There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > CD27 Ligand

CD27 Ligand

CD27 Ligand Molecule Information

Name:CD70 antigen
Target Synonym:CD27-L;Tumor necrosis factor ligand superfamily member 7;CD70;CD27L;CD27LG;TNFSF7;CD27 ligand
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Phase ?

CD27 Ligand Protein Product ListCompare or Buy

CD27 Ligand Molecule Synonym Name


CD27 Ligand Molecule Background

Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFN? production, on NK cells.

CD27 Ligand References

CD27 Ligand Related Molecule

CD27 Ligand Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AMG-172 AMG-172 Phase Ⅰ Amgen Renal carcinoma Details
MDX-1411 MDX-1411 Phase Ⅰ Medarex Renal carcinoma Details
SGN-CD70A SGN-CD70A; SGN-70A; SGNCD-70A Phase Ⅰ Seattle Genetics Non-Hodgkin's lymphoma (NHL), Renal carcinoma Details
Vorsetuzumab mafodotin SGN-75 Phase Ⅰ Seattle Genetics Non-Hodgkin's lymphoma (NHL), Renal carcinoma Details
Anti-CD70 CAR T cell therapy (Allogene Therapeutics) Preclinical Allogene Therapeutics Renal cell carcinoma, Non-Hodgkin's lymphoma (NHL) Details
Cusatuzumab ARGX-110; JNJ-4550 Phase Ⅱ arGEN-X, Janssen Myelodysplastic syndrome (MDS), Cutaneous T cell lymphoma (CTCL), hematological malignancies, Solid tumours, Acute myeloid Leukemia (AML) Details
Vorsetuzumab SGN-70,SGN70 Phase Ⅰ Seattle Genetics Plaque psoriasis, Autoimmune diseases, Inflammation, Cancer Details
MDX-1203 BMS-936561; MDX-1203 Phase Ⅰ Bristol-Myers Squibb Non-Hodgkin B-cell lymphomas, Renal carcinoma Details

This web search service is supported by Google Inc.