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BAFFR Molecule Information

Name:B-cell activating factor receptor
Target Synonym:BAFF-R;TNFRSF13C;BAFFR;BR3;B-cell-activating factor receptor;BAFF receptor;BLyS receptor 3;CD268
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase ?

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BAFFR Part of Bioactivity data


Immobilized Human BAFF, Fc Tag, active trimer (Cat. No. BAF-H5261) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human BAFFR, Llama IgG2b Fc Tag, low endotoxin (Cat. No. BAR-H5258) with an affinity constant of 44.5 nM as determined in a SPR assay (Biacore T200) (Routinely tested).


Immobilized Biotinylated Human BAFF, Avitag,Fc Tag (active trimer) (MALS verified) (Cat. No. BAF-H82F3) on SA Chip can bind Human BAFFR, Fc Tag (Cat. No. BAR-H5257) with an affinity constant of 26.7 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

BAFFR Molecule Synonym Name


BAFFR Molecule Background

BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

BAFFR References

BAFFR Related Molecule

BAFFR Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Briobacept Phase Ⅱ Biogen Idec, Genentech Chronic lymphocytic leukemia (CLL), Sjoegren's syndrome, Rheumatoid arthritis (RA) Details
Ianalumab NOV-5; VAY-736 Phase Ⅲ MorphoSys, Novartis Autoimmune hepatitis Details

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