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Syndecan-1

Brief Information

Name:Syndecan-1
Target Synonym:SDC1,Syndecan 1,Syndecan Proteoglycan 1,CD138 Antigen,SYND1,SDC,Heparan Sulfate Proteoglycan Fibroblast Growth Factor Receptor,Syndecan,CD138,Syndecan-1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

SY1-H5225-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

2e5 of anti-Syndecan-1 CAR-293 cells were stained with 100 μL of 3 μg/mL of Human Syndecan-1, His Tag (Cat. No. SY1-H5225) and negative control protein respectively, washed and then followed by PE anti-His Tag antibody and analyzed with FACS (Routinely tested).

SY1-H5253-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

2e5 of anti-Syndecan-1 CAR-293 cells were stained with 100 μL of 0.3 μg/mL of Human Syndecan-1, Fc Tag (Cat. No. SY1-H5253) and negative control protein respectively, washed and then followed by PE anti-human IgG Fc antibody and analyzed with FACS (Routinely tested).

SY1-H5253-ELISA
Human Syndecan-1, Fc TagHuman Syndecan-1, Fc Tag (Cat. No. SY1-H5253) ELISA bioactivity

Immobilized Human Syndecan-1, Fc Tag (Cat. No. SY1-H5253) at 1 μg/mL (100 μL/well) can bind Anti-Syndecan-1 antibody, Mouse IgG1 with a linear range of 0.1-3 ng/mL (QC tested).

SY1-H5225-ELISA
Human Syndecan-1, His TagHuman Syndecan-1, His Tag (Cat. No. SY1-H5225) ELISA bioactivity

Immobilized Human Syndecan-1, His Tag (Cat. No. SY1-H5225) at 1 μg/mL (100 μL/well) can bind Anti-Syndecan-1 antibody, Mouse IgG1 (Cat. No. Anti-Syndecan-1 antibody) with a linear range of 0.1-3 ng/mL (QC tested).

Synonym Name

SDC1,Syndecan-1,CD138,SYND1,SDC

Background

Syndecan-1 (SYND1 or SDC1) is also known as CD antigen CD138, is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 / SDC1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. It is a useful marker for plasma cells, but only if the cells tested are already known to be derived from blood.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ATLCAR.CD138 (UNC Lineberger Comprehensive Cancer Center) Phase 1 Clinical Unc Lineberger Comprehensive Cancer Center Multiple Myeloma Details
Indatuximab ravtansine BT-062; nBT-062 Phase 2 Clinical Biotest Pharma Gmbh Multiple Myeloma; Urinary Bladder Neoplasms; Breast Neoplasms Details
CART-138 (Chinese PLA General Hospital) Phase 2 Clinical People'S Liberation Army General Hospital Military Service Multiple Myeloma Details

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