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TROP-2

Brief Information

Name:Tumor-associated calcium signal transducer 2
Target Synonym:Tumor-associated calcium signal transducer 2,M1S1,TROP2,TACSTD2,Pancreatic carcinoma marker protein GA733-1,Tumor Associated Calcium Signal Transducer 2,GA733-1,Membrane Component, Chromosome 1, Surface Marker 1,Gastrointestinal Tumor-Associated Antigen GA7331,Pancreatic Carcinoma Marker Protein GA7331,Cell surface glycoprotein Trop-2,Membrane component chromosome 1 surface marker 1,40kD Glycoprotein, Identified By Monoclonal Antibody GA733,Cell Surface Glycoprotein TROP2,Epithelial Glycoprotein
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:11
Lastest Research Phase:Approved

Licensing

Project item Indications Research phase Cooperation demands
BDA202204 “hard-to-treat” solid tumors (pancreatic, gastric, etc) License-out or co-development License-out or co-development

Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
TR2-M82F3 Mouse Biotinylated Mouse TROP-2 / TACSTD2 Protein, Fc,Avitag™ (MALS verified)
TR2-M82F3-structure
TR2-M82F3-sds
TR2-R5255 Rhesus macaque Rhesus macaque TROP-2 / TACSTD2 Protein, Fc Tag (MALS verified)
TR2-R5255-structure
TR2-R5255-sds
TR2-H52H6 Human Human TROP-2 / TACSTD2 (88-274) Protein, His Tag
TR2-H52H6-structure
TR2-H52H6-sds
TR2-R82F6 Rhesus macaque Biotinylated Rhesus macaque TROP-2 / TACSTD2 Protein, Fc,Avitag™ (MALS verified)
TR2-R82F6-structure
TR2-R82F6-sds
TR2-R82E7 Rhesus macaque Biotinylated Rhesus macaque TROP-2 / TACSTD2 Protein, His,Avitag™ (MALS verified)
TR2-R82E7-structure
TR2-R82E7-sds
TR2-M82E9 Mouse Biotinylated Mouse TROP-2 / TACSTD2 Protein, His,Avitag™ (MALS verified)
TR2-M82E9-structure
TR2-M82E9-sds
TR2-H82F4 Human Biotinylated Human TROP-2 / TACSTD2 Protein, Fc,Avitag™
TR2-H82F4-structure
TR2-H82F4-sds
TR2-R52H9 Rabbit Rabbit TROP-2 / TACSTD2 Protein, His Tag (MALS verified)
TR2-R52H9-structure
TR2-R52H9-sds
TR2-H82Ea Human Biotinylated Human TROP-2 / TACSTD2 (88-274) Protein, His,Avitag™
TR2-H82Ea-structure
TR2-H82Ea-sds
MBS-K028 Human Human TROP-2-coupled Magnetic Beads
TR2-C52H4 Canine Canine TROP-2 / TACSTD2 Protein, His Tag
TR2-C52H4-structure
TR2-C52H4-sds
TR2-R52H3 Rhesus macaque Rhesus macaque TROP-2 / TACSTD2 Protein, His Tag (MALS verified)
TR2-R52H3-structure
TR2-R52H3-sds
TR2-M52H6 Mouse Mouse TROP-2 / TACSTD2 Protein, His Tag
TR2-M52H6-structure
TR2-M52H6-sds
TR2-H5253 Human Human TROP-2 / TACSTD2 Protein, Fc Tag
TR2-H5253-structure
TR2-H5253-sds
TR2-H82E5 Human Biotinylated Human TROP-2 / TACSTD2 Protein, His,Avitag™
TR2-H82E5-structure
TR2-H82E5-sds
TR2-H5223 Human Human TROP-2 / TACSTD2 Protein, His Tag (MALS verified)
TR2-H5223-structure
TR2-H5223-sds
ACRO Quality

Part of Bioactivity data

TR2-H52H6-ELISA
 TROP-2 ELISA

Immobilized Human TROP-2 (88-274) Protein, His Tag (Cat. No. TR2-H52H6) at 1 μg/mL (100 μL/well) can bind Mouse Monoclonal Antibody Against Human TROP-2 Protein,Mouse IgG1 with a linear range of 0.2-4 ng/mL (QC tested).

