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TROP-2

Brief Information

Name:Tumor-associated calcium signal transducer 2
Target Synonym:Tumor-associated calcium signal transducer 2,M1S1,TROP2,TACSTD2,Pancreatic carcinoma marker protein GA733-1,Tumor Associated Calcium Signal Transducer 2,GA733-1,Membrane Component, Chromosome 1, Surface Marker 1,Gastrointestinal Tumor-Associated Antigen GA7331,Pancreatic Carcinoma Marker Protein GA7331,Cell surface glycoprotein Trop-2,Membrane component chromosome 1 surface marker 1,40kD Glycoprotein, Identified By Monoclonal Antibody GA733,Cell Surface Glycoprotein TROP2,Epithelial Glycoprotein
Number of Launched Drugs:3
Number of Drugs in Clinical Trials:25
Lastest Research Phase:Approved

Antibody Licensing

Project Name Project Stage Molecule Type Host Species Therapeutic Area Indications
Trop2 ADC -01 IND Solid Tumor Non-small cell lung cancer,Pancreatic cancer

Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
TR2-C52H5 Cynomolgus Cynomolgus TROP-2 / TACSTD2 Protein, His Tag (MALS verified)
TR2-C52H5-structure
TR2-C52H5-sds
TR2-C82E3 Cynomolgus Biotinylated Cynomolgus TROP-2 / TACSTD2 Protein, His,Avitag™ (MALS verified)
TR2-C82E3-structure
TR2-C82E3-sds
TR2-M82F3 Mouse Biotinylated Mouse TROP-2 / TACSTD2 Protein, Fc,Avitag™ (MALS verified)
TR2-M82F3-structure
TR2-M82F3-sds
TR2-R5255 Rhesus macaque Rhesus macaque TROP-2 / TACSTD2 Protein, Fc Tag (MALS verified)
TR2-R5255-structure
TR2-R5255-sds
TR2-H52H6 Human Human TROP-2 / TACSTD2 (88-274) Protein, His Tag
TR2-H52H6-structure
TR2-H52H6-sds
TR2-R82F6 Rhesus macaque Biotinylated Rhesus macaque TROP-2 / TACSTD2 Protein, Fc,Avitag™ (MALS verified)
TR2-R82F6-structure
TR2-R82F6-sds
CEA-B032 Human ClinMax™ Human Soluble TROP-2 ELISA Kit, PRO
TR2-R82E7 Rhesus macaque Biotinylated Rhesus macaque TROP-2 / TACSTD2 Protein, His,Avitag™ (MALS verified)
TR2-R82E7-structure
TR2-R82E7-sds
TR2-M82E9 Mouse Biotinylated Mouse TROP-2 / TACSTD2 Protein, His,Avitag™ (MALS verified)
TR2-M82E9-structure
TR2-M82E9-sds
TR2-H82F4 Human Biotinylated Human TROP-2 / TACSTD2 Protein, Fc,Avitag™
TR2-H82F4-structure
TR2-H82F4-sds
TR2-R52H9 Rabbit Rabbit TROP-2 / TACSTD2 Protein, His Tag (MALS verified)
TR2-R52H9-structure
TR2-R52H9-sds
TR2-H82Ea Human Biotinylated Human TROP-2 / TACSTD2 (88-274) Protein, His,Avitag™ (MALS verified)
TR2-H82Ea-structure
TR2-H82Ea-sds
MBS-K028 Human Human TROP-2-coupled Magnetic Beads
TR2-C52H4 Canine Canine TROP-2 / TACSTD2 Protein, His Tag
TR2-C52H4-structure
TR2-C52H4-sds
TR2-R52H3 Rhesus macaque Rhesus macaque TROP-2 / TACSTD2 Protein, His Tag (MALS verified)
TR2-R52H3-structure
TR2-R52H3-sds
TR2-M52H6 Mouse Mouse TROP-2 / TACSTD2 Protein, His Tag (MALS verified)
TR2-M52H6-structure
TR2-M52H6-sds
TR2-H5253 Human Human TROP-2 / TACSTD2 Protein, Fc Tag (MALS verified)
TR2-H5253-structure
TR2-H5253-sds
TR2-H82E5 Human Biotinylated Human TROP-2 / TACSTD2 Protein, His,Avitag™ (MALS verified)
TR2-H82E5-structure
TR2-H82E5-sds
TR2-H5223 Human Human TROP-2 / TACSTD2 Protein, His Tag (MALS verified)
TR2-H5223-structure
TR2-H5223-sds
ACRO Quality

