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>Recombinant ROR1 & ROR2 Proteins
ROR family includes receptor tyrosine kinases ROR1 and ROR2. ROR1 is of particular interest to the pharmaceutical community, because its expression is only observed in embryonic and cancerous cells, but not in health adult tissues. This feature makes it an ideal drug target for several cancer types. Multiple ROR1-targeted therapies are underdevelopment, including Oncternal’s Cirmtuzumab.
The extracellular domain of ROR1 is made of three distinct domains, an immunoglobulin-like (Ig) domain, a frizzled domain, and a kringle domain (Borcherding et al., 2014). Interestingly, antibodies targeting different domains demonstrate a marked difference in therapeutic efficacy when used to treat leukemia cell lines (Daneshmanesh et al., 2013).
ACROBiosystems provides a comprehensive panel of human ROR1 proteins, including product of each single domain (Ig-like, Frizzled, Kringle), and the entire ECD of all three domains. We also have pre-biotinylated ROR1 (ECD). These proteins are generated using Avitag technology. The biotin tag is precisely conjugated on the single Avitag introduced at the C-terminus of the protein. This site-specific labeling method has many advantages over the commonly used NHS-labeling. It not only 100% preserves the protein's natural structure, but also confers uniform labeling efficiency and bioactivity. These pre-labeled products have been used to screen for anti-ROR1 mAbs. Moreover, we also developed mouse and rat ROR1 proteins for animal studies. (see full product list below)
Fig.1 Loaded Anti-Human ROR1 mAb (Mouse IgG1) on AMC Biosensor, can bind Human ROR1, His Tag (Cat. No. RO1-H522y) with an affinity constant of 10.2 nM as determined in BLI assay (ForteBio Octet Red96e).
Fig.2 Immobilized Anti-Human ROR1 mAb at 2 μg/mL (100 μL/well) can bind Biotinylated Human ROR1, His,Avitag (Cat. No. RO1-H82E6) with a linear range of 0.5-4 ng/mL.
|Cat. No.||Product Description||Structure||Domain|
|RO1-M5250||Mouse ROR1 Protein, Fc Tag|
|RO1-M5221||Mouse ROR1 Protein, His Tag|
|Biotinylated Human ROR1 Protein, His,Avitag™||Full ECD|
|Biotinylated Human ROR1 Protein, Fc,Avitag™||Full ECD|
|RO1-R5221||Rat ROR1 Protein, His Tag|
|Biotinylated Human ROR1 Protein, Avitag™||Full ECD|
|RO1-H5250||Human ROR1 Protein, Fc Tag||Full ECD|
|RO1-H522y||Human ROR1 Protein, His Tag||Full ECD|
|RO1-H5221||Human ROR1 (39-151, Ig-like domain) Protein, His Tag||Ig-like|
|RO1-H5223||Human ROR1 (308-395, Kringle domain) Protein, His Tag||Kringle|
|RO1-H5222||Human ROR1 (165-305, Frizzled domain) Protein, His Tag||Frizzled|
|Cat. No.||Product Description||Structure|
|Biotinylated Human ROR2 / NTRKR2 Protein, His,Avitag™|
|RO2-M5253||Mouse ROR2 / NTRKR2 Protein, Fc Tag|
|RO2-H5251||Human ROR2 / NTRKR2 Protein, Fc Tag|
|RO2-H52E5||Human ROR2 / NTRKR2 Protein, His Tag|
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