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TROP-2

TROP-2 Molecule Information

Name:Tumor-associated calcium signal transducer 2
Target Synonym:TROP2?GA733-1?M1S1?TACSTD2?Cell surface glycoprotein Trop-2?Membrane component chromosome 1 surface marker 1?Pancreatic carcinoma marker protein GA733-1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:BLA ??

TROP-2 Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
TR2-H82E5 Human Biotinylated Human TROP-2 / TACSTD2 Protein, His Tag, Avi Tag (Avitag™)
TR2-H82E5-structure
TR2-H5223 Human Human TROP-2 / TACSTD2 Protein
TR2-H5223-structure
TR2-H5223-sds

TROP-2 Molecule Synonym Name

TACSTD2,GA733-1,M1S1,TROP2

TROP-2 Molecule Background

EpCAM is also known as CO171A, EGP, EGP40,GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy. Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.

TROP-2 References

TROP-2 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
111In-IMP-288 111In-IMP-288; [111In]IMP-288 Phase Ⅱ Immunomedics Cancer Details
Sacituzumab govitecan IMMU-132; TROP-2-SN-38,IMMU132; TROP2SN38 BLA Filing Immunomedics Urogenital cancer, Prostate cancer, Breast cancer, Solid tumours Details
DS-1062 DS-1062a; DS-1062 Phase Ⅰ Daiichi Sankyo Non small cell lung cancer (NSCLC) Details

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