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Brief Information

Name:Folate receptor alpha
Target Synonym:FRalpha,KB cells FBP,Adult folate-binding protein,Folate receptor 1,Folate receptor alpha,FR-alpha,FOLR1,Ovarian Tumor-Associated Antigen MOv18,Folate Receptor 1 (Adult),Folate Receptor, Adult,FOLR,FBP,Folate Binding Protein,FRα
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:11
Lastest Research Phase:Approved


Project item Indications Research phase Cooperation demands
BSW202201 Ovarian cancer Preclinical sequence authorization or project transfer

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Part of Bioactivity data

FO1-HA2H8-Cell-based assay

5e5 of anti-FOLR1 CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of APC-Labeled Human FOLR1 Protein, His Tag (Cat. No. FO1-HA2H8) and negative control protein respectively (Fig. C and B), and non-transfected 293 cells were used as a control (Fig. A). APC signal was used to evaluate the binding activity (QC tested).


Immobilized Folic Acid-BSA Conjugate at 5 μg/mL (100 μL/well) can bind Human FOLR1, His Tag (Cat. No. FO1-H52H1) with a linear range of 5-78 ng/mL (QC tested).

FOLR1 MALS images

The purity of FITC-Labeled Human FOLR1, His Tag (Cat. No. FO1-HF2H8) is more than 90% and the molecular weight of this protein is around 40-50 kDa verified by SEC-MALS.

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Synonym Name



Folate Receptor 1 (FOLR1) is also known as Folate receptor alpha, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Folinic Acid FTHF Approved Anemia; Autism Spectrum Disorder; Down Syndrome; Rectal Neoplasms; Diarrhea; Vitamin B 12 Deficiency; Colorectal Neoplasms Details
Pafolacianine Sodium Pteroyl-L-Tyr-S0456; OTL-38; EC-17; OTL-0038 Approved On Target Laboratories Inc Cytalux United States Ovarian Neoplasms On Target Laboratories Inc 2021-11-29 Ovarian Neoplasms; Inflammatory Bowel Diseases; Arthritis, Rheumatoid; Neoplasms; Breast Neoplasms; Pituitary Neoplasms; Lung Neoplasms Details
Mirvetuximab soravtansine M9346-Asulfo-SPDB-DM4; IMGN-853 Approved Immunogen Inc United States Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms; Peritoneal Neoplasms Immunogen Inc 2022-11-14 Ovarian Neoplasms; Solid tumours; Cystadenoma, Serous; Carcinoma, Ovarian Epithelial; Neoplasms; Triple Negative Breast Neoplasms; Breast Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Endometrial Neoplasms; Uterine Neoplasms; Carcinosarcoma; Adenocarcinoma Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Noscapine-folate conjugate Phase 1 Clinical Emory University Hematologic Neoplasms; Inflammation Details
4S-CAR-FRa 4S-CAR-FRa Phase 2 Clinical Shenzhen Geno-Immune Medical Institute Carcinoma, Transitional Cell; Urinary Bladder Neoplasms Details
MOv19-BBz CAR-T cells Therapy University Of Pennsylvania Details
Epofolate BMS-753493 Bristol-Myers Squibb Company, Novartis Pharma Ag Details
BAT-8006 BAT8006; BAT-8006 Phase 1 Clinical Bio-Thera Solutions Ltd Solid tumours; Neoplasms Details
ITIL-306 ITIL-306 Phase 1 Clinical Instil Bio Inc Solid tumours; Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Genital Neoplasms, Female; Carcinoma, Non-Small-Cell Lung Details
ELU-001 ELU-001 Phase 2 Clinical Elucida Oncology Inc Cholangiocarcinoma; Neoplasm Metastasis; Carcinoma, Endometrioid; Adenocarcinoma; Endometrial Neoplasms; Fallopian Tube Neoplasms; Leukemia, Myeloid, Acute; Colorectal Neoplasms; Bile Duct Neoplasms; Peritoneal Neoplasms; Breast Neoplasms; Biliary Tract Neoplasms; Klatskin Tumor; Colonic Neoplasms; Triple Negative Breast Neoplasms; Carcinoma, Ovarian Epithelial; Ovarian Diseases; Stomach Neoplasms; Rectal Neoplasms; Esophageal Neoplasms; Ovarian Neoplasms; Uterine Diseases Details
PRO-1184 PRO-1184 Phase 2 Clinical ProfoundBio (Suzhou) Co Ltd Ovarian Neoplasms; Solid tumours; Triple Negative Breast Neoplasms; Mesothelioma; Breast Neoplasms; Peritoneal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Farletuzumab ecteribulin MORAb-202 Phase 2 Clinical Eisai Co Ltd, Morphotek Inc, Bristol-Myers Squibb Company Ovarian Neoplasms; Solid tumours; Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Luveltamab tazevibulin SP-7219; DBCO-Alexa647-conjugated SP7219; STRO-002; SP-7675; SP-7676 Phase 1 Clinical Sutro Biopharma Inc Ovarian Neoplasms; Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Endometrioid Details
MOv-18 IgE MOv-18 IgE; MOv18; MOv-18 Phase 1 Clinical King'S College London, Cancer Research UK Ovarian Neoplasms; Neoplasms Details
Arfolitixorin ISO-901; 6R-MTHF Phase 3 Clinical Isofol Medical Ab Rectal Neoplasms; Colonic Neoplasms; Osteosarcoma; Colorectal Neoplasms Details
CBP-1008 CBP-1008 Phase 2 Clinical Coherent Biopharma Suzhou Co Ltd Ovarian Neoplasms; Solid tumours; Carcinoma, Ovarian Epithelial; Breast Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Squamous Cell Details

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