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Your Position: Home > EGF R

EGF R

Brief Information

Name:Epidermal growth factor receptor erbB1
Target Synonym:EC 2.7.10,EC:2.7.10.1,Receptor tyrosine-protein kinase erbB-1,Proto-oncogene c-ErbB-1,Epidermal growth factor receptor,EGFR,Erb-B2 Receptor Tyrosine Kinase 1,ERBB1,ERBB,HER1,Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog (Avian),Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog,Epidermal Growth Factor Receptor Tyrosine Kinase Domain,Cell Growth Inhibiting Protein 40,EC 2.7.10.1,NISBD2,PIG61,MENA,Epidermal Growth Factor Receptor (Avian Erythroblastic Leukemia Viral (V-Erb-B
Number of Launched Drugs:34
Number of Drugs in Clinical Trials:147
Lastest Research Phase:Approved

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Part of Bioactivity data

EGR-H82E3-Cell-based assay
Evaluation of CAR expression

Cells were transfected with anti-EGFR scFv and cultured for 3 days. Three days post-transfection, 1e6 cells were stained for anti-EGFR scFv with Biotinylated Human EGFR, His,Avitag (Cat. No. EGR-H82E3) followed by PE-conjugated streptavidin. Flow Cytometry assay shows that Biotinylated Human EGFR, His,Avitag (Cat. No. EGR-H82E3) can bind to cells expressing anti-EGFR scFv. The concentration of EGFR used is 0.8 µg/mL. (Data are kindly provided by Guangzhou Bio-gene Technology Co. Ltd.)

EGR-H522a-SPR
Human_FcRn_Heterodimer_Protein_SPR

Immobilized Erbitux on CM5 Chip via anti-human Fc IgG, can bind Human EGF R, His Tag, low endotoxin (Cat.No. EGR-H522a) with an affinity constant of 0.492 nM as determined in SPR assay (Biacore T200) ( Routinely tested).

EGR-M5224-SPR
Human_FcRn_Heterodimer_Protein_SPR

Captured Mouse EGF R, His Tag (Cat. No. EGR-M5224) on CM5 Chip via anti-His antibody can bind Mouse EGF, Fc Tag (Cat. No. EGF-M5265) with an affinity constant of 5.44 nM as determined in SPR assay (Biacore T200) (Routinely tested).

