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Your Position: Home > TROP-2

TROP-2

TROP-2 Molecule Information

Name:Tumor-associated calcium signal transducer 2
Target Synonym:TROP2;GA733-1;M1S1;TACSTD2;Cell surface glycoprotein Trop-2;Membrane component chromosome 1 surface marker 1;Pancreatic carcinoma marker protein GA733-1

Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:BLA ??

TROP-2 Protein Product ListCompare or Buy

Product> Filter Results

Cat. No.	Species	Product Description
TR2-R52H3	Rhesus macaque	Rhesus macaque TROP-2 / TACSTD2 Protein, His Tag (MALS verified)
TR2-M52H6	Mouse	Mouse TROP-2 / TACSTD2 Protein, His Tag
TR2-H5253	Human	Human TROP-2 / TACSTD2 Protein, Fc Tag
TR2-H82E5	Human	Biotinylated Human TROP-2 / TACSTD2 Protein, His,Avitag™
TR2-H5223	Human	Human TROP-2 / TACSTD2 Protein, His Tag

TROP-2 Part of Bioactivity data

TR2-R52H3-MALS-HPLC

Rhesus macaque TROP-2, His Tag (Cat. No. ) MALS images

The purity of Rhesus macaque TROP-2, His Tag (Cat. No. TR2-R52H3) was more than 85% and the molecular weight of this protein is around 35-45 kDa verified by SEC-MALS.

Report

Background
TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.
References
Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.
TR2-H5223-ELISA
Immobilized Human TROP-2, His Tag (Cat. No. TR2-H5223) at 1 μg/mL (100 μL/well) can bind Monoclonal anti-TROP-2 antibody, Human IgG1 with a linear range of 0.006-0.6 μg/mL (Routinely tested).
Protocol

TROP-2 Customer Reviews

TROP-2 Molecule Synonym Name

TACSTD2,GA733-1,M1S1,TROP2

TROP-2 Molecule Background

TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.

TROP-2 References

TROP-2 Public Drug Information

Name	Research Code	Research Phase	Company	First Brand Name	First Approved Country	First Indication	First Approved Company	First Approved Date	Indications	Clinical Trials
Sacituzumab govitecan	IMMU-132; TROP-2-SN-38,IMMU132; TROP2SN38	Approved	Immunomedics	TRODELVY	fda		IMMUNOMEDICS INC	2020-04-22	Triple negative breast cancer	Details

TROP-2 Clinical Drug Information

Name	Research Code	Research Phase	Company	Indications	Clinical Trials
111In-IMP-288	111In-IMP-288; [111In]IMP-288	Phase Ⅱ	Immunomedics	Cancer	Details
SKB-264	SKB-264	Phase Ⅱ	Kelun Pharmaceutical	Solid tumours	Details
BAT8003	BAT-8003,BAT8003	Phase Ⅰ	Bio-Thera Solutions	Gastric cancer, Breast cancer	Details
DAC-002	DAC-002	Phase Ⅰ	Hangzhou DAC Biotech	Triple negative breast cancer, Small cell lung cancer (SCLC), Non small cell lung cancer (NSCLC), Pancreatic cancer	Details
DS-1062	DS-1062a; DS-1062	Phase Ⅱ	Daiichi Sankyo	Non small cell lung cancer (NSCLC)	Details