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TROP-2 Molecule Information

Name:Tumor-associated calcium signal transducer 2
Target Synonym:TROP2;GA733-1;M1S1;TACSTD2;Cell surface glycoprotein Trop-2;Membrane component chromosome 1 surface marker 1;Pancreatic carcinoma marker protein GA733-1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:BLA ??

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Cat. No. Species Product Description Structure Purity Feature
TR2-M52H6 Mouse Mouse TROP-2 / TACSTD2 Protein, His Tag
TR2-H5253 Human Human TROP-2 / TACSTD2 Protein, Fc Tag
TR2-H82E5 Human Biotinylated Human TROP-2 / TACSTD2 Protein, His,Avitag™
TR2-H5223 Human Human TROP-2 / TACSTD2 Protein, His Tag

TROP-2 Customer Reviews

TROP-2 Molecule Synonym Name


TROP-2 Molecule Background

TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.

TROP-2 References

TROP-2 Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Sacituzumab govitecan IMMU-132; TROP-2-SN-38,IMMU132; TROP2SN38 Approved Immunomedics TRODELVY fda IMMUNOMEDICS INC 2020-04-22 Triple negative breast cancer Details

TROP-2 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
111In-IMP-288 111In-IMP-288; [111In]IMP-288 Phase Ⅱ Immunomedics Cancer Details
SKB-264 SKB-264 Phase Ⅱ Kelun Pharmaceutical Solid tumours Details
BAT8003 BAT-8003,BAT8003 Phase Ⅰ Bio-Thera Solutions Gastric cancer, Breast cancer Details
DAC-002 DAC-002 Phase Ⅰ Hangzhou DAC Biotech Triple negative breast cancer, Small cell lung cancer (SCLC), Non small cell lung cancer (NSCLC), Pancreatic cancer Details
DS-1062 DS-1062a; DS-1062 Phase Ⅱ Daiichi Sankyo Non small cell lung cancer (NSCLC) Details

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