Synonym Name

EGFR,ERBB,ERBB1,HER1,PIG61,mENA

Background

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Recombinant Human Epidermal Growth Factor Derivative Eye Drops (Shenzhen Wastin Genetech) Approved Shenzhen Watsin Genetech Ltd 金因舒, GeneSoft Mainland China Corneal Diseases Shenzhen Watsin Genetech Ltd 2004-01-21 Corneal Diseases Details
Cetuximab C-255; ch-225; IMC-C255; BMS-564717; EMD-271786; GT-MAB-5.2; LY-2939777; NSC-714692 Approved Bristol-Myers Squibb Company, Eli Lilly And Company, Merck Serono 爱必妥, Erbitux Japan Colorectal Neoplasms; Head and Neck Neoplasms Merck Serono 2004-02-12 Head and Neck Neoplasms; Ovarian Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Neoplasms; Colorectal Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
Erlotinib Hydrochloride CP-358774; OSI-774; R-1415; RG-1415; CP-358774-01; RO-0508231; NSC-718781 Approved Genentech Inc Tarceva, 特罗凯 Japan Carcinoma, Non-Small-Cell Lung Chugai Pharmaceutical Co Ltd 2004-11-18 Solid tumours; Head and Neck Neoplasms; Ependymoma; Pancreatic Neoplasms; Glioblastoma; Breast Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Recombinant epidermal growth factor gel (Pavay Gene Pharmaceutical) Approved Guilin Huanuowei Gene Pharmaceutical Co Ltd 易孚 Mainland China Skin Ulcer; Burns Guilin Huanuowei Gene Pharmaceutical Co Ltd 2002-12-23 Skin Ulcer; Burns Details
Recombinant epidermal growth factor (Shanghai Haohai ) Approved Shanghai Haohai Biological Technology Co Ltd 康合素 Mainland China Burns Shanghai Haohai Biological Technology Co Ltd 2001-01-01 Burns Details
Recombinant epidermal growth factor (Center for Genetic Engineering and Biotechnology/Praxis Pharmaceuticals) Approved Center For Genetic Engineering And Biotechnology, Praxis Pharmaceuticals Heberprot-P Cuba Diabetic Foot null 2007-09-01 Diabetic Foot Details
Recombinant epidermal growth factor drop (Pavay Gene Pharmaceutical) Approved Guilin Huanuowei Gene Pharmaceutical Co Ltd 易贝 Mainland China Corneal Diseases Guilin Huanuowei Gene Pharmaceutical Co Ltd 2002-04-12 Corneal Diseases; Xerophthalmia Details
Recombinant epidermal growth factor biosimilar (Elea) r-hu-EGF Approved Elea Argentina Diabetic Foot; Burns Elea 2015-01-01 Diabetic Foot; Burns Details
Epidermal growth factor biosimilar (RAS Lifesciences) Approved Ras Lifesciences India Ras Lifesciences 2012-10-01 Details
Cetuximab biosimilar (CinnaGen) Approved Cinnagen Iran Colorectal Neoplasms Cinnagen 2017-01-01 Colorectal Neoplasms Details
Recombinant epidermal growth factor (Bharat Biotech) REGEN-D 60; REGEN-D 150 Approved Bharat Biotech International Ltd India Diabetic Foot; Burns Bharat Biotech International Ltd 2005-01-01 Diabetic Foot; Burns Details
Recombinant human EGF conjugated vaccine Approved Biotech Pharmaceuticals Co Ltd Carcinoma, Non-Small-Cell Lung Details
Mouse epidermal growth factor (Hangzhou Tianmushan Pharmaceutical) Approved Hangzhou Tianmushan Pharmaceutical Enterprise Co Ltd 一夫 Wounds and Injuries Details
Pyrotinib Maleate HTI-1001; SHR-1258; BLTN Approved 艾瑞妮 Mainland China Breast Neoplasms Jiangsu Hengrui Medicine Co Ltd 2018-08-12 Biliary Tract Neoplasms; Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Adenocarcinoma of Lung; Breast Neoplasms; Bile Duct Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Recombinant Human Epidermal Growth Factor Derivative (Shenzhen Wastin Genetech) rEGF Approved Shenzhen Watsin Genetech Ltd 金因肽, GeneTime Mainland China Wounds and Injuries Shenzhen Watsin Genetech Ltd 2001-01-01 Wounds and Injuries Details
Nimotuzumab TheraCIMh-R3; YMB-1000; OSAG-10; KI-0502; KI-0501; DE-766; h-R3; OSAG-101 Approved Center Of Molecular Immunology BIOMAb-EGFR, TheraCIM, 泰欣生, CIMAher, Theraloc Mainland China Nasopharyngeal Neoplasms Biotech Pharmaceuticals Co Ltd 2006-07-21 Head and Neck Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Nasopharyngeal Neoplasms; Pancreatic Neoplasms; Glioma; Carcinoma, Squamous Cell; Esophageal Squamous Cell Carcinoma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Olmutinib ZL-2303; HM-61713B; HM-61713; BI-1482694 Approved Hanmi Pharmaceutical Co Ltd Olita South Korea Carcinoma, Non-Small-Cell Lung Hanmi Pharmaceutical Co Ltd 2016-05-01 Carcinoma, Non-Small-Cell Lung Details
Mobocertinib TAK-788; AP-32788 Approved Ariad Pharmaceuticals Inc, Takeda Pharmaceutical Co Ltd EXKIVITY United States Carcinoma, Non-Small-Cell Lung Takeda Pharmaceuticals U.S.A. Inc 2021-09-15 Kidney Diseases; Hepatic Insufficiency; Carcinoma, Non-Small-Cell Lung Details
