Acrobiosystems for English
icon_bulk_orderBulk inquiry/Quick order
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > 4-1BB Ligand

4-1BB Ligand

Brief Information

Name:Tumor necrosis factor ligand superfamily member 9
Target Synonym:4-1BB ligand,4-1BBL
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

Product ListCompare or Buy

ACRO Quality

Part of Bioactivity data

CHEK-ATP039-Cell-based assay
 4-1BB Ligand FACS

FACS assay shows that Biotinylated Human 4-1BB, Fc,Avitag (41B-H82F8) can bind to HEK293/Human 4-1BB Ligand / TNFSF9 Stable Cell Line (CHEK-ATP039). HEK293/Human 4-1BB Ligand / TNFSF9 Stable Cell was red line, Negative control HEK293 cells was grey line (QC tested).

GMP-41LH26-Cell-based assay
 4-1BB Ligand CELL

GMP Human 4-1BB Ligand Protein, Fc Tag (Cat. No. GMP-41LH26) induce IL‐8 secretion in HT1080 human CD137 cell line. The specific activity of GMP Human 4-1BB Ligand Protein, Fc Tag is>1.00 x 10^5 U/mg (QC tested).

 4-1BB Ligand SPR

Biotinylated Human 4-1BB Ligand (71-254), Fc,Avitag, premium grade (Cat. No. 41L-H82Fa) captured on Protein A Chip can bind Human 4-1BB, His Tag (Cat. No. 41B-H52Hc) with an affinity constant of 342 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

 4-1BB Ligand BLI

Loaded Mouse 4-1BB, Fc Tag (Cat. No. 41B-M5258) on Protein A Biosensor, can bind Human 4-1BB Ligand (71-254) Protein, His,Flag Tag (Cat. No. 41L-H52D4) with an affinity constant of 18.6 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

4-1BB Ligand,TNFSF9,CD137L


Tumor necrosis factor ligand superfamily member 9 (4-1BBL) is also known as 4-1BB ligand, CD137L or TNFSF9, which is a cytokine that binds to TNFRSF9. 4-1BBL is the high affinity ligand of 4-1BB. 4-1BBL induces the proliferation of activated peripheral blood T-cells. Also, 4-1BBL may have a role in activation-induced cell death (AICD). Furthermore, 4-1BBL may play a role in cognate interactions between T-cells and B-cells/macrophages. As for diseases, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
RTX-224 RTX-224 Phase 2 Clinical Rubius Therapeutics Inc Skin Melanoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Carcinoma, Non-Small-Cell Lung Details
RP-3 RP-3 Phase 2 Clinical Replimune Inc Solid tumours; Liver Neoplasms; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms; Carcinoma, Hepatocellular Details

This web search service is supported by Google Inc.

Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
+1 888-377-6111
1 Innovation Way, Newark, DE 19711, USA

Leave a message