorsetuzumab mafodotin SGN-75 Phase Ⅰ Seattle Genetics Non-Hodgkin's lymphoma (NHL), Renal carcinoma Details
Anti-CD70 CAR T cell therapy (Allogene Therapeutics) Preclinical Allogene Therapeutics Renal cell carcinoma, Non-Hodgkin's lymphoma (NHL) Details
Cusatuzumab ARGX-110; JNJ-4550 Phase Ⅱ arGEN-X, Janssen Myelodysplastic syndrome (MDS), Cutaneous T cell lymphoma (CTCL), hematological malignancies, Solid tumours, Acute myeloid Leukemia (AML) Details
Vorsetuzumab SGN-70,SGN70 Phase Ⅰ Seattle Genetics Plaque psoriasis, Autoimmune diseases, Inflammation, Cancer Details
MDX-1203 BMS-936561; MDX-1203 Phase Ⅰ Bristol-Myers Squibb Non-Hodgkin B-cell lymphomas, Renal carcinoma Details

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