Alflutinib Mesylate AST-2818 Approved Shanghai Allist Pharmaceutical Technology Co Ltd 艾弗沙 Mainland China Carcinoma, Non-Small-Cell Lung Shanghai Allist Pharmaceutical Technology Co Ltd 2021-03-02 Carcinoma, Non-Small-Cell Lung Details
Dacomitinib PF-299; PF-804; PF-299804; PF-00299804; PF-00299804-3; PF-00299804-03 Approved Pfizer Inc Vizimpro Mainland China Carcinoma, Non-Small-Cell Lung Pfizer Europe Ma Eeig 2018-09-27 Solid tumours; Head and Neck Neoplasms; Neoplasms; Liver Diseases; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details
Lapatinib Ditosylate Hydrate GW-2016; GW-572016; GW-572016F Approved Novartis Pharma Ag, Glaxosmithkline Plc Tykerb/Tyverb, 泰立沙, Tykerb, Tyverb Mainland China Breast Neoplasms Glaxosmithkline Ag 2007-03-13 Solid tumours; Carcinoma, Renal Cell; Esophageal Neoplasms; Stomach Neoplasms; Squamous Cell Carcinoma of Head and Neck; Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Glioma; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Gastrointestinal Neoplasms; Uterine Cervical Neoplasms Details
Icotinib Hydrochloride BPI-2009H; BPI-2009C Approved Betta Pharmaceuticals Co Ltd 凯美纳, Conmana Mainland China Carcinoma, Non-Small-Cell Lung Betta Pharmaceuticals Co Ltd 2011-06-07 Stomach Neoplasms; Esophageal Neoplasms; Psoriasis; Nasopharyngeal Carcinoma; Esophageal adenocarcinoma; Brain metastases; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
Gefitinib ZD-1839 Approved Astrazeneca Pharmaceutical Co Ltd 易瑞沙, Iressa EU Carcinoma, Non-Small-Cell Lung Astrazeneca Ab 2002-07-05 Head and Neck Neoplasms; Carcinoma; Small Cell Lung Carcinoma; Glioblastoma; Mesothelioma; Prostatic Neoplasms; Breast Neoplasms; Brain Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details
Afatinib Dimaleate BIBW-2992; BIBW-2992-MA2 Approved C.H. Boehringer Sohn Ag & Co. Kg 吉泰瑞, Tovok, Giotrif, Gilotrif, Tomtovok Mainland China Carcinoma, Non-Small-Cell Lung Boehringer Ingelheim International Gmbh 2013-07-12 Head and Neck Neoplasms; Rhabdomyosarcoma; Squamous Cell Carcinoma of Head and Neck; Renal Insufficiency; Neoplasms; Neuroectodermal Tumors; Liver Diseases; Endometriosis; Breast Neoplasms; Urologic Neoplasms; Colorectal Neoplasms; Carcinoma, Squamous Cell; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Adenocarcinoma Details
Neratinib Maleate CAN-030; HKI-272; PF-0528767; WAY-179272; PB-272 Approved Pfizer Pharmaceuticals Ltd (China) Nerlynx, 贺俪安 Mainland China Breast Neoplasms Excella Gmbh & Co Kg 2017-07-17 Solid tumours; Glioblastoma; Breast Neoplasms; Hepatic Insufficiency; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Amivantamab JNJ-372; JNJ-61186372 Approved Janssen Global Services Llc, Genmab RYBREVANT EU Carcinoma, Non-Small-Cell Lung Janssen-Cilag International Nv 2021-05-21 Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Necitumumab LY-3012211; IMC-11F8 Approved Eli Lilly And Company Portrazza Japan Carcinoma, Non-Small-Cell Lung Nippon Kayaku Co Ltd 2015-11-24 Solid tumours; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung Details
Almonertinib Mesilate HS-10296 Approved Jiangsu Hansoh Pharmaceutical Group Co Ltd 阿美乐 Mainland China Carcinoma, Non-Small-Cell Lung Jiangsu Hansoh Pharmaceutical Group Co Ltd 2020-03-17 Liver Diseases; Carcinoma, Non-Small-Cell Lung Details
Panitumumab ABX-0303; E7.6.3; AMG-954; ABX-EGF; ABX-10221 Approved Amgen Inc Vectibix Japan Colorectal Neoplasms Takeda 2006-09-27 Solid tumours; Head and Neck Neoplasms; Rectal Neoplasms; Esophageal Neoplasms; Carcinoma; Carcinoma, Renal Cell; Pancreatic Neoplasms; Colonic Neoplasms; Prostatic Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Carcinoma, Squamous Cell; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Gastrointestinal Neoplasms Details
Nepidermin DWP-401 Approved Daewoong Pharmaceutical Co Ltd Easyef Egypt Alopecia; Diabetic Foot Daewoong Pharmaceutical Co Ltd 2001-01-01 Diabetic Foot; Alopecia; Dry Eye Syndromes Details
Brigatinib AP-26113 Approved Takeda Pharmaceutical Co Ltd, Ariad Alunbrig Japan Carcinoma, Non-Small-Cell Lung Takeda 2017-04-28 Solid tumours; Carcinoma; Myofibroma; Lymphoma, Large-Cell, Anaplastic; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Cetuximab sarotalocan RM-1929; ASP-1929 Approved Aspyrian Therapeutics Akalux Japan Head and Neck Neoplasms Rakuten Medical 2020-09-25 Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck Details
Osimertinib Mesylate AZD-9291; RDL94R2A16; AZD-9291 Mesylate; AZD9291 Approved Astrazeneca Pharmaceutical Co Ltd 泰瑞沙, Tagrisso Mainland China Carcinoma, Non-Small-Cell Lung Astrazeneca Ab 2015-11-13 Solid tumours; Carcinoma, Bronchogenic; Carcinoma; Thoracic Neoplasms; Bronchial Neoplasms; Lung Diseases; Respiratory Tract Neoplasms; Neoplasms, Nerve Tissue; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
