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| Cat. No. | Species | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|
| CEA-C202 | Human | ClinMax™ Human PCSK9 ELISA Kit | |||
| PC9-H52H7 | Human | Human PCSK9 Protein, His Tag |  |
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| EP-103 | Human | PCSK9 [Biotinylated] : LDL R Inhibitor Screening ELISA Assay Pair | |||
| PC9-H5256 | Human | Human PCSK9 Protein, Fc Tag |  |
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| PC9-H52E4 | Hamster | Hamster PCSK9 Protein, His Tag |  |
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| PC9-C5223 | Cynomolgus | Cynomolgus PCSK9 Protein, His Tag |  |
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| PC9-M82E1 | Mouse | Biotinylated Mouse PCSK9 Protein, Avitag™,His Tag |  |
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| PCY-H5225 | Human | Human PCSK9 (D374Y) Protein, His Tag (MALS verified) |  |
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| PC9-C52H2 | Rhesus macaque | Rhesus macaque PCSK9 Protein, His Tag |  |
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| PC9-R52H4 | Rat | Rat PCSK9 Protein, His Tag |  |
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| PCY-H82E7 | Human | Biotinylated Human PCSK9 (D374Y) Protein, Avitag™,His Tag |  |
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| PC9-H82E7 | Human | Biotinylated Human PCSK9 Protein, Avitag™,His Tag (MALS verified) |  |
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| PC9-M5228 | Mouse | Mouse PCSK9 Protein, His Tag |  |
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| PC9-H5223 | Human | Human PCSK9 Protein, His Tag (MALS verified) |  |
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FACS analysis shows that Human PCSK9 (D374Y), His Tag (Cat. No. PCY-H5225) inhibits LDL uptake in HepG2 cells. The EC50 for this effect is 0.0689-0.3049 μg/mL.
FACS analysis shows that the effect of Human PCSK9 (D374Y), His Tag (Cat. No. PCY-H5225) inhibiting LDL uptake in HepG2 cells was neutralized by Anti-Human PCSK9 antibody. The concentration of PCSK9 used is 5 μg/mL. The EC50 for Anti-Human PCSK9 antibody is 6.816-12.67 μg/mL.
Loaded Human PCSK9, Fc Tag (Cat. No. PC9-H5256) on Protein A Biosensor, can bind Human LDL R, His Tag (Cat. No. LDR-H5224) with an affinity constant of 12.7 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
| Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indications | Clinical Trials |
|---|---|---|---|---|---|---|---|---|---|---|
| Inclisiran sodium | KJX-839; ALN-60212; PCSK9si; ALN-PCSsc; KJX839 | Approved | Alnylam Pharmaceuticals Inc | Leqvio, 乐可为 | EU | Dyslipidemias; Hypercholesterolemia | Novartis Europharm Ltd | 2020-12-09 | Hypolipoproteinemias; Diabetes Mellitus; Hyperlipidemias; Hyperlipoproteinemia Type II; Cardiovascular Diseases; Dyslipidemias; Heterozygous familial hypercholesterolemia; Coronary Disease; Acute Coronary Syndrome; Stroke; Plaque, Atherosclerotic; Coronary Artery Disease; Hypercholesterolemia; Renal Insufficiency; Myocardial Infarction; Diabetes Mellitus, Type 2; Carotid Artery Diseases; Atherosclerosis; Homozygous familial hypercholesterolemia | Details |
| Ongericimab | JS-002 | Approved | Shanghai Junshi Biosciences Co Ltd | 君适达 | Mainland China | Hypercholesterolemia; Dyslipidemias | Shanghai Junshi Biosciences Co Ltd | 2024-10-09 | Hypertriglyceridemia; Atherosclerosis; Hypercholesterolemia; Neoplasms; Heterozygous familial hypercholesterolemia; Dyslipidemias; Hyperlipidemias; Hyperlipidemia, Familial Combined | Details |