Part of Bioactivity data

TR2-R52H3-SPR
 TROP-2 SPR

Captured Trop2 antibody on CM5 chip via anti-mouse antibodies surface can bind Rhesus macaque TROP-2 Protein, His Tag (Cat. No. TR2-R52H3) with an affinity constant of 5.48 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

TR2-H5253-SPR
 TROP-2 SPR

Captured Trop2 antibody on CM5 chip via anti-mouse antibodies surface can bind Human TROP-2, Fc Tag (Cat. No. TR2-H5253) with an affinity constant of 3.45 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Customer Reviews

Synonym Name

TACSTD2,GA733-1,M1S1,TROP2

Background

TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Sacituzumab govitecan IMMU-132; TROP-2-SN-38; IMMU0132; GS-0132; IMMU-0132 Approved Immunomedics Inc, Gilead Sciences Inc Trodelvy, 拓达维, TRODELVY United States Triple Negative Breast Neoplasms Immunomedics Inc 2020-04-22 Brain metastases; Mesothelioma; Urinary Bladder Neoplasms; Klatskin Tumor; Breast Neoplasms; Cholangiocarcinoma; Prostatic Neoplasms; Bile Duct Neoplasms; Metastatic breast cancer; Hormone-Resistant Prostate Neoplasms; Thymoma; Esophageal Squamous Cell Carcinoma; Endometrial Neoplasms; Thyroid Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Solid tumours; Thyroid Carcinoma, Anaplastic; Salivary Gland Neoplasms; Carcinoma, Ovarian Epithelial; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms; Glioblastoma; Carcinoma, Transitional Cell; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Esophageal Neoplasms; Biliary Tract Neoplasms; Ovarian Neoplasms; Liver Failure Details
Datopotamab deruxtecan DS-1062a; DS-1062; Dato-DXd; S-1062a Approved Daiichi Sankyo Co Ltd Datroway, DATROWAY Japan Breast Neoplasms Daiichi Sankyo Co Ltd 2024-12-27 Solid tumours; Biliary Tract Neoplasms; Ovarian Neoplasms; Carcinoma; Stomach Neoplasms; Triple Negative Breast Neoplasms; Prostatic Neoplasms, Castration-Resistant; Breast Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Endometrial Neoplasms; Metastatic breast cancer; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details
Sacituzumab tirumotecan SKB-264; MK-2870; SKB264; sac-TMT Approved Klus Pharma Inc 佳泰莱 Mainland China Triple Negative Breast Neoplasms Sichuan Kelun-Biotech Biopharmaceutical Co Ltd 2024-11-22 Triple Negative Breast Neoplasms; Gastrointestinal Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Metastatic breast cancer; Carcinoma, Pancreatic Ductal; Endometrial Neoplasms; Colorectal Neoplasms; Breast Neoplasms; Urinary Bladder Neoplasms; Biliary Tract Neoplasms; Carcinoma, Transitional Cell; Small Cell Lung Carcinoma; Carcinoma, Ovarian Epithelial; Carcinoma; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Solid tumours Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
SHR-A1921 SHR-A1921; SHRA1921; SHR-1921 Phase 3 Clinical Suzhou Suncadia Biopharmaceuticals Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd Solid tumours; Ovarian Neoplasms; Carcinoma, Ovarian Epithelial; Triple Negative Breast Neoplasms; Salivary Gland Neoplasms; Neoplasms; Breast Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Metastatic breast cancer; Brain metastases; Carcinoma, Non-Small-Cell Lung Details
