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CD27 Ligand

CD27 Ligand Molecule Information

Name:CD70 antigen
Target Synonym:LPFS3,CD27L,Tumor necrosis factor ligand superfamily member 7,CD27LG,CD27-L,CD70,CD70 Molecule,TNFSF7,Tumor Necrosis Factor (Ligand) Superfamily, Member 7,Tumor Necrosis Factor Ligand 8A,Ki-24 Antigen,TNLG8A,CD27 Ligand,CD70 antigen,Surface Antigen CD70
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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CD27 Ligand Part of Bioactivity data

CDL-H82D7-ELISA
Biotinylated Human CD27 Ligand, His,Avitag,Flag Tag (active trimer) (MALS verified)Biotinylated Human CD27 Ligand, His,Avitag,Flag Tag (active trimer) (MALS verified) (Cat. No. CDL-H82D7) ELISA bioactivity

Immobilized Human CD27, Fc Tag (Cat. No. CD7-H5254) at 2 μg/mL (100 μL/well) can bind Biotinylated Human CD27 Ligand, His,Avitag,Flag Tag (active trimer) (MALS verified) (Cat. No. CDL-H82D7) with a linear range of 0.1-4 ng/mL (QC tested).

CDD-HF2D4-MALS-HPLC
FITC-Labeled Human CD27 Ligand, His,Flag Tag (Cat. No. ) MALS images

The purity of FITC-Labeled Human CD27 Ligand, His,Flag Tag (Cat. No. CDD-HF2D4) was more than 85% and the molecular weight of this protein is around 65-75 kDa verified by SEC-MALS.

Bioactivity-ELISA
FITC-Labeled Human CD27 Ligand, His,Flag TagFITC-Labeled Human CD27 Ligand, His,Flag Tag (Cat. No. CDD-HF2D4) ELISA bioactivity

Immobilized Anti-CD27 Ligand Antibody, Human IgG1 at 1 μg/mL (100 μL/well) can bind FITC-Labeled Human CD27 Ligand, His,Flag Tag (Cat. No. CDD-HF2D4) with a linear range of 0.039-0.156 μg/mL (QC tested).

CD27 Ligand Molecule Synonym Name

CD70,CD27LG,TNFSF7,TNFSF7G,CD27L

CD27 Ligand Molecule Background

Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.

CD27 Ligand References

CD27 Ligand Related Molecule

CD27 Ligand Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Cusatuzumab ARGX-110; JNJ-4550 Phase 2 Clinical Argen-X Hematologic Neoplasms; Neoplasms; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Leukemia, Myeloid, Acute; Lymphoma, T-Cell, Cutaneous Details
CTX-130 CTX-130 Phase 1 Clinical Crispr Therapeutics Hematologic Neoplasms; Carcinoma, Renal Cell; Lymphoma, T-Cell Details

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