Immobilized Cynomolgus CD27 Ligand, His Tag (Cat. No. CDL-C5244) at 2 μg/mL (100 μL/well) can bind Cynomolgus / Rhesus macaque CD27, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. CD7-C5259) with a linear range of 1-8 ng/mL (QC tested).
The purity of FITC-Labeled Human CD27 Ligand, His,Flag Tag (Cat. No. CDD-HF2D4) was more than 90% and the molecular weight of this protein is around 65-75 kDa verified by SEC-MALS.
Measured by its binding ability in a functional ELISA. Immobilized Anti-CD27 Ligand Antibody, Human IgG1 at 1 μg/mL (100 μL/well) can bind FITC-Labeled Human CD27 Ligand, His,Flag Tag (Cat. No. CDD-HF2D4) with a linear range of 0.039-0.156 μg/mL (QC tested).
CD27 Ligand Molecule Synonym Name
CD70,CD27LG,TNFSF7,TNFSF7G,CD27L
CD27 Ligand Molecule Background
Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.
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