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Syndecan-1

Syndecan-1 Molecule Information

Name:Syndecan-1
Target Synonym:SYND1;CD138;SDC;SDC1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase ?

Syndecan-1 Protein Product ListCompare or Buy

Syndecan-1 Part of Bioactivity data

SY1-H5253-ELISA
Human Syndecan-1, Fc TagHuman Syndecan-1, Fc Tag (Cat. No. SY1-H5253) ELISA bioactivity

Immobilized Human Syndecan-1, Fc Tag (Cat. No. SY1-H5253) at 1 μg/mL (100 μL/well) can bind Anti-Syndecan-1 antibody, Mouse IgG1 with a linear range of 0.1-3 ng/mL (QC tested).

SY1-H5225-MALS-HPLC
Human Syndecan-1, His Tag (Cat. No. ) MALS images

The purity of Human Syndecan-1, His Tag (Cat. No.SY1-H5225) was more than 95% and the molecular weight of this protein is around 35-45 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human Syndecan-1, His TagHuman Syndecan-1, His Tag (Cat. No. SY1-H5225) ELISA bioactivity

Immobilized Human Syndecan-1, His Tag (Cat. No. SY1-H5225) at 1 μg/mL (100 μL/well) can bind Anti-Syndecan-1 antibody, Mouse IgG1 (Cat. No. Anti-Syndecan-1 antibody) with a linear range of 0.1-3 ng/mL (QC tested).

Syndecan-1 Molecule Synonym Name

SDC1,Syndecan-1,CD138,SYND1,SDC

Syndecan-1 Molecule Background

Syndecan-1 (SYND1 or SDC1) is also known as CD antigen CD138, is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 / SDC1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. It is a useful marker for plasma cells, but only if the cells tested are already known to be derived from blood.

Syndecan-1 References

Syndecan-1 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ATLCAR.CD138 (UNC Lineberger Comprehensive Cancer Center) Phase Ⅰ UNC Lineberger Comprehensive Cancer Center Multiple myeloma (MM), Immunological disorders Details
CART-138 (Chinese PLA General Hospital) Phase Ⅱ General Hospital of the People's Liberation Army Multiple myeloma (MM) Details
Indatuximab ravtansine BT-062; nBT-062 Phase Ⅱ Biotest Breast cancer, Multiple myeloma (MM), Bladder cancer Details

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