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Your Position: Home > CD40

CD40

Brief Information

Name:Tumor necrosis factor receptor superfamily member 5
Target Synonym:Bp50,CD40 Antigens,CD40,B Cell Surface Antigen CD40,B-Cell Surface Antigen CD40,CDW40,CD40L Receptor,CD40 Molecule,Tumor Necrosis Factor Receptor Superfamily, Member 5,CD40 Molecule, TNF Receptor Superfamily Member 5,TNFRSF5,Tumor Necrosis Factor Receptor Superfamily Member 5,P50,CD40 Antigen,B Cell-Associated Molecule
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:43
Lastest Research Phase:Phase 2 Clinical

Licensing

Project Name Modality Therapeutic Area Indications Stage Right Available
CD40 mAb Monospecific antibody Oncology/Cancer Advanced solid tumor Phase I Global

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Cat. No. Species Product Description Structure Purity Feature
CD0-H52H4 Human Human CD40 / TNFRSF5 Protein, His Tag, Ultra Low Endotoxin (MALS verified)
CD0-H52H4-structure
CD0-H52H4-sds
CD0-HA256 Human Alexa Fluor™ 647-Labeled Human CD40 Protein, Fc Tag (Site-specific conjugation)
CD0-HA256-structure
CD0-R52H8 Rat Rat CD40 / TNFRSF5 Protein, His Tag (MALS verified)
CD0-R52H8-structure
CD0-R52H8-sds
CD0-M82F3 Mouse Biotinylated Mouse CD40 / TNFRSF5 Protein, Fc,Avitag™ (MALS verified)
CD0-M82F3-structure
CD0-M82F3-sds
CD0-R52H9 Rabbit Rabbit CD40 / TNFRSF5 Protein, His Tag (MALS verified)
CD0-R52H9-structure
CD0-R52H9-sds
CD0-H525a Human Human CD40 / TNFRSF5 Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)
CD0-H525a-structure
CD0-H525a-sds
TN5-H82F9 Human Biotinylated Human CD40 / TNFRSF5 Protein, Fc,Avitag™ (MALS verified)
TN5-H82F9-structure
TN5-H82F9-sds
CD0-H82E8 Human Biotinylated Human CD40 / TNFRSF5 Protein, Avitag™,His Tag (MALS verified)
CD0-H82E8-structure
CD0-H82E8-sds
CD0-C52H6 Cynomolgus Cynomolgus CD40 / TNFRSF5 Protein, His Tag (MALS verified)
CD0-C52H6-structure
CD0-C52H6-sds
TN5-M52H8 Mouse Mouse CD40 / TNFRSF5 Protein, His Tag (MALS verified)
TN5-M52H8-structure
TN5-M52H8-sds
TN5-M5259 Mouse Mouse CD40 / TNFRSF5 Protein, Fc Tag
TN5-M5259-structure
TN5-M5259-sds
CD0-C5259 Rhesus macaque Rhesus macaque CD40 / TNFRSF5 Protein, Fc Tag (MALS verified)
CD0-C5259-structure
CD0-C5259-sds
CD0-C52H7 Rhesus macaque Rhesus macaque CD40 / TNFRSF5 Protein, His Tag (MALS verified)
CD0-C52H7-structure
CD0-C52H7-sds
CD0-H5228 Human Human CD40 / TNFRSF5 Protein, His Tag (MALS verified)
CD0-H5228-structure
CD0-H5228-sds
CD0-H5253 Human Human CD40 / TNFRSF5 Protein, Fc Tag (MALS verified)
CD0-H5253-structure
CD0-H5253-sds
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Customer Reviews

Synonym Name

CD40,Bp50,CDW40,MGC9013,TNFRSF5,p50

Background

CD40 is also known as TNFRSF5, Bp50, CDW40, MGC9013, TNFRSF5 and  p50, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins, and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 contains 4 cysteine-rich repeats in the extracellular domain, and is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. The extracellular domain has the cysteinerich repeat regions, which are characteristic for many of the receptors of the TNF superfamily. Interaction of CD40 with its ligand, CD40L, leads to aggregation of CD40 molecules,which in turn interact with cytoplasmic components to initiate signaling pathways. Early studies on the CD40-CD40L system revealed its role in humoral immunity. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3), an autosomal recessive disorder characterized by an inability of B cells to undergo isotype switching, as well as an inability to mount an antibody-specific immune response, and a lack of germinal center formation.

Clinical and Translational Updates

Related Molecule

CD40 ligand

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