Vandetanib AZD-6474; CH-331; ZD-6474 Approved Astrazeneca Pharmaceutical Co Ltd Zactima, Caprelsa Japan Medullary thyroid cancer (MTC) Astrazeneca Pharmaceutical Co Ltd 2011-04-06 Solid tumours; Multiple Myeloma; Mesothelioma; Breast Neoplasms; Medullary thyroid cancer (MTC); Prostatic Neoplasms; Colorectal Neoplasms; Carcinoma, Neuroendocrine; Thyroid Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Neoplasm Metastasis Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
MicroRNA encapsulated nanocells (EnGeneIC) Phase 2 Clinical Engeneic Mesothelioma Details
Recombinant human anti-EGFR mAB (Genrix Bio) GR-1401; UBP-1215 Phase 1 Clinical Shanghai Zhonghe Medicine Technology Co Ltd, Bioex Therapeutics Head and Neck Neoplasms; Solid tumours; Esophageal Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Cetuximab biosimilar (R-Pharm) RPH-002 Phase 3 Clinical R-Pharm Head and Neck Neoplasms; Pancreatic Neoplasms Details
D2C7-based immunotoxins (Duke University) D2C7-IT; scds-D2C7 -PE38KDEL; D2C7-(scdsFv)-PE38 KDEL Phase 1 Clinical Istari Oncology, Duke University Glioma Details
Nimotuzumab biosimilar (El Kendi Pharmaceuticals Manufacturing) Phase 3 Clinical El Kendi Pharmaceuticals Uterine Cervical Neoplasms Details
WSD-0922 WSD0922; WSD-0922 Phase 1 Clinical Vision Biological Tech (Hefei) Co Ltd Glioblastoma; Glioma Details
MCLA-129 MCLA-129 Phase 2 Clinical Merus Solid tumours; Head and Neck Neoplasms; Stomach Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
XZP-5809-TT1 XZP-5809-TT1; XZP-5809 Phase 2 Clinical Shandong Xuanzhu Pharmaceutical Technology Co Ltd Carcinoma, Non-Small-Cell Lung Details
Puvitinib Phase 1 Clinical Suzhou Teligene Ltd Solid tumours Details
ASP-0598 ASP-0598 Phase 2 Clinical Auration Biotech, Astellas Pharma Inc Ear Diseases; Tympanic Membrane Perforation Details
CM-93 CM-93 Phase 1 Clinical Shanghai Crimson Pharmaceutical Co Ltd Glioblastoma Details
Zorifertinib AZD-3759 Phase 3 Clinical Astrazeneca Plc Brain metastases; Carcinoma, Non-Small-Cell Lung Details
Depatuxizumab mafodotin ABT-414; ABT-414/806 Phase 3 Clinical Abbvie Inc Glioblastoma; Gliosarcoma; Carcinoma, Squamous Cell; Glioma; Carcinoma, Non-Small-Cell Lung Details
Anti-EGFR-IL-dox (Swiss Group for Clinical Cancer Research) Phase 2 Clinical Schweizerische Arbeitsgemeinschaft Für Klinische Krebsforschung Breast Neoplasms Details
AMX-3009 Maleate AMX-3009; AMX3009马来酸 Phase 1 Clinical Anrun Medicine Technology (Suzhou) Co Ltd Solid tumours; Stomach Neoplasms; Pancreatic Neoplasms; Breast Neoplasms Details
SGT-210 SGT-210 Phase 1 Clinical Sol Gel Technologies Pte Ltd Keratosis Details
Pemlimogene merolisbac (Aduro Biotech/Jannsen Biotech) ADU-214; JNJ-64041757 Phase 2 Clinical Aduro Biotech Ovarian Neoplasms; Adenocarcinoma of Lung; Carcinoma, Non-Small-Cell Lung Details
Varlitinib Ditosylate QBT-01; ARRY-543; SPS-4370; ASLAN-001; ARRY-334543 Phase 3 Clinical Array Biopharma Biliary Tract Neoplasms; Neoplasms; Pancreatic Neoplasms; Bile Duct Neoplasms Details
Anti-EGFR CAR T-cell therapy (Seattle Children's Hospital) EGFR-806 Phase 1 Clinical Seattle Children'S Hospital Central Nervous System Neoplasms Details
YK-029A YK-029A Phase 1 Clinical Hainan Yuekang Biomedicine Co Ltd Carcinoma, Non-Small-Cell Lung Details
MP-0274 DARPin-41; SPA-28; CME-114; CME-115; CME-118; CME-119; MP-0274 Phase 1 Clinical Molecular Partners Ag Neoplasms Details
Cetuximab biosimilar (Enzene Biosciences) Clinical Enzene Biosciences Carcinoma, Squamous Cell Details
BCA-101 BCA-101 Phase 1 Clinical Bicara Therapeutics Anus Neoplasms; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Carcinoma, Ovarian Epithelial; Neoplasms; Uveal melanoma; Chordoma; Colorectal Neoplasms; Carcinoma, Squamous Cell Details
Recombinant anti-InE monoclonal antibody Phase 1 Clinical Dingfu Biotarget Co Ltd Solid tumours Details
Anti-EGFR CAR-T cell therapy (Cellular Biomedicine Group) Phase 2 Clinical Cellular Biomedicine (Shanghai) Co Ltd, People'S Liberation Army General Hospital Military Service Neoplasms Details
TQB-3456 TQB-3456 Phase 1 Clinical Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd, Lianyungang Runzhong Pharmaceutical Co Ltd, Centaurus Biopharma Co Ltd Carcinoma, Non-Small-Cell Lung Details
Recombinant chimeric anti-EGFR monoclonal antibody (Qilu Pharmaceutical) QL-1105 Phase 1 Clinical Qilu Pharmaceutical Co Ltd Solid tumours Details
Betatinib TL-512 Phase 1 Clinical Aspedia Llc, Suzhou Teligene Ltd Carcinoma, Non-Small-Cell Lung Details
Nazartinib EGF-816; EGFRmut-TKI EGF816 Phase 2 Clinical Novartis Pharma Ag Triple Negative Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
