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CTLA-4

CTLA-4 Product List

Cat. No. Species Product Description Structure Purity Feature
CT4-C82E5 Cynomolgus Biotinylated Cynomolgus / Rhesus macaque CTLA-4, Avi Tag (Avitag™)
CT4-C82E5-structure
CT4-C82E5-sds
CT4-C82E5-elisa_1
CT4-C5256 Cynomolgus Cynomolgus / Rhesus macaque CTLA-4 Protein, Fc Tag
CT4-C5256-structure
CT4-C5256-sds
CT4-C5227 Cynomolgus Cynomolgus / Rhesus macaque CTLA-4 Protein
CT4-C5227-structure
CT4-C5227-sds
CT4-C5227-elisa_1
CT4-H82E1 Human Biotinylated Human CTLA-4, His Tag, Avi Tag (Avitag™)
CT4-H82E1-structure
CT4-H82E1-sds
CT4-H82E1-elisa_1
CT4-H5284 Human Human CTLA-4 / CD152 Protein, Strep Tag
CT4-H5284-structure
CT4-H5284-sds
CT4-H5284-elisa_1
CT4-H52A4 Human Human CTLA-4 / CD152 Protein, mouse IgG2a Fc Tag, low endotoxin
CT4-H52A4-structure
CT4-H52A4-sds
CT4-H5229 Human Human CTLA-4 / CD152 Protein
CT4-H5229-structure
CT4-H5229-sds
CT4-H5229-elisa_1
CT4-H5255 Human Human CTLA-4 / CD152 Protein, Fc Tag
CT4-H5255-structure
CT4-H5255-sds
CT4-H5255-elisa_1
CT4-H82F3 Human Biotinylated Human CTLA-4, Fc Tag, Avi Tag (Avitag™)
CT4-H82F3-structure
CT4-H82F3-sds
CT4-H82F3-elisa_1
CT4-M52A3 Mouse Mouse CTLA-4 / CD152 Protein, mouse IgG2a Fc Tag, low endotoxin
CT4-M52A3-structure
CT4-M52A3-sds
CT4-M52A3-elisa_1
CT4-M52H5 Mouse Mouse CTLA-4 / CD152 Protein
CT4-M52H5-structure
CT4-M52H5-sds
CT4-M52H5-elisa_1
CT4-M5256 Mouse Mouse CTLA-4 / CD152 Protein, Fc Tag
CT4-M5256-structure
CT4-M5256-sds
CT4-M5256-elisa_1
CT4-R5250 Rabbit Rabbit CTLA-4 / CD152 Protein, Fc Tag
CT4-R5250-structure
CT4-R5250-sds
CT4-R5259 Rat Rat CTLA-4 / CD152 Protein, Fc Tag
CT4-R5259-structure
CT4-R5259-sds
CT4-R5259-elisa_1

CTLA-4 Molecule Synonym Name

CTLA4,CD152

CTLA-4 Molecule Background

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA-4, an inhibitory receptor for B7 molecules. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

CTLA-4 References

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