TR2-M82F3-MALS-HPLC
TROP-2 MALS images

The purity of Biotinylated Mouse TROP-2 Protein, Fc,Avitag (Cat. No. TR2-M82F3) is more than 90% and the molecular weight of this protein is around 120-145 kDa verified by SEC-MALS.

Customer Reviews

Synonym Name

TACSTD2,GA733-1,M1S1,TROP2

Background

TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Sacituzumab govitecan GS-0132; IMMU-132; TROP-2-SN-38; IMMU0132 Approved Immunomedics Inc 拓达维, Trodelvy United States Triple Negative Breast Neoplasms Immunomedics Inc 2020-04-22 Carcinoma, Ovarian Epithelial; Carcinoma, Hepatocellular; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Brain metastases; Metastatic breast cancer; Prostatic Neoplasms; Breast Neoplasms; Urinary Bladder Neoplasms; Neoplasms; Triple Negative Breast Neoplasms; Solid tumours; Pancreatic Neoplasms; Glioblastoma; Small Cell Lung Carcinoma; Carcinoma, Transitional Cell; Stomach Neoplasms; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Liver Failure; Ovarian Neoplasms Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
BL-M02D1 Phase 1 Clinical Baili-Bio (Chengdu) Pharmaceutical Co Ltd, Sichuan Baili Pharmaceutical Co Ltd Solid tumours; Triple Negative Breast Neoplasms; Digestive System Neoplasms; Breast Neoplasms; Gastrointestinal Neoplasms Details
BIO-106 BIO-106 Phase 2 Clinical Hangzhou Baikai Biopharmaceutical Co Ltd Solid tumours; Neoplasms Details
KJ-103 KJ-103 Phase 1 Clinical Kisoji Biotechnology Inc Rejection of renal transplantation; Solid tumours Details
DAC-002 JS-108; DAC-002 Phase 1 Clinical Solid tumours; Triple Negative Breast Neoplasms; Small Cell Lung Carcinoma; Neoplasms Details
BAT-8008 BAT8008; BAT-8008 Phase 1 Clinical Bio-Thera Solutions Ltd Solid tumours; Neoplasms Details
SHR-A1921 SHR-A1921; SHRA1921 Phase 1 Clinical Suzhou Suncadia Biopharmaceuticals Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd Solid tumours; Breast Neoplasms Details
MHB036C MHB-036C Phase 2 Clinical Minghui Pharmaceutical Pty Ltd Solid tumours Details
重组人源化抗Trop2单抗-SN38偶联物 ESG-401; STI-3258 Phase 2 Clinical Shanghai Escugen Biotechnology Co Ltd, Tot Biopharm Co Ltd Solid tumours; Ovarian Neoplasms; Stomach Neoplasms; Neoplasms; Urinary Bladder Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Lung Neoplasms Details
FDA018 Antibody Drug Conjugate FDA-018-ADC; FDA018-ADC Phase 2 Clinical Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd Solid tumours; Triple Negative Breast Neoplasms; Neoplasms; Breast Neoplasms; Neoplasm Metastasis Details
SKB-264 MK-2870; SKB-264 Phase 3 Clinical Sichuan Kelun Pharmaceutical Co Ltd Solid tumours; Stomach Neoplasms; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Small Cell Lung Carcinoma; Carcinoma, Ovarian Epithelial; Breast Neoplasms; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
Datopotamab deruxtecan Dato-DXd; DS-1062a; DS-1062 Phase 3 Clinical Daiichi Sankyo Co Ltd Solid tumours; Ovarian Neoplasms; Stomach Neoplasms; Triple Negative Breast Neoplasms; Prostatic Neoplasms, Castration-Resistant; Breast Neoplasms; Prostatic Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details

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