Panitumumab-IRDye800CW (Stanford University) Phase 2 Clinical Stanford University Brain Neoplasms Details
QL1203 QL-1203 Phase 3 Clinical Qilu Pharmaceutical Co Ltd Colorectal Neoplasms Details
YZJ-0318 Maleate YZJ-0318 Maleate Phase 1 Clinical Shanghai Haiyan Trading Co Ltd, Yangtze River Pharmaceutical Group Jiangsu Haici Biological Pharmaceutical Co Ltd Carcinoma, Non-Small-Cell Lung Details
Mefatinib Phase 3 Clinical Suzhou Maitai Bio-Technology Co Ltd Solid tumours; Carcinoma, Non-Small-Cell Lung Details
C-005 C-005 Phase 1 Clinical Nanjing Galaxy Biopharma Co Ltd Carcinoma, Non-Small-Cell Lung Details
Epitinib Succinate HMPL-813 Phase 1 Clinical Hutchison Medipharma Ltd Solid tumours; Glioblastoma; Carcinoma, Non-Small-Cell Lung Details
Tomuzotuximab GT-MAB-5.2-GEX Phase 2 Clinical Glycotope Solid tumours; Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Stomach Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Cetuximab biosimilar (Guilin Sanjin) CDP-1 Phase 1 Clinical Guilin Sanjin Pharmaceutical Co Ltd, Dragonboat Biopharmaceutical Solid tumours; Colorectal Neoplasms Details
Sapitinib AZD-8931 Phase 2 Clinical Astrazeneca Pharmaceutical Co Ltd Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Neoplasm Metastasis Details
GC-1118A GC-1118; GC-1118A Phase 2 Clinical Korean Green Cross Corp Solid tumours; Stomach Neoplasms; Glioblastoma; Colorectal Neoplasms; Neoplasm Metastasis Details
Cetuximab biosimilar (AMPO Biotechnology) Phase 3 Clinical Ampo Biotechnology Inc Colorectal Neoplasms Details
Cetuximab biosimilar (Shanghai Zhangjiang Biotechnology) STI-001; CMAB-009 Phase 3 Clinical Shanghai Zhangjiang Biotechnology Co Ltd Colorectal Neoplasms Details
4-1BBz CD19-Her2tG (Seattle Children's Hospital) Phase 1 Clinical Seattle Children'S Hospital Neoplasms Details
TQB3804 TQB-3804 Phase 1 Clinical Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd Solid tumours; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
[111In] Panitumumab Phase 1 Clinical Stanford University Head and Neck Neoplasms Details
Epertinib S-222611 Phase 2 Clinical Shionogi & Co Ltd Neoplasms Details
Immunomodulatory progenitor cell therapy (Celixir) Phase 3 Clinical Celixir Endomyocardial Fibrosis; Cardiomyopathies Details
Cimaglermin alfa CGF-2 Phase 1 Clinical Ludwig Institute For Cancer Research Heart Failure Details
DBPR-112 DBPR-112 Phase 1 Clinical National Health Research Institutes Head and Neck Neoplasms; Lung Neoplasms Details
Recombinant anti-EGFR chimeric antibody (Harbin Pharmaceutical) Phase 1 Clinical Harbin Pharmaceutical Group Holding Co Ltd Colorectal Neoplasms Details
C225-ILS-DOX C225-ILs-dox Phase 2 Clinical Universitaetsspitals Basel Breast Neoplasms Details
HER-1 vaccine (Center of Molecular Immunology) HER1-ECD; HER1-VSSP; HER-1-ECD-VSSP Phase 2 Clinical Center Of Molecular Immunology Neoplasms Details
Losatuxizumab vedotin ABBV221; ABBV-221 Phase 1 Clinical Abbvie Inc Neoplasms Details
WTS-004 WTS-004 Phase 1 Clinical Hangzhou Wutong Tree Pharmaceutical Co Ltd Carcinoma, Non-Small-Cell Lung Details
BPI-15086 BPI-15000; BPI-15086 Phase 1 Clinical Betta Pharmaceuticals Co Ltd Carcinoma, Non-Small-Cell Lung Details
KSP-QRH-E3-IRDye800 Phase 1 Clinical University Of Michigan Cholangiocarcinoma Details
Antibody-drug nanocell conjugates (EnGeneIC) EGFR-EDV-RRM1; EGFR-EDV-PLK; EGFR-EDV-Dox Phase 1 Clinical Engeneic Glioblastoma Details
Cetuximab I-131 (Pacific Meinuoke) Clinical Jiangsu Pacific-Meinuoke Bio-Pharmaceutical Co Ltd Colorectal Neoplasms Details
ES-072 ES-072 Phase 1 Clinical Zhejiang Bosheng Pharmaceutical Co Ltd Carcinoma, Non-Small-Cell Lung Details
ABY-029 ABY-029 Phase 1 Clinical Dartmouth College, Affibody, Li-Cor Bioscience Glioma Details
EGFRvIII-CAR Phase 1 Clinical Duke University Medical Center Glioblastoma Details
AVID-100 AVID-100 Phase 2 Clinical Formation Biologics Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Breast Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung Details
SPH1188-11 SPH1188-11 Phase 1 Clinical Shanghai Pharmaceuticals Holding Co Ltd Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung Details
Autologous EGFR-CAR T cells (Bio-gene) Phase 1 Clinical Sun Yat-Sen University, Guangzhou Bio-Gene Technology Co Ltd Carcinoma, Non-Small-Cell Lung Details
Yinlitinib Phase 1 Clinical Hec Pharm Co Ltd Solid tumours Details
Cetuximab biosimilar (AlphaMab) KN-005 Phase 3 Clinical Suzhou Alphamab Co Ltd Head and Neck Neoplasms; Anus Neoplasms; Urinary Bladder Neoplasms; Colorectal Neoplasms Details
