0
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > CD27 Ligand

CD27 Ligand

CD27 Ligand Molecule Information

Name:CD70 antigen
Target Synonym:CD27-L;Tumor necrosis factor ligand superfamily member 7;CD70;CD27L;CD27LG;TNFSF7;CD27 ligand
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Phase ?

CD27 Ligand Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
CDD-HF2D4 Human FITC-Labeled Human CD27 Ligand / CD70 Protein, His,Flag Tag active trimer (MALS verified)
CDD-HF2D4-structure
CDD-HF2D4-sds
CDD-HF2D4-elisa_1
CDL-C5244 Cynomolgus Cynomolgus CD27 Ligand / CD70 Protein, His Tag (active trimer) (MALS verified)
CDL-C5244-structure
CDL-C5244-sds
CDL-C5244-elisa_1
CDL-H82D7 Human Biotinylated Human CD27 Ligand / CD70 Protein, His,Avitag™,Flag Tag (active trimer) (MALS verified)
CDL-H82D7-sds
CDL-H82D7-elisa_1
CDL-H52Da Human Human CD27 Ligand / CD70 Protein, His,Flag Tag (active trimer) (MALS verified)
CDL-H52Da-sds
CDL-H52Da-elisa_1
CDL-H5266 Human Human CD27 Ligand / CD70 Protein, Fc Tag (active trimer) (MALS verified)
CDL-H5266-sds
CDL-H5266-elisa_1
CDL-H82Q9 Human Biotinylated Human CD27 Ligand / CD70 Protein, His,Avitag™
CDL-H82Q9-structure
CDL-H82Q9-sds
CDL-H82Q9-elisa_1
CDL-M82Qb Mouse Biotinylated Mouse CD27 Ligand / CD70 Protein, His,Avitag™
CDL-M82Qb-structure
CDL-M82Qb-sds
CDL-M82Qb-elisa_1
CDL-H5246 Human Human CD27 Ligand / CD70 Protein, His Tag
CDL-H5246-structure
CDL-H5246-sds
CDL-H5246-elisa_1
CDL-M5245 Mouse Mouse CD27 Ligand / CD70 Protein, His Tag (active trimer) (MALS verified)
CDL-M5245-structure
CDL-M5245-sds
CDL-M5245-hplc
CDL-M5245-elisa_1
CDL-H525a Human Human CD27 Ligand / CD70 Protein, Mouse IgG2a Fc Tag, low endotoxin
CDL-H525a-structure
CDL-H525a-sds
CDL-H525a-elisa_1
CDL-M5251 Mouse Mouse CD27 Ligand / CD70 Protein, Mouse IgG2a Fc Tag, low endotoxin
CDL-M5251-structure
CDL-M5251-sds
CDL-M5251-elisa_1
TN7-H82F4 Human Biotinylated Human CD27 Ligand / CD70 Protein, Avitag™,Fc Tag
TN7-H82F4-structure
TN7-H82F4-sds
TN7-H82F4-elisa_1
TN7-H526x Human Human CD27 Ligand / CD70 Protein, Fc Tag
TN7-H526x-structure
TN7-H526x-sds
TN7-H526x-elisa_1

CD27 Ligand Part of Bioactivity data

CDL-C5244-ELISA
Cynomolgus CD27 Ligand, His Tag (active trimer) (MALS verified)Cynomolgus CD27 Ligand, His Tag (active trimer) (MALS verified) (Cat. No. CDL-C5244) ELISA bioactivity

Immobilized Cynomolgus CD27 Ligand, His Tag (Cat. No. CDL-C5244) at 2 μg/mL (100 μL/well) can bind Cynomolgus / Rhesus macaque CD27, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. CD7-C5259) with a linear range of 1-8 ng/mL (QC tested).

CDD-HF2D4-MALS-HPLC
FITC-Labeled Human CD27 Ligand, His,Flag Tag (Cat. No. ) MALS images

The purity of FITC-Labeled Human CD27 Ligand, His,Flag Tag (Cat. No. CDD-HF2D4) was more than 90% and the molecular weight of this protein is around 65-75 kDa verified by SEC-MALS.

Bioactivity-ELISA
FITC-Labeled Human CD27 Ligand, His,Flag TagFITC-Labeled Human CD27 Ligand, His,Flag Tag (Cat. No. CDD-HF2D4) ELISA bioactivity

Measured by its binding ability in a functional ELISA. Immobilized Anti-CD27 Ligand Antibody, Human IgG1 at 1 μg/mL (100 μL/well) can bind FITC-Labeled Human CD27 Ligand, His,Flag Tag (Cat. No. CDD-HF2D4) with a linear range of 0.039-0.156 μg/mL (QC tested).

CD27 Ligand Molecule Synonym Name

CD70,CD27LG,TNFSF7,TNFSF7G,CD27L

CD27 Ligand Molecule Background

Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.

CD27 Ligand References

CD27 Ligand Related Molecule

CD27 Ligand Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AMG-172 AMG-172 Phase Ⅰ Amgen Renal carcinoma Details
MDX-1411 MDX-1411 Phase Ⅰ Medarex Renal carcinoma Details
SGN-CD70A SGN-CD70A; SGN-70A; SGNCD-70A Phase Ⅰ Seattle Genetics Non-Hodgkin's lymphoma (NHL), Renal carcinoma Details
CTX-130 CTX-130 Phase Ⅰ CRISPR Therapeutics hematological malignancies, Solid tumours Details
Vorsetuzumab mafodotin SGN-75 Phase Ⅰ Seattle Genetics Non-Hodgkin's lymphoma (NHL), Renal carcinoma Details
Anti-CD70 CAR T cell therapy (Allogene Therapeutics) Preclinical Allogene Therapeutics Renal cell carcinoma, Non-Hodgkin's lymphoma (NHL) Details
Cusatuzumab ARGX-110; JNJ-4550 Phase Ⅱ arGEN-X, Janssen Myelodysplastic syndrome (MDS), Cutaneous T cell lymphoma (CTCL), hematological malignancies, Solid tumours, Acute myeloid Leukemia (AML) Details
Vorsetuzumab SGN-70,SGN70 Phase Ⅰ Seattle Genetics Plaque psoriasis, Autoimmune diseases, Inflammation, Cancer Details
MDX-1203 BMS-936561; MDX-1203 Phase Ⅰ Bristol-Myers Squibb Non-Hodgkin B-cell lymphomas, Renal carcinoma Details

This web search service is supported by Google Inc.

totop