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Your Position: Home > Syndecan-1

Syndecan-1

Brief Information

Name:Syndecan-1
Target Synonym:Syndecan Proteoglycan 1,CD138 Antigen,SYND1,SDC,Heparan Sulfate Proteoglycan Fibroblast Growth Factor Receptor,Syndecan,CD138,Syndecan-1,SDC1,Syndecan 1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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Cat. No. Species Product Description Structure Purity Feature
SY1-HA2H9 Human APC-Labeled Human Syndecan-1 Protein, His Tag (Site-specific conjugation)
SY1-H5225 Human Human Syndecan-1 Protein, His Tag
SY1-H5225-structure
SY1-H5225-sds
SY1-H5253 Human Human Syndecan-1 Protein, Fc Tag
SY1-H5253-structure
SY1-H5253-sds
SD1-HF228 Human FITC-Labeled Human Syndecan-1 Protein, His Tag
SD1-HF228-structure
SD1-HF228-sds
SY1-H82F3 Human Biotinylated Human Syndecan-1 Protein, Fc,Avitag™
SY1-H82F3-structure
SY1-H82F3-sds
SY1-H82E2 Human Biotinylated Human Syndecan-1 Protein, His,Avitag™
SY1-H82E2-structure
SY1-H82E2-sds
ACRO Quality

Part of Bioactivity data

SY1-HA2H9-Cell-based assay
Syndecan-1 FACS

5e5 of anti-Syndecan-1 CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of APC-Labeled Human Syndecan-1 Protein, His Tag (Cat. No. SY1-HA2H9) and negative control protein respectively. APC signal was used to evaluate the binding activity (QC tested).

Protocol
SY1-H5225-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

2e5 of anti-Syndecan-1 CAR-293 cells were stained with 100 μL of 3 μg/mL of Human Syndecan-1, His Tag (Cat. No. SY1-H5225) and negative control protein respectively, washed and then followed by PE anti-His Tag antibody and analyzed with FACS (Routinely tested).

Protocol
SY1-H5253-ELISA
Syndecan-1 ELISA

Immobilized Human Syndecan-1, Fc Tag (Cat. No. SY1-H5253) at 1 μg/mL (100 μL/well) can bind Anti-Syndecan-1 antibody, Mouse IgG1 with a linear range of 0.1-3 ng/mL (QC tested).

Protocol
SY1-H5225-ELISA
Human Syndecan-1, His TagHuman Syndecan-1, His Tag (Cat. No. SY1-H5225) ELISA bioactivity

Immobilized Human Syndecan-1, His Tag (Cat. No. SY1-H5225) at 1 μg/mL (100 μL/well) can bind Anti-Syndecan-1 antibody, Mouse IgG1 with a linear range of 0.1-3 ng/mL (QC tested).

Protocol

Synonym Name

SDC1,Syndecan-1,CD138,SYND1,SDC

Background

Syndecan-1 (SYND1 or SDC1) is also known as CD antigen CD138, is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 / SDC1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. It is a useful marker for plasma cells, but only if the cells tested are already known to be derived from blood.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ATLCAR.CD138 (UNC Lineberger Comprehensive Cancer Center) Phase 1 Clinical Unc Lineberger Comprehensive Cancer Center Immune System Diseases; Multiple Myeloma Details

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