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Nectin-4

Nectin-4 Molecule Information

Name:Nectin-4
Target Synonym:LNIR,Nectin cell adhesion molecule 4,PVRL4,Ig superfamily receptor LNIR,Poliovirus receptor-related protein 4,NECTIN4,Poliovirus Receptor-Related 4,Nectin-4,Nectin 4,PRR4,EDSS1
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Approved

Nectin-4 Protein Product ListCompare or Buy

Nectin-4 Part of Bioactivity data

NE4-M5257-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Mouse Nectin-4, Fc Tag (Cat. No. NE4-M5257) on Protein A Biosensor, can bind Human Nectin-1, His Tag (Cat. No. PV1-H5223) with an affinity constant of 278 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested)

NE4-H5255-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human Nectin-4, Fc Tag (Cat. No. NE4-H5255) on Protein A Biosensor, can bind Human Nectin-1, His Tag (Cat. No. PV1-H5223) with an affinity constant of 0.263 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Nectin-4 Customer Reviews

Nectin-4 Molecule Synonym Name

NECTIN4,LNIR, PRR4, PVRL4

Nectin-4 Molecule Background

Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. Nectins are cell adhesion molecules that play a key role in various biological processes such as polarity, proliferation, differentiation and migration, for epithelial, endothelial, immune and neuronal cells, during development and adult life. Nectin-4 is a tumor-associated antigen in 50%, 49% and 86%o of breast, ovarian and lung carcinomas, respectively, mostly on tumors of bad prognosis. Its expression is not detected in the corresponding normal tissues.

Nectin-4 References

Nectin-4 Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Enfortumab vedotin AGS-M6; AGS-22ME; ASG-22CE; ASG-22ME; AGS-22M6E; ASG-22M6E; AGS-22C3; DLE8519RWM Approved Agensys, Seattle Genetics Padcev United States Urologic Neoplasms; Urinary Bladder Neoplasms s:19:"Astellas Pharma Inc"; 2019-12-18 Solid tumours; Kidney Neoplasms; Carcinoma; Carcinoma, Transitional Cell; Urinary Bladder Neoplasms; Urethral Neoplasms; Ureteral Neoplasms; Urologic Neoplasms Details

Nectin-4 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Nectin4/FAP-targeted CAR-T cell therapy (The Sixth Affiliated Hospital of Wenzhou Medical University) Phase 1 Clinical Wenzhou Medical University Neoplasms Details

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