BAFFR

BAFFR Molecule Information

Name：B-cell activating factor receptor
Target Synonym：BAFF-R?TNFRSF13C?BAFFR?BR3?B-cell-activating factor receptor?BAFF receptor?BLyS receptor 3?CD268

Number of Launched Drugs：0
Number of Drugs in Clinical Trials：2
Lastest Research Phase：Phase ?

BAFFR Protein Product ListCompare or Buy

Cat. No.	Species	Product Description
BAR-H5258	Human	Human BAFFR / TNFRSF13C Protein, Llama IgG2b Fc Tag, low endotoxin
BAR-H5257	Human	Human BAFFR / TNFRSF13C Protein, Fc Tag
BAR-M5259	Mouse	Mouse BAFFR / TNFRSF13C Protein, Fc Tag
BAR-M82F0	Mouse	Biotinylated Mouse BAFFR /TNFRSF13C Protein, Fc Tag, Avi Tag (Avitag™)

BAFFR Molecule Synonym Name

BAFFR,TNFRSF13C,BAFF-R,BROMIX,CD268,CVID4,prolixin

BAFFR Molecule Background

BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

BAFFR References

BAFFR Related Molecule

BAFF

BAFFR Clinical Drug Information

Name	Research Code	Research Phase	Company	Indications	Clinical Trials
Briobacept		Phase Ⅱ	Biogen Idec, Genentech	Chronic lymphocytic leukemia (CLL), Sjoegren's syndrome, Rheumatoid arthritis (RA)	Details
Ianalumab	NOV-5; VAY-736	Phase Ⅱ	MorphoSys, Novartis	Sjoegren's syndrome, Multiple sclerosis (MS), Rheumatoid arthritis (RA), Pemphigus vulgaris	Details