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Syndecan-1 Molecule Information

Target Synonym:SYND1;CD138;SDC;SDC1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase ?

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Cat. No. Species Product Description Structure Purity Feature
SD1-H5228 Human Human Syndecan-1 Protein, His Tag

Syndecan-1 Molecule Synonym Name


Syndecan-1 Molecule Background

Syndecan-1 (SYND1 or SDC1) is also known as CD antigen CD138, is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 / SDC1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. It is a useful marker for plasma cells, but only if the cells tested are already known to be derived from blood.

Syndecan-1 References

Syndecan-1 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ATLCAR.CD138 (UNC Lineberger Comprehensive Cancer Center) Phase Ⅰ UNC Lineberger Comprehensive Cancer Center Multiple myeloma (MM), Immunological disorders Details
CART-138 (Chinese PLA General Hospital) Phase Ⅱ General Hospital of the People's Liberation Army Multiple myeloma (MM) Details
Indatuximab ravtansine BT-062; nBT-062 Phase Ⅱ Biotest Breast cancer, Multiple myeloma (MM), Bladder cancer Details

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