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Biotinylated CD3E & more CD3 products

The T-cell receptor (TCR) does not signal on its own. Instead, it is constitutively associated with the CD3 coreceptors, which contain intracellular signaling apparatus, consisting of the CD3εγ and CD3εδ heterodimers and the CD3ζζ homodimer (Wucherpfennig KW, et al., 2010; Kuhns MS, et al., 2012). CD3 has become a focal point of pharmaceutical research in the last decades. Direct inhibition of CD3 protein has been used to treat autoimmune diseases and allograft rejection. OKT3, the first mouse monoclonal antibody specific for human CD3, was produced in 1979 by P. Kung and G. Goldstein (Kung P, et al., 1979). It was also the first monoclonal antibody to be used in clinical practice, in the field of transplantation.

Biotinylated CD3E and more CD3 products

More recently, targeting CD3 has been used as a strategy to bridge cytotoxic T cells to target cells in bi-specific antibody design. A successful example is Amgen’s Blincyto® (blinatumomab). Blinatumomab is a bi-specific antibody simultaneously targeting CD3 and CD19, and by so doing directing the CD3-expressing T cells to CD19-expressing lymphoma cells (Nagorsen D, et al., 2012). The capacity of CD3-specific antibody therapy to promote tolerance, a concept that has been proven for autoimmune diabetes, could be extended to other autoimmune diseases and transplantation.

ACROBiosystems provides a comprehensive panel of CD3 proteins, including the exclusive Biotinylated Human CD3 epsilon (Cat. No. CDE-H8223), and the Biotinylated Human CD3E & CD3D heterodimer protein (Cat. No. CDD-H82W0). We are also the only supplier for Mouse CD3 epsilon protein (Cat. No. CDE-M5256).

CD3 Product Highlight

Biotinylated Human CD3E,His Tag ELISA
Immobilized Anti-Human CD3 Mab, mouse IgG1 (Clone # SP34-2) at 2 μg/mL (100 μL/well) can bind Biotinylated Human CD3E, His Tag (Cat. No. CDE-H8223) with a linear range of 0.05-2 ng/mL.
Biotinylated Human CD3E and CD3D ELISA
Immobilized Biotinylated Human CD3E & CD3D (Cat. No. CDD-H82W0) can bind OKT3 with a linear range of 2-39 ng/mL. The biotinylated CD3E & CD3D heterodimers are coated at 1 ug/mL (100 μL/well) on a streptavidin coated plates.

CD3 Product List

MoleculeCat. No.SpeciesStructurePurityFeatures
CD3 epsilon
(Biotin-labeled)
CDE-H8223
CDE-H8223-STC1

CD3 epsilonCDE-H5223
CDE-H5223-STC1

CD3 epsilonCDE-H5256
CDE-H5256-STC1

CD3 epsilonCDE-H5286
CDE-H5286-STC1

CD3 epsilonCDE-M5256
CDE-M5256-STC1
CD3 epsilonCDE-C5226
CDE-C5226-STC1

CD3 epsilonCDE-C5254
CDE-C5254-STC1

CD3 deltaCDD-H5224
CDD-H5224-STC1
CD3 deltaCDD-C52H8
CDD-C52H8-STC1
CD3E & CD3D
(Biotin-labeled)
CDD-H82W0
CDD-H82W0-STC1

CD3E & CD3DCDD-H52W4
CDD-H52W4-STC1

CD3E & CD3DCDD-H52W0
CDD-H52W0-STC1

CD3E & CD3DCDD-C52W4
CDD-C52W4-STC1

CD3E & CD3GCDG-H52W9
CDG-H52W9-STC1

Related products

MoleculeCat. No.SpeciesStructurePurityFeatures
CD4
(Biotin-labeled)
CD4-H82E8
CD4-H82E8-STC1

CD4
(Biotin-labeled)
CD4-H82F3
CD4-H82F3-STC1

CD4LE3-H5228
LE3-H5228-STC1

CD4CD4-H5259
CD4-H5259-STC1

CD4CD4-C52H7
CD4-C52H7-STC1
CD4CD4-C5256
CD4-C5256-STC1

References

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