| Ebronucimab | AK-102 | Approved | Zhongshan Akeso Biopharma Co Ltd, Yabao Us Pharmaceutical Co Ltd | 伊喜宁 | Mainland China | Hypercholesterolemia; Dyslipidemias | Kang Rong Dongfang (Guangdong) Pharmaceutical Co Ltd | 2024-09-26 | Homozygous familial hypercholesterolemia; Hypercholesterolemia; Dyslipidemias; Heterozygous familial hypercholesterolemia; Hyperlipidemias; Hyperlipidemia, Familial Combined; Hyperlipoproteinemia Type II | Details |
| Recaticimab | SHR-1209 | Approved | Jiangsu Hengrui Medicine Co Ltd | 艾心安 | Mainland China | Hypercholesterolemia; Dyslipidemias | Guangdong Hengrui Pharmaceutical Co Ltd | 2025-01-08 | Hypercholesterolemia; Dyslipidemias; Hyperlipidemias; Hyperlipidemia, Familial Combined; Hyperlipoproteinemia Type II | Details |
| Evolocumab | AMG-145 | Approved | Amgen Inc, Astellas Pharma Inc | 瑞百安, Repatha | EU | Dyslipidemias; Hypercholesterolemia | Amgen Europe Bv | 2015-07-17 | Stroke; Heart Failure, Systolic; Aortic Aneurysm, Abdominal; Diabetes Mellitus; Hyperlipidemias; Hyperlipoproteinemia Type II; Glioma; Rejection in heart transplantation; Cardiovascular Diseases; Coronary Disease; Dyslipidemias; Heterozygous familial hypercholesterolemia; HIV Infections; Acute Coronary Syndrome; Glioblastoma; Coronary Artery Disease; Sepsis; Hypercholesterolemia; ST Elevation Myocardial Infarction; Atherosclerosis; Diabetes Mellitus, Type 2; Myocardial Infarction; Homozygous familial hypercholesterolemia | Details |
| Tafolecimab | IBI-306 | Approved | Innovent Biologics(Suzhou) Co Ltd | 信必乐 | Mainland China | Dyslipidemias; Hypercholesterolemia | Innovent Biologics(Suzhou) Co Ltd | 2023-08-15 | Homozygous familial hypercholesterolemia; Hypercholesterolemia; Heterozygous familial hypercholesterolemia; Dyslipidemias | Details |
| Alirocumab | 316P; REGN-727; SAR-236553 | Approved | Sanofi, Regeneron Pharmaceuticals Inc | 波立达, Praluent | United States | Hypercholesterolemia | Regeneron Pharmaceuticals Inc | 2015-07-24 | Hemorrhage; Hyperlipidemias; Drinking Behavior; Cardiovascular Diseases; Ischemic Stroke; Vascular Diseases; Coronary Disease; Heterozygous familial hypercholesterolemia; Dyslipidemias; Angina Pectoris; Intracranial Arteriosclerosis; Stroke; Shock, Septic; Acute Coronary Syndrome; Hypercholesterolemia; Sepsis; Myocardial Infarction; Diabetes Mellitus, Type 2; ST Elevation Myocardial Infarction; Atherosclerosis; Homozygous familial hypercholesterolemia; Plaque, Atherosclerotic; Liver Diseases, Alcoholic; HIV Infections | Details |
| Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
|---|---|---|---|---|---|
| Recombinant human anti-PCSK9 monoclonal antibody (Salubris) | SAL003 | Phase 3 Clinical | Shenzhen Salubris Pharmaceuticals Co Ltd | Hypercholesterolemia; Dyslipidemias; Hyperlipidemia, Familial Combined; Hyperlipidemias | Details |
| AZD-0780 | AZD0780; AZD-0780 | Phase 3 Clinical | Dogma Therapeutics | Plaque, Atherosclerotic; Renal Insufficiency; Dyslipidemias; Hepatic Insufficiency; Cardiovascular Diseases | Details |
| Enlicitide Decanoate | MK-0616 | Phase 3 Clinical | Merck Sharp & Dohme Corp | Atherosclerosis; Renal Insufficiency; Hypercholesterolemia; Kidney Diseases; Cardiovascular Diseases; Hepatic Insufficiency; Arteriosclerosis; Hyperlipoproteinemia Type II | Details |
| AZD-8233 | AZD-8233; IONIS-AZ4-2.5-LRx; ION-449 | Phase 2 Clinical | Ionis Pharmaceuticals Inc | Hypercholesterolemia; Dyslipidemias; Hyperlipidemias; Kidney Failure, Chronic | Details |