Double-deleted Vaccinia Virus Plus CD/ SMR JX-929; vvDD-CDSR Phase 1 Clinical Sillajen Liver Neoplasms; Squamous Cell Carcinoma of Head and Neck; Pancreatic Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Melanoma Details
Futuximab/Modotuximab Sym-004; 992-and-1024 Phase 3 Clinical Symphogen Solid tumours; Carcinoma; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms Details
Simotinib Hydrochloride AL-6802; SIM-6802 Phase 1 Clinical Jiangsu Xiansheng Pharmaceutical Co Ltd, Advenchen Laboratories Colonic Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Entinostat/Erlotinib Hydrochloride Phase 2 Clinical Colorado State University Foundation, Syndax Carcinoma, Non-Small-Cell Lung Details
PLB-1004 PLB-1004 Phase 1 Clinical Beijing Anshi Biotechnology Co Ltd Carcinoma, Non-Small-Cell Lung Details
ZSP0391 ZSP-0391 Phase 1 Clinical Wuxi Apptec Co Ltd, Guangdong Zhongsheng Pharmaceutical Co Ltd Carcinoma, Non-Small-Cell Lung Details
Sirotinib Maleate XZP-5491 Phase 1 Clinical Shandong Xuanzhu Pharmaceutical Technology Co Ltd Stomach Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung Details
ZZ-06 ZZ-06 Phase 1 Clinical Changchun Intellicrown Pharmaceutical Co Ltd Solid tumours Details
Humanized anti-EGFR monoclonal antibody (Hualan Biological Engineering/Henan shengming biotechnology) Phase 2 Clinical Henan Shengming Biotechnology Research Institute Co Ltd, Hualan Genetic Engineering Co Ltd Colorectal Neoplasms Details
BB-101 (Blue Blood Biotech/National Cheng Kung University) BB-101 Phase 1 Clinical National Cheng Kung University, Blue Blood Biotech Corp Diabetic Foot Details
NRC-2694 NRC-2694; NRC-2694A; NRC-2694-A Phase 2 Clinical Natco Carcinoma, Squamous Cell Details
Tesevatinib KD-019; KD-020; XL-647; EXEL-7647 Phase 3 Clinical Exelixis Inc Glioblastoma; Breast Neoplasms; Brain Neoplasms; Polycystic Kidney, Autosomal Dominant; Brain metastases; Carcinoma, Non-Small-Cell Lung; Polycystic Kidney, Autosomal Recessive; Neoplasm Metastasis Details
Selatinib Ditosilate QLNC-120 Phase 2 Clinical Qilu Antibiotics (Linyi) Pharmaceutical Co Ltd, Qilu Pharmaceutical Co Ltd Stomach Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details
PB-357 PB-357 Phase 1 Clinical Pfizer Inc Neoplasms Details
BBT-176 BBT-176 Phase 2 Clinical Bridge Biotherapeutics Carcinoma, Non-Small-Cell Lung Details
Neptinib Di-P-methylbenzenesulfonate Phase 1 Clinical Shenzhen Neptunus Pharmaceutical Research Institute Co Ltd Stomach Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
JRF-103 JRF103; JRF-103 Phase 2 Clinical Shenzhen Jinrui Foundation Biotechnology Co Ltd Solid tumours Details
Recombinant anti-EGFR monoclonal antibody (Humanwell Healthcare) Phase 1 Clinical Humanwell Healthcare (Group) Co Ltd Colorectal Neoplasms Details
E-EDV-D682 PNU-15982; E-EDV-D682; EGFR-EDV-PNU-15982 Phase 2 Clinical Engeneic Pancreatic Neoplasms Details
MM-151 MM-151 Phase 2 Clinical Merrimack Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Allitinib Tosylate AST-6; ALS-1306; AST-1306 Phase 2 Clinical Shanghai Allist Pharmaceutical Technology Co Ltd Breast Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Cetuximab biobetter (Mabtech/Sorrento) STI-001 Phase 3 Clinical Taizhou Maibo Taike Biotechnology Co Ltd, Shanghai Biomabs Pharmaceuticals Co Ltd Colorectal Neoplasms Details
Recombinant human anti-EGFR mAb (Serum Biotechnology) SY-101 Phase 2 Clinical Institute Of Bioengineering Chinese Academy Of Military Medical Sciences, Shanghai Serum Bio-Technology Co Ltd Solid tumours; Colorectal Neoplasms Details
Anti-EGFR CAR-T cell therapy (Beijing Pregene) Phase 2 Clinical Shenzhen Prekin Biopharmaceutical Co Ltd Colorectal Neoplasms Details
M-1231 M-1231 Phase 1 Clinical Emd Serono Research & Development Institute Inc, Merck Serono Solid tumours; Esophageal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Recombinant anti-EGFR chimeric monoclonal antibody (Shanghai CP Guojian) CPGJ-602; 602; CPGJ602; CPGJ 602 Phase 2 Clinical Shanghai Cp Guojian Pharmaceutical Co Ltd Colorectal Neoplasms Details
Recombinant chimeric anti-EGFR monoclonal antibody (Zhejiang Xinwei Shengke Biotechnology) Phase 1 Clinical Zhejiang Xinweishengke Biotechnology Co Ltd Esophageal Neoplasms Details
Cetuximab biosimilar (Kelun Group) KLA140; KL-A140 Phase 3 Clinical Sichuan Kelun Pharmaceutical Co Ltd Colorectal Neoplasms Details
TQ-B3395 TQ-B3395; TQ-B-3395 Phase 1 Clinical Centaurus Biopharma Co Ltd, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd Esophageal Neoplasms; Breast Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung Details
[89Zr]Panitumumab (University of Alabama at Birmingham) Phase 2 Clinical University Of Alabama At Birmingham Colonic Neoplasms Details
