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Mesothelin

Mesothelin Molecule Information

Name:Mesothelin
Target Synonym:MPF;Pre-pro-megakaryocyte-potentiating factor;CAK1 antigen;Mesothelin;Megakaryocyte-potentiating factor;MSLN;Mesothelin, cleaved form
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:15
Lastest Research Phase:Phase ?

Mesothelin Part of Bioactivity data

MSN-HF25x-Cell-based assay
Evaluation of CAR expression

293 cells were transfected with anti-MSLN-scFv and RFP tag. 2e5 of the cells were stained with B. FITC-Labeled Human Mesothelin (296-580), Fc Tag (Cat. No. MSN-HF25x, 0.3 µg/ml) and C. FITC-labeled protein control. A. Non-transfected 293 cells and C. FITC-labeled protein control were used as negative control. RFP was used to evaluate CAR (anti-MSLN-scFv) expression and FITC was used to evaluate the binding activity of FITC-Labeled Human Mesothelin (296-580), Fc Tag (Cat. No. MSN-HF25x).

MSN-HR2P4-SPR
Human_FcRn_Heterodimer_Protein_SPR

can bind Human MS4A1 / CD20 Full Length Protein, His Tag (Cat. No. CD0-H55Ha)with an affinity constant of 1.21 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

MSN-HG2P4-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-human MSLN MAb (chimeric mouse-human IgG1) captured on CM5 chip via Anti-human IgG Fc antibodies surface, can bind GFP Fusion Human Mesothelin (296-580), His Tag (Cat. No. MSN-HG2P4) with an affinity constant of 0.542 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Mesothelin Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
MSN-C52H6 Cynomolgus Cynomolgus Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)
MSN-C52H6-structure
MSN-C52H6-sds
MSN-C52H6-elisa_1
MSN-M52H3 Mouse Mouse Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
MSN-M52H3-structure
MSN-M52H3-sds
MSN-M52H3-elisa_1
MSN-HF25x Human FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-HF25x-structure
MSN-HF25x-sds
MSN-HF25x-elisa_1
MSN-HR2P4 Human RFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HR2P4-structure
MSN-HR2P4-sds
MSN-HR2P4-elisa_1
MSN-HR2P4-elisa_2
MSN-HG2P4 Human GFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HG2P4-structure
MSN-HG2P4-sds
MSN-HG2P4-elisa_1
MSN-HG2P4-elisa_2
MSN-HP223 Human PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HP223-structure
MSN-HF223 Human FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HF223-structure
MSN-HF223-sds
MSN-HF223-elisa_1
MSN-HF253 Human FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-HF253-structure
MSN-HF253-sds
MSN-HF253-elisa_1
MSN-H82F6 Human Biotinylated Human Mesothelin / MSLN (296-580) Protein, Fc,Avitag™
MSN-H82F6-structure
MSN-H82F6-sds
MSN-H82F6-elisa_1
MSN-H522a Human Human Mesothelin / MSLN (296-580) Protein, His Tag, low endotoxin
MSN-H522a-structure
MSN-H522a-sds
MSN-H522a-elisa_1
MSN-H5253 Human Human Mesothelin / MSLN (296-580) Protein, Fc Tag (HPLC verified)
MSN-H5253-structure
MSN-H5253-sds
MSN-H5253-hplc
MSN-H5253-elisa_1
MSN-H82E9 Human Biotinylated Human Mesothelin / MSLN (296-580) Protein, His,Avitag™
MSN-H82E9-structure
MSN-H82E9-sds
MSN-H82E9-elisa_1
MSN-H826x Human Biotinylated Human Mesothelin / MSLN (296-580), Fc Tag, ultra sensitivity (primary amine labeling)
MSN-H826x-structure
MSN-H826x-sds
MSN-H826x-elisa_1
MSN-H8223 Human Biotinylated Human Mesothelin / MSLN (296-580) Protein, His Tag, ultra sensitivity (primary amine labeling)
MSN-H8223-structure
MSN-H8223-sds
MSN-H8223-elisa_1
MSN-H526x Human Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-H526x-structure
MSN-H526x-sds
MSN-H526x-elisa_1
MSN-H5223 Human Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-H5223-structure
MSN-H5223-sds
MSN-H5223-elisa_1
MSN-H5223-elisa_2
MSN-H5222 Human Human Mesothelin / MSLN (37-286) Protein, His Tag
MSN-H5222-structure
MSN-H5222-sds

Mesothelin Molecule Synonym Name

MSLN,Mesothelin,MPF

Mesothelin Molecule Background

Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

Mesothelin References

Mesothelin Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
RG-7600 DMOT-4039A; RG-7600 Phase Ⅰ Genentech Ovarian cancer, Pancreatic cancer Details
CART-meso CART-meso Phase Ⅰ University of Pennsylvania, Novartis Mesothelioma, Ovarian cancer, Pancreatic cancer Details
MCY-M11 MCY-M11 Phase Ⅰ MaxCyte Pleural mesothelioma, Ovarian cancer Details
CAT-5001 CAT-5001 Phase Ⅱ National Cancer Institute, AstraZeneca Mesothelioma, Ovarian cancer, Pancreatic cancer Details
Anti-mesothelin CAR T cell therapy (Shanghai GeneChem) Phase Ⅰ Shanghai GeneChem Pancreatic cancer Details
anti-mesothelin thorium-227 labeled antibody chelator conjugate BAY-2287411 Phase Ⅰ Bayer Solid tumours Details
KD-021 (Nanjing KAEDI Biotech) KD-021 Phase Ⅰ Nanjing KAEDI Biotech Solid tumours Details
Amatuximab MORAb-009; MORAB-009-006 Phase Ⅱ National Cancer Institute, Morphotek Mesothelioma, Solid tumours, Pancreatic cancer Details
Anetumab ravtansine BAY-94-9343; BAY-94-9343-SPDB-DM4; Anti-mesothelin antibody-drug conjugate BAY 94-9343 Phase Ⅱ Bayer, MorphoSys Non small cell lung cancer (NSCLC), Mesothelioma, Solid tumours Details
Anti-CTLA-4 and PD-1 CAR-T cell therapy (Shanghai Cell Therapy Research Institute) Phase Ⅱ Shanghai Cell Therapy Research Institute Solid tumours Details
LMB-100 LMB-100; RG-7787; RO-6927005 Phase Ⅱ Roche, National Cancer Institute, Selecta Biosciences Mesothelioma Details
iCasp9M28z iCasp9M28z Phase Ⅰ Memorial Sloan-Kettering Cancer Center Pleural mesothelioma, Mesothelioma, Breast cancer, Lung cancer, Metastatic cancer Details
BMS-986148 BMS-986148 Phase Ⅱ Bristol-Myers Squibb Solid tumours Details
RNA-Meso-CIR-T RNA-Meso-CIR-T Phase Ⅰ University of Pennsylvania, Novartis Mesothelioma Details
Anti-mesothelin CAR T-cell therapy (Marino Biotechnology) Phase Ⅰ Marino Biotechnology Cancer Details

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