| CiVi-007 | CiVi-007; LNA-PCSK -9; LNA-PCSK9-GalNac | Phase 2 Clinical | F. Hoffmann-La Roche Ltd | Hypercholesterolemia | Details |
| CVI-LM-001 | CVI-LM-001; CVI-LM001; C-8304 | Phase 2 Clinical | Xiwei'Ai Medicine Technology (Shanghai) Co Ltd | Hypercholesterolemia; Hyperlipidemias | Details |
| ATX-304 | O-304; ATX-304; O-304X | Phase 2 Clinical | Betagenon Ab | Mitochondrial Diseases; Diabetes Mellitus, Type 2; Peripheral Arterial Disease | Details |
| MIL-86 | MIL-86 | Phase 2 Clinical | Beijing Mabworks Biotech Co Ltd | Hypercholesterolemia; Heterozygous familial hypercholesterolemia; Cardiovascular Diseases; Hyperlipidemias; Hyperlipoproteinemia Type II | Details |
| NNC0385-0434 | NNC0385-0434; NN-6435; NNC 0385 0434 | Phase 2 Clinical | Novo Nordisk A/S | Plaque, Atherosclerotic; Diabetes Mellitus, Type 2; Hypercholesterolemia; Cardiovascular Diseases; Arteriosclerosis; Renal Insufficiency, Chronic | Details |
| PCSK9 Inhibitors therapy(Guangdong Provincial People'S Hospital) | Phase 2 Clinical | Guangdong Provincial People'S Hospital | Colorectal Neoplasms | Details | |
| SYH-2053 | SYH2053; SYH-2053 | Phase 2 Clinical | CSPC Pharmaceutical Group Ltd | Hypercholesterolemia; Dyslipidemias; Hyperlipidemia, Familial Combined; Hyperlipidemias | Details |
| RBD-7022 | RBD7022; RBD-7022; SR043; SR-043; QLC-7401 | Phase 2 Clinical | Suzhou Ribo Life Science Co Ltd | Hypercholesterolemia; Hyperlipidemias; Hyperlipidemia, Familial Combined | Details |
| Recombinant human anti-PCSK9 monoclonal antibody (Tasly Pharm) | B1655; B-1655 | Phase 1 Clinical | Tianjin Tasly Pharmaceutical Co Ltd | Hypercholesterolemia | Details |
| DC-371739 | JYP-0739; DC-371739 | Phase 1 Clinical | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Hypercholesterolemia; Dyslipidemias; Hyperlipidemias | Details |
| Anti-PCSK9 monoclonal antibody (Biocad) | Phase 1 Clinical | BIOCAD JSC | Cardiovascular Diseases | Details | |
| ATH-04 | ATH-04; Affitope AT04A | Phase 1 Clinical | Affiris Ag | Atherosclerosis | Details |
| VERVE-101 | VERVE-101 | Phase 1 Clinical | Broad Institute, Harvard University | Plaque, Atherosclerotic; Hypercholesterolemia; Heterozygous familial hypercholesterolemia | Details |
| SAL-092 | SAL092; SAL-092 | Phase 1 Clinical | Shenzhen Salubris Pharmaceuticals Co Ltd | Hypercholesterolemia; Dyslipidemias | Details |
| VERVE-102 | VERVE-102 | Phase 1 Clinical | Verve Therapeutics Inc | Atherosclerosis; Heterozygous familial hypercholesterolemia; Coronary Disease | Details |
| SGB-3403 | SGB-3403 | Phase 1 Clinical | Suzhou Sanegene Biopharmaceuticals Ltd | Atherosclerosis; Hypercholesterolemia; Heterozygous familial hypercholesterolemia; Cardiovascular Diseases; Hyperlipidemias | Details |
| RN-0191 | RN0191 | Phase 1 Clinical | Darui Biomedical Technology (Shanghai) Co Ltd | Atherosclerosis; Hypercholesterolemia; Dyslipidemias | Details |
| RP-910 | RP910; RP-910 | Phase 1 Clinical | Runjia (Shanghai) Pharmaceutical Technology Co Ltd | Metabolic Diseases; Hyperlipidemias | Details |
| YOLT-101 | YOLT-101 | Phase 1 Clinical | Yoltech Therapeutics Co Ltd | Hyperlipoproteinemia Type II | Details |
| JX-7002 | JX7002; JX-7002 | Phase 1 Clinical | Zhejiang Jingxin Pharmaceutical Co Ltd | Hypercholesterolemia; Hyperlipidemias | Details |
| NN-6434 | NN-6434 | Phase 1 Clinical | Novo Nordisk A/S | Details | |
| PCSK9 modulator (Genekey Biotech) | Phase 1 Clinical | Shenzhen Salubris Pharmaceuticals Co Ltd | Metabolic Diseases; Inflammation | Details |
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