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Your Position: Home > TROP-2

TROP-2

Brief Information

Name:Tumor-associated calcium signal transducer 2
Target Synonym:Tumor-associated calcium signal transducer 2,M1S1,TROP2,TACSTD2,Pancreatic carcinoma marker protein GA733-1,Tumor Associated Calcium Signal Transducer 2,GA733-1,Membrane Component, Chromosome 1, Surface Marker 1,Gastrointestinal Tumor-Associated Antigen GA7331,Pancreatic Carcinoma Marker Protein GA7331,Cell surface glycoprotein Trop-2,Membrane component chromosome 1 surface marker 1,40kD Glycoprotein, Identified By Monoclonal Antibody GA733,Cell Surface Glycoprotein TROP2,Epithelial Glycoprotein
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Approved

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Part of Bioactivity data

TR2-R52H3-ELISA
Rhesus macaque / Cynomolgus TROP-2, His TagRhesus macaque / Cynomolgus TROP-2, His Tag (Cat. No. TR2-R52H3) ELISA bioactivity

Immobilized Rhesus macaque / Cynomolgus TROP-2, His Tag (Cat. No. TR2-R52H3) at 1 μg/mL (100 μL/well) can bind Mouse Monoclonal Antibody Against Human TROP-2, Mouse IgG1 with a linear range of 0.1-2 ng/mL (QC tested).

TR2-R52H3-MALS-HPLC
Rhesus macaque / Cynomolgus TROP-2, His Tag (Cat. No. ) MALS images

The purity of Rhesus macaque / Cynomolgus TROP-2, His Tag (Cat. No. TR2-R52H3) is more than 85% and the molecular weight of this protein is around 35-45 kDa verified by SEC-MALS.

Bioactivity-ELISA
Rhesus macaque / Cynomolgus TROP-2, His TagRhesus macaque / Cynomolgus TROP-2, His Tag (Cat. No. TR2-R52H3) ELISA bioactivity

Immobilized Rhesus macaque / Cynomolgus TROP-2, His Tag (Cat. No. TR2-R52H3) at 1 μg/mL (100 μL/well) can bind Mouse Monoclonal Antibody Against Human TROP-2, Mouse IgG1 with a linear range of 0.1-2 ng/mL (QC tested).

Customer Reviews

Synonym Name

TACSTD2,GA733-1,M1S1,TROP2

Background

TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Sacituzumab govitecan TROP-2-SN-38; GS-0132; IMMU0132; IMMU-132 Approved Immunomedics Inc Trodelvy Singapore Triple Negative Breast Neoplasms Everest Medicines Ltd 2020-04-22 Small Cell Lung Carcinoma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Carcinoma, Hepatocellular; Endometrial Neoplasms; Metastatic breast cancer; Prostatic Neoplasms; Breast Neoplasms; Urinary Bladder Neoplasms; Glioblastoma; Carcinoma, Ovarian Epithelial; Solid tumours; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Carcinoma, Renal Cell; Esophageal Neoplasms; Ovarian Neoplasms; Liver Failure Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
SKB-264 SKB-264 Phase 2 Clinical Sichuan Kelun Pharmaceutical Co Ltd Solid tumours; Stomach Neoplasms; Carcinoma, Ovarian Epithelial; Small Cell Lung Carcinoma; Carcinoma, Transitional Cell; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details
BAT-8003 BAT-8003 Phase 1 Clinical Bio-Thera Solutions Ltd Solid tumours; Carcinoma, Transitional Cell Details
FDA018 Antibody Drug Conjugate Phase 1 Clinical Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd Solid tumours Details
DAC-002 JS-108; DAC-002 Phase 1 Clinical Hangzhou Dac Biotech Company Ltd Solid tumours; Triple Negative Breast Neoplasms; Small Cell Lung Carcinoma Details
重组人源化抗Trop2单抗-SN38偶联物 ESG-401; STI-3258 Phase 2 Clinical Shanghai Escugen Biotechnology Co Ltd, Tot Biopharm Co Ltd Ovarian Neoplasms; Solid tumours; Stomach Neoplasms; Urinary Bladder Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Lung Neoplasms Details
Datopotamab deruxtecan Dato-DXd; DS-1062a; DS-1062 Phase 3 Clinical Daiichi Sankyo Co Ltd Triple Negative Breast Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details

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