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PD-L1

PD-L1 Molecule Information

Name:Programmed death-ligand 1
Target Synonym:Programmed death ligand 1?B7 homolog 1?CD_antigen=CD274?Programmed cell death 1 ligand 1?B7H1 ?PDCD1L1?PDCD1LG1?CD274?PD-L1?B7-H1?PDL1?PDCD1 ligand 1
Number of Launched Drugs:3
Number of Drugs in Clinical Trials:36
Lastest Research Phase:Approved

PD-L1 Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
PDL-H5250 Human Human PD-L1 / B7-H1 Protein, Llama IgG2b Fc Tag, low endotoxin
PDL-H5250-structure
PDL-H5250-sds
PDL-H5250-elisa_1
PDL-H82F2 Human Biotinylated Human PD-L1 / B7-H1 Protein, Fc Tag, Avi Tag (Avitag™)
PDL-H82F2-structure
PDL-H82F2-sds
PDL-H82F2-elisa_1
PD1-M52A2 Mouse Mouse PD-L1 / B7-H1 Protein, mouse IgG2a Fc Tag, low endotoxin
PD1-M52A2-structure
PD1-M52A2-sds
PD1-M52A2-elisa_1
PD1-H82E5 Human Biotinylated Human PD-L1 / B7-H1 (recommended for biopanning) Protein, His Tag, Avi Tag (Avitag™)
PD1-H82E5-structure
PD1-H82E5-sds
PD1-H82E5-elisa_1
PD1-M82F5 Mouse Biotinylated Mouse PD-L1 / B7-H1, Fc Tag, Avi Tag (Avitag™)
PD1-M82F5-structure
PD1-M82F5-sds
PD1-M82F5-elisa_1
PD1-M5220 Mouse Mouse PD-L1 / B7-H1 Protein
PD1-M5220-structure
PD1-M5220-sds
PD1-M5220-elisa_1
PD1-M5251 Mouse Mouse PD-L1 / B7-H1 Protein, Fc Tag
PD1-M5251-structure
PD1-M5251-sds
PD1-M5251-elisa_1
PD1-H52A3 Human Human PD-L1 / B7-H1 Protein, mouse IgG1 Fc Tag, low endotoxin (HPLC-verified)
PD1-H52A3-structure
PD1-H52A3-sds
PD1-H52A3-hplc
PD1-H52A3-elisa_1
PD1-C52H4 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque PD-L1 / B7-H1 Protein
PD1-C52H4-structure
PD1-C52H4-sds
PD1-C52H4-elisa_1
PD1-C52H4-elisa_2
PD1-C5253 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque PD-L1 / B7-H1 Protein, Fc Tag
PD1-C5253-structure
PD1-C5253-sds
PD1-C5253-elisa_1
PD1-H82F3 Human Biotinylated Human PD-L1 / B7-H1, His Tag & Fc Tag, Avi Tag (Avitag™)
PD1-H82F3-structure
PD1-H82F3-sds
PD1-H82F3-elisa_1
PD1-H5282 Human Human PD-L1 / B7-H1 Protein, Strep Tag
PD1-H5282-structure
PD1-H5282-sds
PD1-H5282-elisa_1
PD1-H5258 Human Human PD-L1 / B7-H1 Protein, Fc Tag (HPLC-verified)
PD1-H5258-structure
PD1-H5258-sds
PD1-H5258-hplc
PD1-H5258-elisa_1
PD1-H5229 Human Human PD-L1 / B7-H1 Protein, His Tag (HPLC-verified)
PD1-H5229-structure
PD1-H5229-sds
PD1-H5229-hplc
PD1-H5229-elisa_1
PD1-H5229-elisa_2

PD-L1 Molecule Synonym Name

PD-L1,CD274,B7-H1,PDCD1L1,PDCD1LG1

PD-L1 Molecule Background

Programmed cell death 1 ligand 1 (PD-L1) is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. PD-L1 is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 involve in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.

PD-L1 References

PD-L1 Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Atezolizumab MPDL-3280A; RG-7446; RO-5541267; 52CMI0WC3Y (UNII code) ,MPDL3280A,RG7446 Approved Genentech TECENTRIQ fda Non small cell lung cancer (NSCLC) GENENTECH INC 2016-10-18 Non small cell lung cancer (NSCLC), Urothelial cancer Details
Durvalumab MEDI-4736,MEDI4736,28X28X9OKV (UNII code) Approved MedImmune, Celgene IMFINZI fda Urothelial cancer ASTRAZENECA UK LTD 2017-05-01 Non small cell lung cancer (NSCLC), Urothelial cancer Details
Avelumab MSB-0010718C; PF-06834635 ,MSB0010718C,PF06834635  Approved Merck Serono, Pfizer BAVENCIO fda Merkel cell carcinoma EMD SERONO INC 2017-03-23 Merkel cell carcinoma, Urothelial cancer Details

