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CD27 Ligand

CD27 Ligand Molecule Information

Name:CD70 antigen
Target Synonym:CD27-L?Tumor necrosis factor ligand superfamily member 7?CD70?CD27L?CD27LG?TNFSF7?CD27 ligand
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Phase ?

CD27 Ligand Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
CDL-H82Q9 Human Biotinylated Human CD27 Ligand / CD70 Protein, His Tag, Avi Tag (Avitag™)
CDL-H82Q9-structure
CDL-H82Q9-sds
CDL-H82Q9-elisa_1
CDL-M82Qb Mouse Biotinylated Mouse CD27 Ligand / CD70 Protein, His Tag, Avi Tag (Avitag™)
CDL-M82Qb-structure
CDL-M82Qb-sds
CDL-M82Qb-elisa_1
CDL-H5246 Human Human CD27 Ligand / CD70 Protein, His Tag
CDL-H5246-structure
CDL-H5246-sds
CDL-H5246-elisa_1
CDL-M5245 Mouse Mouse CD27 Ligand / CD70 Protein (active trimer) (HPLC-verified)
CDL-M5245-structure
CDL-M5245-sds
CDL-M5245-hplc
CDL-M5245-elisa_1
CDL-H525a Human Human CD27 Ligand / CD70 Protein, Mouse IgG2a Fc Tag, low endotoxin
CDL-H525a-structure
CDL-H525a-sds
CDL-H525a-elisa_1
CDL-M5251 Mouse Mouse CD27 Ligand / CD70 Protein, Mouse IgG2a Fc Tag, low endotoxin
CDL-M5251-structure
CDL-M5251-sds
CDL-M5251-elisa_1
TN7-H82F4 Human Biotinylated Human CD27 Ligand / CD70 Protein, Fc Tag, Avi Tag (Avitag™)
TN7-H82F4-structure
TN7-H82F4-sds
TN7-H82F4-elisa_1
TN7-H526x Human Human CD27 Ligand / CD70 Protein, Fc Tag
TN7-H526x-structure
TN7-H526x-sds
TN7-H526x-elisa_1

CD27 Ligand Molecule Synonym Name

CD70,CD27LG,TNFSF7,TNFSF7G,CD27L

CD27 Ligand Molecule Background

Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFN¦Ã production, on NK cells.

CD27 Ligand References

CD27 Ligand Related Molecule

CD27 Ligand Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AMG-172 AMG-172 Phase Ⅰ Amgen Renal carcinoma Details
MDX-1411 MDX-1411 Phase Ⅰ Medarex Renal carcinoma Details
SGN-CD70A SGN-CD70A; SGN-70A; SGNCD-70A Phase Ⅰ Seattle Genetics Non-Hodgkin's lymphoma (NHL), Renal carcinoma Details
Vorsetuzumab mafodotin SGN-75 Phase Ⅰ Seattle Genetics Non-Hodgkin's lymphoma (NHL), Renal carcinoma Details
ARGX-110 ARGX-110 Phase Ⅱ arGEN-X Nasopharyngeal cancer, hematological malignancies, Solid tumours, Acute myeloid Leukemia (AML) Details
Vorsetuzumab SGN-70,SGN70 Phase Ⅰ Seattle Genetics Plaque psoriasis, Autoimmune diseases, Inflammation, Cancer Details
MDX-1203 MDX-1203; BMS-936561 Phase Ⅰ Bristol-Myers Squibb Non-Hodgkin B-cell lymphomas, Renal carcinoma Details

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