LY-01010 LY-01010 Phase 1 Clinical Luye Pharma Group Ltd Breast Neoplasms Details
KY-1701 KY-1701 Phase 1 Clinical Jiangsu Kanion Pharmaceutical Co Ltd Breast Neoplasms Details
BB-401 BB-401 Phase 2 Clinical Benitec Biopharma Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck Details
BPI-361175 BPI-361175 Phase 1 Clinical Betta Pharmaceuticals Co Ltd Carcinoma, Non-Small-Cell Lung Details
Hemay-020 Hemay-020 Phase 1 Clinical Tianjin Hemay Pharmaceutical Co Ltd, Hainan General Sanyang Pharmaceutical Co Ltd Solid tumours; Head and Neck Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Serclutamab talirine ABBV-321 Phase 1 Clinical Abbvie Inc Neoplasms Details
JFAN-1001 JFAN-1001 Phase 2 Clinical Zhejiang Jianfeng Pharmaceutical Macutical Holdings Carcinoma, Non-Small-Cell Lung Details
FCN-411 FCN-411 Phase 1 Clinical Shanghai Fosun Pharmaceutical (Group) Co Ltd Carcinoma, Non-Small-Cell Lung Details
Doxitinib mesylate Phase 2 Clinical Henan Real Biotechnology Co Ltd Carcinoma, Non-Small-Cell Lung Details
Lifirafenib BGB-283; BeiGene-283 Phase 2 Clinical Beigene Ltd Solid tumours Details
EGFR IL12 CART Phase 1 Clinical Shenzhen Prekin Biopharmaceutical Co Ltd Colorectal Neoplasms Details
HA121-28 HA121-28; SYHA121-28 Phase 3 Clinical Cspc Pharmaceutical Technology (Shijiazhuang) Co Ltd Solid tumours; Biliary Tract Neoplasms; Medullary thyroid cancer (MTC); Bile Duct Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Olafertinib CK-101; RX-518; CS-2481; EGFR-IN-3 Phase 3 Clinical Suzhou Neupharma Co Ltd Lung Diseases; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
AP-L1898 AP-L1898; JS111 Phase 2 Clinical Wigen Biomedicine technology (Shanghai) Co Ltd, Shanghai Junshi Biosciences Co Ltd, Suzhou Junjing Biomedical Technology Co Ltd Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
FHND-9041 FHND-9041 Phase 3 Clinical Jiangsu Chia Tai Fenghai Pharmaceutical Co Ltd Carcinoma, Non-Small-Cell Lung Details
CART-EGFR-IL13Ra2 CART-EGFR-IL13Ra2; CAR-T-EGFR-IL-13-Ra-2 Phase 1 Clinical University Of Pennsylvania Glioblastoma Details
BNA-035 BNA-035 Phase 1 Clinical Binacea Pharma Inc Solid tumours Details
EG-007 EG-007 Phase 3 Clinical Evergreen Therapeutics Inc Endometrial Neoplasms Details
SI-B001 SI-B001 Phase 3 Clinical Sichuan Baili Pharmaceutical Co Ltd Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Neoplasms, Glandular and Epithelial; Triple Negative Breast Neoplasms; Digestive System Neoplasms; Colorectal Neoplasms; Esophageal Squamous Cell Carcinoma; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung Details
JMT101 JMT-101 Phase 3 Clinical Shanghai Jinmante Biological Technology Co Ltd Solid tumours; Carcinoma, Non-Small-Cell Lung Details
Lazertinib GNS-1480; JNJ-1937; YH-25448; JNJ-73841937 Phase 3 Clinical Genosco Hepatic Insufficiency; Carcinoma, Non-Small-Cell Lung Details
Anti-CTLA-4/PD-1 expressing EGFR-CAR-T Phase 2 Clinical Shanghai Cell Therapy Research Institute Solid tumours Details
Anti-EGFR-bispecific antibody armed activated T-cell therapy (Memorial Sloan Kettering Cancer Center) Phase 1 Clinical Memorial Sloan Kettering Cancer Center Pancreatic Neoplasms Details
Durvalumab/Gefitinib Phase 2 Clinical Medimmune Carcinoma, Non-Small-Cell Lung Details
SKLB-1028 SKLB-1028 Phase 3 Clinical Sichuan University, CSPC Pharmaceutical Group Ltd Solid tumours; Leukemia, Promyelocytic, Acute; Leukemia, Myeloid, Acute Details
SMET-12 SMET-12 Phase 1 Clinical Zhejiang Shimai Pharmaceutical Co Ltd Solid tumours Details
Anti-CD3/anti-EGFR -activated T cells (Barbara Ann Karmanos Cancer Institute) Phase 2 Clinical Barbara Ann Karmanos Cancer Institute, University Of Virginia Glioblastoma; Pancreatic Neoplasms Details
CKD-702 Phase 1 Clinical Chong Kun Dang Pharmaceutical Corp Carcinoma, Non-Small-Cell Lung Details
AFM-24 AFM-24 Phase 2 Clinical Affimed Solid tumours; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details
Cetuximab biosimilar (Shanghai Henlius Biotech) HLX-05; JZB-29; JZB-28 Phase 1 Clinical Shanghai Henlius Biotech Co Ltd Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms Details
LR-004 LR-004; SYN-004 Phase 2 Clinical Lonn Ryonn Pharma Ltd Solid tumours; Carcinoma; Lymphoma, Large B-Cell, Diffuse; Graft vs Host Disease; Colorectal Neoplasms Details
Petosemtamab MCLA-158 Phase 1 Clinical Merus Colorectal Neoplasms Details
TAS-6417 CLN-081; TAS-6417 Phase 2 Clinical Carcinoma, Non-Small-Cell Lung Details
XZP-5209 XZP-5209 Phase 1 Clinical Xuanzhu (Shijiazhuang) Biotechnology Co Ltd Carcinoma, Non-Small-Cell Lung Details
