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Your Position: Home > Nectin-4

Nectin-4

Brief Information

Name:Nectin-4
Target Synonym:PRR4,LNIR,Nectin cell adhesion molecule 4,PVRL4,Ig superfamily receptor LNIR,Poliovirus receptor-related protein 4,NECTIN4,Poliovirus Receptor-Related 4,Nectin-4,Nectin 4,EDSS1
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

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Part of Bioactivity data

NE4-HF2H3-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

2e5 of anti-Nectin-4 CAR-293 cells were stained with 100 μL of 10 μg/mL of FITC-Labeled Human Nectin-4, His Tag (Cat. No. NE4-HF2H3) and negative control protein respectively, FITC signal was used to evaluate the binding activity (QC tested).

NE4-C52H4-SPR
Human_FcRn_Heterodimer_Protein_SPR

Mouse Anti-Nectin-4 Antibody (Mouse IgG1) captured on CM5 chip via anti-mouse antibodies surface can bind Cynomolgus Nectin-4, His Tag (Cat. No. NE4-C52H4) with an affinity constant of 824 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

NE4-H52H3-SPR
Human_FcRn_Heterodimer_Protein_SPR

Mouse Anti-Nectin-4 Antibody (Mouse IgG1) captured on CM5 chip via anti-mouse antibodies surface can bind Human Nectin-4, His Tag (Cat. No. NE4-H52H3) with an affinity constant of 58.2 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

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Synonym Name

NECTIN4,LNIR, PRR4, PVRL4

Background

Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. Nectins are cell adhesion molecules that play a key role in various biological processes such as polarity, proliferation, differentiation and migration, for epithelial, endothelial, immune and neuronal cells, during development and adult life. Nectin-4 is a tumor-associated antigen in 50%, 49% and 86%o of breast, ovarian and lung carcinomas, respectively, mostly on tumors of bad prognosis. Its expression is not detected in the corresponding normal tissues.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Enfortumab vedotin AGS-22C3E; ASG-22CE; AGS-22ME; AGS-22C3; AGS-M6; ASG-22M6E; DLE8519RWM; ASG-22ME; AGS-22M6E Approved Agensys, Seattle Genetics Padcev Canada Urinary Bladder Neoplasms Astellas Pharma Us Inc 2019-12-18 Kidney Neoplasms; Solid tumours; Carcinoma; Carcinoma, Transitional Cell; Urinary Bladder Neoplasms; Urethral Neoplasms; Carcinoma in Situ; Ureteral Neoplasms; Urologic Neoplasms Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Nectin4/FAP-targeted CAR-T cell therapy (The Sixth Affiliated Hospital of Wenzhou Medical University) Phase 1 Clinical Wenzhou Medical University Neoplasms Details
BT-8009 BT-8009 Phase 2 Clinical Bicycle Tx Ltd Ovarian Neoplasms; Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Carcinoma, Non-Small-Cell Lung Details
BT-7480 BT-7480 Phase 2 Clinical Bicycle Therapeutics Solid tumours; Neoplasms Details
9MW2821 9MW2821; 9-MW2821; 9-MW-2821; 9MW-2821 Phase 2 Clinical Mabwell (Shanghai) Bioscience Co Ltd Solid tumours Details
SBT-6290 SBT-6290 Phase 2 Clinical Silverback Therapeutics Inc Solid tumours; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Transitional Cell; Triple Negative Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details

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