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Your Position: Home > Integrin alpha V beta 8

Integrin alpha V beta 8

Brief Information

Name:integrin alpha V/beta 8
Target Synonym:alphavbeta8 integrin
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
IT8-M52W7 Mouse Biotinylated Mouse Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)
IT8-M52W7-structure
IT8-M52W7-sds
IT8-R52E1 Rat Rat Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein, His Tag&Tag Free (MALS verified)
IT8-R52E1-structure
IT8-R52E1-sds
IT8-C52W9 Cynomolgus Cynomolgus Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein, His Tag&Tag Free (MALS verified)
IT8-C52W9-structure
IT8-C52W9-sds
IT8-M52W6 Mouse Mouse Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein, His Tag&Tag Free (MALS verified)
IT8-M52W6-structure
IT8-M52W6-sds
IT8-H82W5 Human Biotinylated Human Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)
IT8-H82W5-structure
IT8-H82W5-sds
IT8-H52W4 Human Human Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein, His Tag&Tag Free
IT8-H52W4-structure
IT8-H52W4-sds
ACRO Quality

Part of Bioactivity data

IT8-R52E1-ELISA
Integrin alpha V beta 8 ELISA

Immobilized Rat Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer, His Tag&Tag Free (Cat. No. IT8-R52E1) at 5 μg/mL (100 μL/well) can bind Biotinylated Human Latent TGF-Beta 1, His,Avitag (Cat. No. TG1-H82Qb) with a linear range of 0.2-13 ng/mL (QC tested).

Protocol
IT8-M52W7-MALS-HPLC
Integrin alpha V beta 8 MALS images

The purity of Biotinylated Mouse ITGAV&ITGB8 Heterodimer Protein (Cat. No. IT8-M52W7) is more than 85% and the molecular weight of this protein is around 195-245 kDa verified by SEC-MALS.

Synonym Name

Integrin alpha V beta 8,ITGAV&ITGB8

Background

Integrin alpha V beta 8 (ITGAV & ITGB8 or ITGAVB8) is expressed in yolk sac, placenta, brain perivascular astrocytes, Schwann cells, renal glomerular mesangial cells and pulmonary epithelial cells. Unlike other alpha V integrins, ITGAVB8 does not appear to assume different activation states, and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif, including vitronectin, fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP, which releases active TGF-beta. This mechanism differs from that of alpha V beta 6, the other alpha V integrin which can activate TGF-beta from latency through non-proteolytic mechanisms. Downstream effects of TGF-beta activation include control of cell growth and associated vascularization.

Clinical and Translational Updates

Related Molecule

TGF-Beta 1

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Nesvategrast OTT-166(OcuTerra Therapeutics); SF-0166 Phase 2 Clinical Scifluor Life Sciences Inc, OcuTerra Therapeutics Inc Diabetic macular oedema; Diabetic Retinopathy; Macular Degeneration Details
CRB-601 CRB-601 Phase 2 Clinical Uc San Francisco, Corbus Pharmaceuticals Holdings Inc Solid tumours Details

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