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TROP-2

TROP-2 Molecule Information

Name:Tumor-associated calcium signal transducer 2
Target Synonym:Trophoblast Cell Surface Antigen 2,Tumor-associated calcium signal transducer 2,M1S1,TROP2,TACSTD2,Pancreatic carcinoma marker protein GA733-1,Tumor Associated Calcium Signal Transducer 2,GA733-1,Membrane Component, Chromosome 1, Surface Marker 1,Gastroin
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Approved

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TROP-2 Part of Bioactivity data

TR2-H5253-ELISA
Human TROP-2, Fc TagHuman TROP-2, Fc Tag (Cat. No. TR2-H5253) ELISA bioactivity

Immobilized Human TROP-2, Fc Tag (Cat. No. TR2-H5253) at 1 μg/mL (100 μL/well) can bind Mouse Monoclonal Antibody Against Human TROP-2, Mouse IgG1 with a linear range of 0.2-2 ng/mL (QC tested).

TR2-R52H3-MALS-HPLC
Rhesus macaque / Cynomolgus TROP-2, His Tag (Cat. No. ) MALS images

The purity of Rhesus macaque / Cynomolgus TROP-2, His Tag (Cat. No. TR2-R52H3) was more than 85% and the molecular weight of this protein is around 35-45 kDa verified by SEC-MALS.

Bioactivity-ELISA
Rhesus macaque / Cynomolgus TROP-2, His TagRhesus macaque / Cynomolgus TROP-2, His Tag (Cat. No. TR2-R52H3) ELISA bioactivity

Immobilized Rhesus macaque / Cynomolgus TROP-2, His Tag (Cat. No. TR2-R52H3) at 1 μg/mL (100 μL/well) can bind Mouse Monoclonal Antibody Against Human TROP-2, Mouse IgG1 with a linear range of 0.1-2 ng/mL (QC tested).

TROP-2 Customer Reviews

TROP-2 Molecule Synonym Name

TACSTD2,GA733-1,M1S1,TROP2

TROP-2 Molecule Background

TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.

TROP-2 References

TROP-2 Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Sacituzumab govitecan IMMU-132; TROP-2-SN-38 Approved Immunomedics Inc Trodelvy United States Triple Negative Breast Neoplasms s:16:"Immunomedics Inc"; 2020-04-22 Carcinoma, Ovarian Epithelial; Carcinoma, Hepatocellular; Neoplasm Metastasis; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Metastatic breast cancer; Endometrial Neoplasms; Prostatic Neoplasms; Breast Neoplasms; Urinary Bladder Neoplasms; Adenocarcinoma, Follicular; Glioblastoma; Ovarian Neoplasms; Carcinoma, Transitional Cell; Small Cell Lung Carcinoma; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Carcinoma, Renal Cell; Stomach Neoplasms; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Solid tumours; Liver Failure Details

TROP-2 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
SKB-264 SKB-264 Phase 2 Clinical Sichuan Kelun Pharmaceutical Co Ltd Stomach Neoplasms; Pancreatic Neoplasms; Carcinoma, Ovarian Epithelial; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms Details
DAC-002 DAC-002; JS-108 Phase 1 Clinical Hangzhou Dac Biotech Co Ltd Solid tumours; Triple Negative Breast Neoplasms Details
BAT8003 BAT-8003 Phase 1 Clinical Bio-Thera Solutions Ltd Solid tumours; Carcinoma, Transitional Cell Details
datopotamab DS-1062a; DS-1062; Dato-DXd Phase 3 Clinical Daiichi Sankyo Co Ltd Triple Negative Breast Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details

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