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Project Name | Modality | Therapeutic Area | Indications | Stage | Right Available |
CD40 mAb | Monospecific antibody | Oncology/Cancer | Advanced solid tumor | Phase I | Global |
Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
---|---|---|---|---|---|
CD40L-GVAX | GM.CD40L; CD40L-GVAX; GM-CSF/CD40L; hCD40L/hGM-CSF | Phase 2 Clinical | University Of South Florida | Leukemia; Small Cell Lung Carcinoma; Myelodysplastic Syndromes; Adenocarcinoma of Lung; Lung Neoplasms; Adenocarcinoma; Melanoma | Details |
Giloralimab | ABBV-927 | Phase 2 Clinical | Abbvie Inc | Solid tumours; Head and Neck Neoplasms; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Neoplasms; Carcinoma, Non-Small-Cell Lung | Details |
BI-655064 | BI-655064 | Phase 2 Clinical | C.H. Boehringer Sohn Ag & Co. Kg | Purpura, Thrombocytopenic, Idiopathic; Arthritis, Rheumatoid; Lupus Nephritis | Details |
Mitazalimab | ADC-1013; JNJ-7107; JNJ-64457107 | Phase 2 Clinical | Alligator Bioscience Ab | Solid tumours; Pancreatic Neoplasms; Neoplasms; Carcinoma, Pancreatic Ductal | Details |
Sotigalimab | APX-005M; EPI-0050; APX-005 | Phase 2 Clinical | Epitomics Inc | Head and Neck Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Carcinoma, Renal Cell; Skin Neoplasms; Neoplasms; Carcinoma, Transitional Cell; Pancreatic Neoplasms; Microsatellite Instability; Lung Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung | Details |
Iscalimab | CFZ-533; NVP-CFZ533; OM11-62-MF | Phase 2 Clinical | Novartis Pharma Ag | Rejection of renal transplantation; Myasthenia Gravis; Diabetes Mellitus, Type 1; Rejection of liver transplantation; Sjogren's Syndrome; Arthritis, Rheumatoid; Lupus Nephritis; Graves Disease; Lupus Erythematosus, Systemic; Sjogren-Larsson Syndrome; Hidradenitis Suppurativa | Details |
Anti-CD40 ChiLob7/4 (BioNTech) | Phase 2 Clinical | Biontech Se | Head and Neck Neoplasms; Pancreatic Neoplasms | Details | |
CDX-1140 | CDX-1140 | Phase 2 Clinical | Celldex Therapeutics | Colorectal Neoplasms; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Sarcoma; Breast Neoplasms; Osteosarcoma; Cholangiocarcinoma; Bile Duct Neoplasms; Peritoneal Neoplasms; Urinary Bladder Neoplasms; Carcinoma, Squamous Cell; Waldenstrom Macroglobulinemia; Lymphoma, Non-Hodgkin; Fallopian Tube Neoplasms; Lung Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung; Leukemia, Lymphocytic, Chronic, B-Cell; Carcinoma, Merkel Cell; Liver Neoplasms; Ovarian Neoplasms; Head and Neck Neoplasms; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Solid tumours; Carcinoma, Renal Cell; Carcinoma; Biliary Tract Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Neoplasms; Lymphoma, Large B-Cell, Diffuse; Uveal melanoma | Details |
Bleselumab | 4D-11; ASKP-1240 | Phase 2 Clinical | Kyowa Hakko Kogyo Co Ltd | Rejection of renal transplantation; Rejection of organ transplantation; Psoriasis; Glomerulosclerosis, Focal Segmental | Details |
Tecaginlimab | BNT-312; GEN-1042 | Phase 2 Clinical | Genmab A/S | Solid tumours; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms; Peripheral Nervous System Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung; Melanoma | Details |
Ravagalimab | ABBV-323; PR-1629977 | Phase 2 Clinical | Abbvie Inc | Sjogren's Syndrome; Colitis, Ulcerative | Details |
CD40.RBDv vaccin(LinKinVax) | Phase 2 Clinical | LinKinVax, ANRS, Emerging Infectious Diseases, Vaccine Research Institute (VRI), France | Coronavirus Disease 2019 (COVID-19) | Details | |
DFI-105 | DFI105; DFI-105 | Phase 2 Clinical | Diabetes Free Inc | Diabetes Mellitus, Type 2 | Details |
HPV CD40 HVac | Phase 2 Clinical | LinKinVax | Head and Neck Neoplasms; Oropharyngeal Neoplasms | Details | |
Cifurtilimab | SEA-CD40 | Phase 2 Clinical | Head and Neck Neoplasms; Lymphoma, B-Cell; Squamous Cell Carcinoma of Head and Neck; Neoplasms, Squamous Cell; Pancreatic Neoplasms; Hodgkin Disease; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Follicular; Carcinoma, Squamous Cell; Lymphoma, Non-Hodgkin; Lymphoma; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Melanoma | Details | |