TY-9591 TY-9591 Phase 2 Clinical Zhejiang Tongkang Medicine Co Ltd Meningeal Neoplasms; Brain metastases; Carcinoma, Non-Small-Cell Lung Details
HLX-35 HLX-35 Phase 1 Clinical Shanghai Henlius Biologics Co Ltd Solid tumours Details
BEBT-109 BEBT-109 Phase 2 Clinical Carcinoma, Non-Small-Cell Lung Details
MRG003 MRG-003 Phase 2 Clinical Shanghai Miracogen Inc Biliary Tract Neoplasms; Solid tumours; Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Nasopharyngeal Carcinoma; Colorectal Neoplasms; Bile Duct Neoplasms; Carcinoma, Non-Small-Cell Lung Details
ABBV-637 ABBV-637 Phase 1 Clinical Abbvie Inc Solid tumours; Carcinoma, Non-Small-Cell Lung Details
BAY-2927088 BAY-2927088; BAY2927088 Phase 1 Clinical Bayer Healthcare Company Ltd, Bayer Ag Carcinoma, Non-Small-Cell Lung Details
BDTX-1535 BDTX-1535 Phase 1 Clinical Black Diamond Therapeutics Glioblastoma; Carcinoma, Non-Small-Cell Lung Details
ZN-e4 ZN-e4; KP-673 Phase 2 Clinical Zentalis Pharmaceuticals, Zeno Pharma Carcinoma, Non-Small-Cell Lung Details
Sutetinib Maleate Phase 2 Clinical Jiangsu Maidu Pharmaceutical R & D Co Ltd, Jiangsu Suzhong Pharma Group Co Ltd Solid tumours; Carcinoma, Non-Small-Cell Lung Details
FWD1509 MsOH FWD1509 MsOH Phase 2 Clinical Shenzhen Forward Pharmaceuticals Co Ltd Carcinoma, Non-Small-Cell Lung Details
BL-B01D1 Phase 1 Clinical Sichuan Baili Pharmaceutical Co Ltd Neoplasms, Fibroepithelial; Solid tumours; Digestive System Neoplasms; Urologic Neoplasms Details
Demupitamab SCT-200 Phase 2 Clinical SinoCelltech Ltd Solid tumours; Head and Neck Neoplasms; Biliary Tract Neoplasms; Ovarian Neoplasms; Carcinoma; Stomach Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Colorectal Neoplasms; Gallbladder Neoplasms; Esophageal Squamous Cell Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung Details
CX-904 CX-904 Phase 1 Clinical Amgen Inc, Cytomx Therapeutics Neoplasms Details
REGN-7075 REGN-7075 Phase 2 Clinical Regeneron Pharmaceuticals Solid tumours Details
TAK-186 EGFR x CD3 COBRA; MVC-101; TAK-186 Phase 2 Clinical Takeda Pharmaceutical Co Ltd Solid tumours; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
BC-3448 BC-3448; BC3448 Phase 1 Clinical Wuxi Zhikang Hongyi Biological Technology Co Ltd Solid tumours Details
Sunvozertinib DZD-9008 Phase 2 Clinical Dizal (Jiangsu) Pharmaceutical Co Ltd Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Carcinoma, Non-Small-Cell Lung Details
Pirotinib Hydrochloride KBP-5209 Phase 2 Clinical Shandong Xuanzhu Pharmaceutical Technology Co Ltd Solid tumours; Breast Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Bafisontamab EMB-01 Phase 2 Clinical Shanghai Epimab Biotherapeutics, Inc Biliary Tract Neoplasms; Liver Neoplasms; Stomach Neoplasms; Carcinoid Tumor; Digestive System Neoplasms; Colorectal Neoplasms; Carcinoma, Hepatocellular; Neoplasm Metastasis; Gastrointestinal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
ERAS-801 ERAS-801 Phase 1 Clinical Regents Of The University Of California Glioblastoma Details
BB-1705 BB-1705 Phase 2 Clinical Baili Sikang Biomedicine (Hangzhou) Co Ltd Solid tumours; Neoplasms Details
BDTX-189 BDTX-189 Phase 2 Clinical Black Diamond Therapeutics Solid tumours Details
Kenaitinib MED-1007; TL-007 Phase 2 Clinical Jiangsu Maidu Pharmaceutical R & D Co Ltd Lymphoma, B-Cell; Lymphoma, Mantle-Cell; Brain metastases; Carcinoma, Non-Small-Cell Lung Details
Imgatuzumab GA-201; R-7160; RG-7160; RO-5083945 Phase 2 Clinical Glycart Biotechnology Head and Neck Neoplasms; Colorectal Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung Details
BLU-701 BLU-701; BLU 701 Phase 2 Clinical Blueprint Medicines Carcinoma, Bronchogenic; Carcinoma; Thoracic Neoplasms; Bronchial Neoplasms; Lung Diseases; Respiratory Tract Neoplasms; Neoplasms, Nerve Tissue; Lung Neoplasms; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung Details
Larotinib Mesylate Z-650 Phase 3 Clinical Guangdong Dongyangguang Pharmaceutical Co Ltd Solid tumours; Esophageal Neoplasms; Pancreatic Neoplasms; Esophageal Squamous Cell Carcinoma Details
Pimurutamab HLX-07 Phase 2 Clinical Shanghai Henlius Biotech Co Ltd Solid tumours; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Stomach Neoplasms; Esophageal Squamous Cell Carcinoma; Carcinoma, Squamous Cell; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
BLU-945 BLU-945 Phase 2 Clinical Blueprint Medicines Carcinoma, Bronchogenic; Thoracic Neoplasms; Carcinoma; Bronchial Neoplasms; Lung Diseases; Respiratory Tract Neoplasms; Neoplasms, Nerve Tissue; Lung Neoplasms; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung Details

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