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SIRP alpha

SIRP alpha Part of Bioactivity data

SIA-HP252-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

Flow Cytometry assay shows that PE-Labeled Human SIRP alpha, Fc Tag (recommended for neutralizing assay) (Cat. No. SIA-HP252) can bind to 293T cells overexpressing human CD47. 1 μl stock solution per million cells (QC tested).

SIA-HP252-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

FACS analysis shows that the binding of PE-Labeled Human SIRP alpha, Fc Tag (recommended for neutralizing assay) (Cat. No. SIA-HP252) to 293T overexpressing CD47 was inhibited by increasing concentration of neutralizing anti-human CD47 antibody. The IC50 is 0.37 μg/ml (QC tested).

SIA-H5225-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human CD47, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. CD7-H52A5) on Protein A Biosensor, can bind Human SIRP alpha, His Tag (HPLC-verified) (Cat. No. SIA-H5225) with an affinity constant of 1.1 μM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

SIA-H5225-BLI
Human_FcRn_Heterodimer_Protein_Bli

Immobilized Human CD47, Fc Tag (HPLC-verified) (Cat. No. CD7-H5256) on AHC Biosensor, can bind Human SIRP alpha, His Tag (HPLC-verified) (Cat. No. SIA-H5225) with an affinity constant of 0.72 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

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SIRP alpha Molecule Synonym Name

SHPS1,SIRPA,CD172A,BIT,MFR,MYD1,P84,PTPNS1

SIRP alpha Molecule Background

Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

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