FOLR1

FOLR1 Molecule Information

FOLR1 Protein Product ListCompare or Buy

Cat. No.	Species	Product Description	Structure	Purity	Feature
FO1-H82F9	Human	Biotinylated Human FOLR1 Protein, Fc Tag, Avi Tag (Avitag™)
FO1-H5253	Human	Human FOLR1 Protein, Fc Tag
FO1-H82E2	Human	Biotinylated Human FOLR1 Protein, His Tag, Avi Tag (Avitag™)
FO1-C52H8	Cynomolgus / Rhesus macaque	Cynomolgus / Rhesus macaque FOLR1 Protein, His tag
FO1-M82E9	Mouse	Biotinylated Mouse FOLR1 Protein, Avi Tag (Avitag™)
FO1-M5225	Mouse	Mouse FOLR1 Protein
FO1-H528b	Human	Human FOLR1 Protein, Strep Tag
FO1-H5229	Human	Human FOLR1 Protein, His Tag

r several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.