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TROP-2

TROP-2 Molecule Information

Name:Tumor-associated calcium signal transducer 2
Target Synonym:TROP2;GA733-1;M1S1;TACSTD2;Cell surface glycoprotein Trop-2;Membrane component chromosome 1 surface marker 1;Pancreatic carcinoma marker protein GA733-1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:BLA ??

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TROP-2 Part of Bioactivity data

TR2-R52H3-MALS-HPLC
Rhesus macaque TROP-2, His Tag (Cat. No. ) MALS images

The purity of Rhesus macaque TROP-2, His Tag (Cat. No. TR2-R52H3) was more than 85% and the molecular weight of this protein is around 35-45 kDa verified by SEC-MALS.

  • Background
    TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.
  • References
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

    TR2-H5223-ELISA
    Human TROP-2, His TagHuman TROP-2, His Tag (Cat. No. TR2-H5223) ELISA bioactivity

    Immobilized Human TROP-2, His Tag (Cat. No. TR2-H5223) at 1 μg/mL (100 μL/well) can bind Monoclonal anti-TROP-2 antibody, Human IgG1 with a linear range of 0.006-0.6 μg/mL (Routinely tested).

TROP-2 Customer Reviews

TROP-2 Molecule Synonym Name

TACSTD2,GA733-1,M1S1,TROP2

TROP-2 Molecule Background

TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.

TROP-2 References

TROP-2 Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Sacituzumab govitecan IMMU-132; TROP-2-SN-38,IMMU132; TROP2SN38 Approved Immunomedics TRODELVY fda IMMUNOMEDICS INC 2020-04-22 Triple negative breast cancer Details

TROP-2 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
111In-IMP-288 111In-IMP-288; [111In]IMP-288 Phase Ⅱ Immunomedics Cancer Details
SKB-264 SKB-264 Phase Ⅱ Kelun Pharmaceutical Solid tumours Details
BAT8003 BAT-8003,BAT8003 Phase Ⅰ Bio-Thera Solutions Gastric cancer, Breast cancer Details
DAC-002 DAC-002 Phase Ⅰ Hangzhou DAC Biotech Triple negative breast cancer, Small cell lung cancer (SCLC), Non small cell lung cancer (NSCLC), Pancreatic cancer Details
DS-1062 DS-1062a; DS-1062 Phase Ⅱ Daiichi Sankyo Non small cell lung cancer (NSCLC) Details

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