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FOLR1

FOLR1 Molecule Information

Name:Folate receptor alpha
Target Synonym:FOLR1?Folate receptor 1?FR-alpha?FOLR?Adult folate-binding protein?Folate receptor, adult?Folate receptor alpha?KB cells FBP?Ovarian tumor-associated antigen MOv18?FBP
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:15
Lastest Research Phase:Phase ?

FOLR1 Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
FO1-H82F9 Human Biotinylated Human FOLR1 Protein, Fc Tag, Avi Tag (Avitag™)
FO1-H82F9-structure
FO1-H82F9-sds
FO1-H82F9-elisa_1
FO1-H5253 Human Human FOLR1 Protein, Fc Tag
FO1-H5253-structure
FO1-H5253-sds
FO1-H5253-elisa_1
FO1-H82E2 Human Biotinylated Human FOLR1 Protein, His Tag, Avi Tag (Avitag™)
FO1-H82E2-structure
FO1-H82E2-sds
FO1-H82E2-elisa_1
FO1-C52H8 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque FOLR1 Protein, His tag
FO1-C52H8-structure
FO1-C52H8-sds
FO1-C52H8-elisa_1
FO1-M82E9 Mouse Biotinylated Mouse FOLR1 Protein, Avi Tag (Avitag™)
FO1-M82E9-structure
FO1-M82E9-sds
FO1-M82E9-elisa_1
FO1-M5225 Mouse Mouse FOLR1 Protein
FO1-M5225-structure
FO1-M5225-sds
FO1-M5225-elisa_1
FO1-H528b Human Human FOLR1 Protein, Strep Tag
FO1-H528b-structure
FO1-H528b-sds
FO1-H5229 Human Human FOLR1 Protein, His Tag
FO1-H5229-structure
FO1-H5229-sds
FO1-H5229-elisa_1

r several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.

FOLR1 References

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