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CD27 Ligand

Brief Information

Name:CD70 antigen
Target Synonym:LPFS3,CD27L,Tumor necrosis factor ligand superfamily member 7,CD27LG,CD27-L,CD70,CD70 Molecule,TNFSF7,Tumor Necrosis Factor (Ligand) Superfamily, Member 7,Tumor Necrosis Factor Ligand 8A,Ki-24 Antigen,TNLG8A,CD27 Ligand,CD70 antigen,Surface Antigen CD70
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

CDL-H82D7-ELISA
Biotinylated Human CD27 Ligand, His,Avitag,Flag Tag (active trimer) (MALS verified)Biotinylated Human CD27 Ligand, His,Avitag,Flag Tag (active trimer) (MALS verified) (Cat. No. CDL-H82D7) ELISA bioactivity

Immobilized Human CD27, Fc Tag (Cat. No. CD7-H5254) at 2 μg/mL (100 μL/well) can bind Biotinylated Human CD27 Ligand, His,Avitag,Flag Tag (active trimer) (MALS verified) (Cat. No. CDL-H82D7) with a linear range of 0.1-4 ng/mL (QC tested).

CDD-HF2D4-MALS-HPLC
FITC-Labeled Human CD27 Ligand, His,Flag Tag (Cat. No. ) MALS images

The purity of FITC-Labeled Human CD27 Ligand, His,Flag Tag (Cat. No. CDD-HF2D4) was more than 85% and the molecular weight of this protein is around 65-75 kDa verified by SEC-MALS.

Bioactivity-ELISA
FITC-Labeled Human CD27 Ligand, His,Flag TagFITC-Labeled Human CD27 Ligand, His,Flag Tag (Cat. No. CDD-HF2D4) ELISA bioactivity

Immobilized Anti-CD27 Ligand Antibody, Human IgG1 at 1 μg/mL (100 μL/well) can bind FITC-Labeled Human CD27 Ligand, His,Flag Tag (Cat. No. CDD-HF2D4) with a linear range of 0.039-0.156 μg/mL (QC tested).

Synonym Name

CD70,CD27LG,TNFSF7,TNFSF7G,CD27L

Background

Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
CTX-130 CTX-130 Phase 1 Clinical Crispr Therapeutics Hematologic Neoplasms; Carcinoma, Renal Cell; Lymphoma, T-Cell Details
Cusatuzumab ARGX-110; JNJ-4550 Phase 2 Clinical Argen-X Hematologic Neoplasms; Neoplasms; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Leukemia, Myeloid, Acute; Lymphoma, T-Cell, Cutaneous Details
SEA-CD70 SEA-CD70 Phase 1 Clinical Seattle Genetics Inc Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details

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