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Nectin-4

Brief Information

Name:Nectin-4
Target Synonym:LNIR,Nectin cell adhesion molecule 4,PVRL4,Ig superfamily receptor LNIR,Poliovirus receptor-related protein 4,NECTIN4,Poliovirus Receptor-Related 4,Nectin-4,Nectin 4,PRR4,EDSS1
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Approved

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Part of Bioactivity data

NE4-C52H4-SPR
Human_FcRn_Heterodimer_Protein_SPR

Mouse Anti-Nectin-4 Antibody (Mouse IgG1) captured on CM5 chip via anti-mouse antibodies surface can bind Cynomolgus Nectin-4, His Tag (Cat. No. NE4-C52H4) with an affinity constant of 824 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

NE4-H52H3-SPR
Human_FcRn_Heterodimer_Protein_SPR

Mouse Anti-Nectin-4 Antibody (Mouse IgG1) captured on CM5 chip via anti-mouse antibodies surface can bind Human Nectin-4, His Tag (Cat. No. NE4-H52H3) with an affinity constant of 58.2 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

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Synonym Name

NECTIN4,LNIR, PRR4, PVRL4

Background

Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. Nectins are cell adhesion molecules that play a key role in various biological processes such as polarity, proliferation, differentiation and migration, for epithelial, endothelial, immune and neuronal cells, during development and adult life. Nectin-4 is a tumor-associated antigen in 50%, 49% and 86%o of breast, ovarian and lung carcinomas, respectively, mostly on tumors of bad prognosis. Its expression is not detected in the corresponding normal tissues.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Enfortumab vedotin AGS-M6; AGS-22ME; ASG-22CE; ASG-22ME; AGS-22M6E; ASG-22M6E; AGS-22C3; DLE8519RWM Approved Agensys, Seattle Genetics Padcev United States Urothelial Carcinoma Astellas Pharma Us Inc 2019-12-18 Solid tumours; Kidney Neoplasms; Carcinoma; Carcinoma, Transitional Cell; Neoplasms; Urinary Bladder Neoplasms; Urethral Neoplasms; Carcinoma in Situ; Urologic Neoplasms; Ureteral Neoplasms Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Nectin4/FAP-targeted CAR-T cell therapy (The Sixth Affiliated Hospital of Wenzhou Medical University) Phase 1 Clinical Wenzhou Medical University Neoplasms Details

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