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SIRP alpha

Brief Information

Name:Signal-regulatory protein alpha
Target Synonym:SHPS-1,Macrophage fusion receptor,Brain Ig-like molecule with tyrosine-based activation motifs,MFR,Signal-regulatory protein alpha-1,Signal-regulatory protein alpha-2,CD172a,MyD-1 antigen,Sirp-alpha-3,MYD1,SIRPA,Signal Regulatory Protein Alpha,CD172 Antig
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Approved

Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
SIA-C82E2 Cynomolgus Biotinylated Cynomolgus SIRP alpha / CD172a Protein, His,Avitag™ (MALS verified)
SIA-C82E2-structure
SIA-C82E2-sds
SIA-C82E2-elisa_1
SIA-M82E2 Mouse Biotinylated Mouse SIRP alpha / CD172a Protein, His,Avitag™ (MALS verified)
SIA-M82E2-structure
SIA-M82E2-sds
SIA-M82E2-elisa_1
SIA-H82A3 Human Biotinylated Human SIRP alpha / CD172a Protein, Mouse IgG2a Fc,Avitag™ (MALS verified)
SIA-H82A3-structure
SIA-H82A3-sds
SIA-H82A3-elisa_1
SIA-HP252 Human PE-Labeled Human SIRP alpha / CD172a Protein, Fc Tag (recommended for neutralizing assay)
SIA-HP252-structure
SIA-H82E0 Human Biotinylated Human SIRP alpha / CD172a Protein, His,Avitag™ (MALS verified)
SIA-H82E0-structure
SIA-H82E0-sds
SIA-H82E0-hplc
SIA-H82E0-elisa_1
SIA-M52H4 Mouse Mouse SIRP alpha / CD172a Protein, His Tag
SIA-M52H4-structure
SIA-M52H4-sds
SIA-M52H4-elisa_1
SIA-M5258 Mouse Mouse SIRP alpha / CD172a Protein, Fc Tag
SIA-M5258-structure
SIA-M5258-sds
SIA-M5258-elisa_1
SIA-C5254 Cynomolgus Cynomolgus SIRP alpha / CD172a Protein, Fc Tag
SIA-C5254-structure
SIA-C5254-sds
SIA-C5254-elisa_1
SIA-C52H7 Cynomolgus Cynomolgus SIRP alpha / CD172a Protein, His Tag
SIA-C52H7-structure
SIA-C52H7-sds
SIA-C52H7-elisa_1
SIA-M5252 Mouse Mouse SIRP alpha / CD172a Protein, Mouse IgG2a Fc Tag, low endotoxin
SIA-M5252-structure
SIA-M5252-sds
SIA-M5252-elisa_1
CDA-H82F2 Human Biotinylated Human SIRP alpha / CD172a Protein, Fc,Avitag™ (MALS verified)
CDA-H82F2-structure
CDA-H82F2-sds
CDA-H82F2-elisa_1
SIA-H5225 Human Human SIRP alpha / CD172a Protein, His Tag (MALS verified)
SIA-H5225-structure
SIA-H5225-sds
SIA-H5225-hplc
SIA-H5225-elisa_1
SIA-H52A8 Human Human SIRP alpha / CD172a Protein, Mouse IgG1 Fc Tag (MALS verified)
SIA-H52A8-structure
SIA-H52A8-sds
SIA-H52A8-hplc
SIA-H52A8-elisa_1
SIA-H5251 Human Human SIRP alpha / CD172a Protein, Fc Tag (MALS verified)
SIA-H5251-structure
SIA-H5251-sds
SIA-H5251-hplc
SIA-H5251-elisa_1

Part of Bioactivity data

SIA-HP252-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

Flow Cytometry assay shows that PE-Labeled Human SIRP alpha, Fc Tag (Cat. No. SIA-HP252) can bind to Jurkat cells overexpressing human CD47. 1 μL stock solution per million cells (QC tested).

SIA-HP252-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

FACS analysis shows that the binding of PE-Labeled Human SIRP alpha, Fc Tag (Cat. No. SIA-HP252) to Jurkat cells overexpressing CD47 was inhibited by increasing concentration of neutralizing anti-human CD47 antibody. The IC50 is 0.37 μg/mL (QC tested).

SIA-H5225-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human CD47, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. CD7-H52A5) on Protein A Biosensor, can bind Human SIRP alpha, His Tag (Cat. No. SIA-H5225) with an affinity constant of 1.1 μM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

SIA-H5225-BLI
Human_FcRn_Heterodimer_Protein_Bli

Immobilized Human CD47, Fc Tag (Cat. No. CD7-H5256) on AHC Biosensor, can bind Human SIRP alpha, His Tag (Cat. No. SIA-H5225) with an affinity constant of 0.72 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Customer Reviews

Synonym Name

SIRP alpha,SHPS1,SIRPA,CD172A,BIT,SHPS-1,MFR,MYD-1,MYD1,PTPNS1,SIRPalpha,p84,SIRP-alpha,CD172

Background

Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Clinical and Translational Updates

Related Molecule

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Elagolix/estradiol/norethindrone acetate Approved Abbvie Inc Oriahnn United States Menorrhagia Abbvie Inc 2020-05-29 Menorrhagia Details
Relugolix/Estradiol/Norethindrone Acetate Approved Myovant Sciences MYFEMBREE EU Leiomyoma Gedeon Richter Plc 2021-05-26 Leiomyoma; Menorrhagia Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
CC-95251 CC-95251 Phase 1 Clinical Celgene Corp Hematologic Neoplasms Details
BI-765063 OSE-172; BI-765063 Phase 1 Clinical Ose Immunotherapeutics Solid tumours Details
ALX-148 ALX148; ALX-148 Phase 3 Clinical Alexo Therapeutics Head and Neck Neoplasms; Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Squamous Cell Carcinoma of Head and Neck; Myelodysplastic Syndromes; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Adenocarcinoma; Neoplasm Metastasis Details

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