MIL-97 | MIL-97 | Phase 2 Clinical | Beijing Mabworks Biotech Co Ltd | Solid tumours; Pancreatic Neoplasms | Details |
Dalnicastobart | LVGN7409; LVGN-7409 | Phase 2 Clinical | Lyvgen Biopharma(HK)Ltd | Ovarian Neoplasms; Head and Neck Neoplasms; Solid tumours; Stomach Neoplasms; Esophageal Neoplasms; Papillomavirus Infections; Neoplasms; Uveal melanoma; Sarcoma; Carcinoma, Hepatocellular; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung | Details |
2141-V11 | 2141-V11 | Phase 2 Clinical | The Rockefeller University | Solid tumours; Ganglioglioma; Neoplasms; Skin Neoplasms; Glioblastoma; Urinary Bladder Neoplasms; Glioma | Details |
YH-003 | YH-003; YH003 | Phase 2 Clinical | Eucure Pharmaceutical Technology (Beijing) Co Ltd | Solid tumours; Pancreatic Neoplasms; Carcinoma, Pancreatic Ductal; Melanoma | Details |
Abiprubart | KPL-404 | Phase 2 Clinical | Primatope Therapeutics Inc | Arthritis, Rheumatoid | Details |
NJA-730 | NJA-730; NJA-730a; NJA-730b | Phase 1 Clinical | Napajen Pharma | Autoimmune Diseases | Details |
Selicrelumab | RG-7876; RO-7009789 | Phase 1 Clinical | F. Hoffmann-La Roche Ltd | Solid tumours; Neoplasms; Pancreatic Neoplasms; Lymphoma, Non-Hodgkin | Details |
Autologous IL2 and CD40 ligand-expressing tumor cells (Baylor College of Medicine) | Phase 1 Clinical | Baylor College Of Medicine | Leukemia, Lymphocytic, Chronic, B-Cell | Details | |
ABBV-428 | ABBV-428; ABBV428 | Phase 1 Clinical | Abbvie Inc | Solid tumours | Details |
MEDI-5083 | MEDI-5083 | Phase 1 Clinical | Astrazeneca Plc, Medimmune | Solid tumours | Details |
NG-350A | NG-350A | Phase 1 Clinical | Akamis Bio Ltd | Neoplasms, Glandular and Epithelial; Neoplasm Metastasis | Details |
SL-172154 | SL-172154 | Phase 1 Clinical | Shattuck Labs Inc | Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Ovarian Epithelial; Myelodysplastic Syndromes; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Squamous Cell; Leukemia, Myeloid, Acute | Details |
LNF-1901 | LNF-1901; LNF1901 | Phase 1 Clinical | Lunan Pharmaceutical Group Co | Neoplasms | Details |
B-901 | B-901; B901 | Phase 1 Clinical | FutureGen Biopharm (Beijing) Co Ltd | Solid tumours | Details |
SHR-7367 | SHR7367; SHR-7367 | Phase 1 Clinical | Shanghai Hengrui Pharmaceutical Co Ltd | Solid tumours; Neoplasms | Details |
SHR-1704 | SHR-1704 | Phase 1 Clinical | Jiangsu Hengrui Medicine Co Ltd | Neoplasms | Details |
IMB-071703 | IMB-071703; IMB071703 | Phase 1 Clinical | Beijng Immunoah Pharma Tech Co Ltd | Solid tumours | Details |
ILB-2101 | ILB-2101 | Phase 1 Clinical | Innolake Biopharm (Hangzhou) Co Ltd | Neoplasms | Details |
HBM-9027 | HBM-9027; HBM9027 | Phase 1 Clinical | Harbour Biomed | Solid tumours; Neoplasms | Details |
BSI-038 | BSI-038 | Phase 1 Clinical | Boaoxin Biotechnology(Nanjing) Co Ltd | Solid tumours | Details |
TQB-2916 | TQB2916; TQB-2916 | Phase 1 Clinical | Nanjing Shunxin Pharmaceuticals Co Ltd Of Chiatai Tianqing Pharmaceutical Group | Neoplasms | Details |
RO-7300490 | RO-7300490; RG-6189 | Phase 1 Clinical | F. Hoffmann-La Roche Ltd | Solid tumours; Neoplasms | Details |
CD40.HIVRI.Env Vaccine | Phase 1 Clinical | Anrs, LinKinVax | HIV Infections | Details | |
Inezetamab | AMG-994 | Phase 1 Clinical | Amgen Inc | Solid tumours | Details |
BMS-986325 | Y 12XX-hz28-P238K | Phase 1 Clinical | Bristol-Myers Squibb Company | Sjogren's Syndrome | Details |
OPT-101 | Phase 1 Clinical | Op-T LLC | Diabetes Mellitus, Type 1 | Details | |
NWY-001(Biocytogen Pharmaceuticals) | NWY001(Biocytogen Pharmaceuticals); YH008; YH-008; NWY-001(Biocytogen Pharmaceuticals) | Phase 1 Clinical | Eucure Pharmaceutical Technology (Beijing) Co Ltd, Biocytogen Pharmaceuticals (Beijing) Co Ltd | Solid tumours; Hematologic Neoplasms; Neoplasms | Details |
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