ESG-401 STI-3258; OQY-3258; ESG-401 Phase 3 Clinical Shanghai Escugen Biotechnology Co Ltd Ovarian Neoplasms; Solid tumours; Stomach Neoplasms; Triple Negative Breast Neoplasms; Neoplasms; Urinary Bladder Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Metastatic breast cancer Details
FDA018 Antibody Drug Conjugate FDA018-ADC; FDA-018-ADC Phase 3 Clinical Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd Solid tumours; Neoplasms; Triple Negative Breast Neoplasms; Breast Neoplasms Details
GQ-1010 GQ-1010; BHV1510; BHV-1510; GQ1010; PBI-410 Phase 2 Clinical GeneQuantum Healthcare (Suzhou) Co Ltd Solid tumours; Carcinoma; Triple Negative Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Trop2 CAR-NK cell therapy(Henan Provincial Cancer Hospital) Phase 2 Clinical Henan Provincial Cancer Hospital Carcinoma, Non-Small-Cell Lung Details
OBI-992 BSI-992; BSI992; R-992; OBI-992 Phase 2 Clinical Boaoxin Biotechnology(Nanjing) Co Ltd Solid tumours; Stomach Neoplasms; Small Cell Lung Carcinoma; Carcinoma, Non-Small-Cell Lung Details
JSKN-016 JSKN016; JSKN-016 Phase 2 Clinical Jiangsu Alphamab Biopharmaceuticals Co Ltd Solid tumours; Neoplasms; Carcinoma, Non-Small-Cell Lung Details
HS-20105 HS-20105; HS20105 Phase 2 Clinical Hansoh BioMedical R&D Company Solid tumours Details
IBI130 IBI130; IBI-130 Phase 2 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours; Neoplasm Metastasis Details
Anti TROP2 antibody drug conjugate ADC(Fudan University) Phase 2 Clinical Fudan University Triple Negative Breast Neoplasms Details
9MW-2921 9MW2921; 9MW-2921 Phase 2 Clinical Mabwell (Shanghai) Bioscience Co Ltd Solid tumours Details
MHB036C MHB-036C Phase 2 Clinical Minghui Pharmaceutical Pty Ltd Solid tumours; Lung Neoplasms Details
BAT-8008 BAT-8008; BAT8008 Phase 2 Clinical Bio-Thera Solutions Ltd Solid tumours; Triple Negative Breast Neoplasms Details
DB-1305 DB1305; BNT325; BNT-325; DB-1305 Phase 2 Clinical Duality Biologics (Suzhou) Co Ltd Solid tumours Details
BIO-106 BIO-106 Phase 2 Clinical Hangzhou Baikai Biopharmaceutical Co Ltd Solid tumours; Neoplasms Details
BL-M02D1 Phase 2 Clinical Baili-Bio (Chengdu) Pharmaceutical Co Ltd, Sichuan Baili Pharmaceutical Co Ltd Solid tumours; Triple Negative Breast Neoplasms; Digestive System Neoplasms; Breast Neoplasms; Gastrointestinal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
LCB-84 LCB-84 Phase 2 Clinical Legochem Biosciences Inc Solid tumours Details
JS-108 DAC-002; JS-108; DAC-002/JS108 Phase 1 Clinical Hangzhou Dac Biotech Company Ltd Solid tumours; Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms Details
IBR-822 IBR822; IBR-822 Phase 1 Clinical Imbioray (Hangzhou) Biomedicine Co Ltd Solid tumours Details
DXC-1002 DXC1002; DXC-1002 Phase 1 Clinical Hangzhou Dac Biotech Company Ltd Solid tumours Details
DS-001 DS001; DS-001 Phase 1 Clinical Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences, Dartsbio Pharmaceuticals Ltd Neoplasms Details
FZ-AD004 FZ-AD004 Phase 1 Clinical Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd Solid tumours Details
BCG-011 DM-001; BCG-011 Phase 1 Clinical Biocytogen Pharmaceuticals (Beijing) Co Ltd Solid tumours; Triple Negative Breast Neoplasms; Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details
MT-302 MT-302 Phase 1 Clinical Myeloid Therapeutics Inc Carcinoma; Colonic Neoplasms; Breast Neoplasms; Lung Neoplasms Details

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