PD-L1 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Pd-1-pik Pd-1-pik Phase Ⅰ Huashan Hospital of Fudan University Glioblastoma multiforme Details
Recombinant human anti-PD-L1 monoclonal antibody (Zhaoke Oncology) STI-A1014; ZKAB-001,STIA1014; ZKAB001; STIA-1014 Phase Ⅰ Zhaoke Oncology Solid tumours Details
CA-327 CA-327; AUPM-327 Preclinical Aurigene, Curis Cancer Details
JS-003 JS-003,JS003; JS 003 Phase Ⅰ Shanghai Junshi Biosciences Solid tumours Details
BMS-986189 BMS-189; BMS-986189; PD-L1-Milla; BMS-986189-07 Phase Ⅰ Bristol-Myers Squibb Sepsis Details
M-7824 M-7824; MSB0011359C,M7824; MSB-0011359C Phase Ⅱ Merck Serono Prostate cancer, Solid tumours Details
Anti-PDL1 chimeric switch receptor modified T-cell therapy (Marino Biotechnology) Phase Ⅰ Marino Biotechnology Solid tumours, Glioblastoma Details
CA-170 CA-170; AUPM-170 Phase Ⅱ Aurigene, Curis Cancer Details
KN-046 KN-046,KN046; KN 046 Phase Ⅰ Alphamab Solid tumours Details
Recombinant humanized PD-L1 single domain antibody Fc fusion protein KN-035,KN035; KN 035 Phase Ⅲ Alphamab, 3D Medicines Solid tumours, Biliary cancer Details
CX-072 CX-072,CX072 Phase Ⅱ CytomX Therapeutics Solid tumours, Lymphoma Details
BGB-A333 BGB-A333,BGBA333 Phase Ⅱ BeiGene Solid tumours Details
GR-1405 GR-1405,GR1405; GR 1405 Phase Ⅰ Chongqing Genrix Biopharmaceutical, Genrix (Shanghai) Biopharmaceutical Solid tumours, Lymphoma Details
Anti PD-L1 monoclonal antibody (Biocad) BCD-135 Phase Ⅰ Biocad Solid tumours Details
Recombinant anti-PD-L1 human monoclonal antibody (Hisun Pharm) Phase Ⅰ Hisun Pharm Cancer Details
Chimeric antigen receptor T-cell therapy (Hunan Zhaotai Yongren Biotech) Z-CTLs Phase Ⅰ Hunan Zhaotai Yongren Biotech Non small cell lung cancer (NSCLC) Details
Human source and Fc engineered monoclonal antibody (MabSpace) MSB-2311,MSB2311 Phase Ⅰ MabSpace Biosciences Solid tumours Details
Durvalumab/Osimertinib Mesylate Phase Ⅲ MedImmune Non small cell lung cancer (NSCLC) Details
FAZ-053 FAZ-053,FAZ053 Phase Ⅰ Novartis Solid tumours Details
FS 118 FS-118 Phase Ⅰ F-star, Merck Serono hematological malignancies, Solid tumours Details
Recombinant human anti-PD-L1 monoclonal antibody (Guilin Sanjin) IND Filing Sanjin Pharmaceutical, Adagene Cancer Details
Anti-PDL1 monoclonal antibody (TG Therapeutics) Phase Ⅰ TG Therapeutics Cancer Details
BMS-936559 BMS-936559; MDX-1105; Anti-PD-L1,BMS936559; MDX1105 Phase Ⅱ Bristol-Myers Squibb HIV infection, Solid tumours, Sepsis Details
SHR-1316 SHR-1316 Phase Ⅰ Jiangsu Hengrui Medicine Solid tumours Details
LY-3300054 LY-3300054 Phase Ⅰ Lilly Solid tumours Details
TQB-2450 TQB-2450; CBT-502 Phase Ⅰ CBT, Chiatai Tianqing (CTTQ) Solid tumours Details
A167 KL-A167; A167,A-167,KL A167 Phase Ⅱ Sichuan Kelunbotai Biopharmaceutical, Harbour BioMed Hodgkin lymphoma Details
Y-111 Y-111 Preclinical YZY Bio Non small cell lung cancer (NSCLC), Melanoma Details
KD-045 (Nanjing KAEDI Biotech) KD-045 Phase Ⅰ Nanjing KAEDI Biotech Solid tumours Details
SHR-1702 SHR-1702,SHR1702 Phase Ⅰ Shanghai Hengrui, Jiangsu Hengrui Medicine Malignancies Details
IMC-001 IMC-001,IMC 001,IMC001 Phase Ⅰ Sorrento Therapeutics, ImmuneOncia Therapeutics Solid tumours Details
Durvalumab/Selumetinib Phase Ⅰ AstraZeneca Solid tumours Details
Durvalumab/Gefitinib Phase Ⅱ MedImmune Non small cell lung cancer (NSCLC) Details
Recombinant human anti-PDL1 monoclonal antibody (CStone Pharmaceuticals) CS-1001,WBP-3155 Phase Ⅲ CStone Pharmaceuticals Solid tumours, Lymphoma, Hodgkin lymphoma Details
HLX-20 HLX-20,HLX20; HLX 20 Phase Ⅰ Shanghai Henlius Biotech Solid tumours Details
CK-301 CK-301,CK301 Phase Ⅰ Dana-Farber Cancer Institute, Checkpoint Non small cell lung cancer (NSCLC), Renal cell carcinoma, Merkel cell carcinoma, Urothelial cancer, Mesothelioma, Hodgkin lymphoma, Head and neck cancer, Melanoma Details

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