Leave message Can’t find what you’re looking for? Fill out this form to inquire about our custom protein services! Inquire about our Custom Services >>
Explore our series of high-quality proteins covering comprehensive diagnostic indicators in order to facilitate the in vitro diagnostic research of neurological diseases.
Pre-formed fibrils are an invaluable preclinical model for exploring pathogenesis of neurological diseases through aggregation of misfolded proteins. Explore our pre-seeded PFFs to use in your research.
Neural factors are a class of protein molecules with neurotrophic activity that can promote the survival and regeneration of nerve cells. Explore our series of recombinant neural factors to support the culture and differentiation of nerve cells.
Partnering with Diagnostic Biochips, we now provide solutions for in vivo electrophysiology recordings, including high-quality multi-channel electrodes and other products to facilitate high-quality, efficient analysis of neural circuit structure and function.
Protein markers are an essential component in biological research and drug development. Whether it is for protein electrophoresis or western blot, our pre-stained protein markers help you quickly determine the molecular weight of the target protein or evaluate the transfer efficiency.
Streptavidin is a tetrameric protein providing 4 high-affinity biotin binding sites. We offer a wide array of products pre-conjugated with streptavidin to support your research as well as biotinylated proteins.
Setting the corresponding isotype control antibody to detect non-specific binding can reduce the generation of false positive results and evaluate the possible influencing factors accurately in the drug development process. Explore our isotype controls for your research.
The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. Explore our comprehensive collection of recombinant Fc receptor proteins!
We committed to accelerating the research, development, approval, and commercialization of infectious disease vaccines. With this idea, ViruStop is specially designed for virus research!
Auf der Grundlage der Erkenntnis zur Wirkung von Antigenen in der adaptiven Immunantwort wird die T-Zellen-Aktivität größtenteils während der Aktivierung erreicht, wobei zwei Signale erforderlich sind. Zunächst müssen T-Zellen-Rezeptoren spezifisch Peptide angreifen, die von Haupthistokompatibilitätskomplexen (MHCs) auf Antigen-präsentierenden Zellen (APCs) präsentiert werden; danach müssen co-stimulatorische/co-inhibitorische Rezeptoren auf T-Zellen die B7-Ligandenfamilie binden, die auf APCs exprimiert wird, um die Situation von T-Zellen zu regulieren.
Dies stellt einen Schlüsselkontrollpunkt bei der Regulierung der T-Zellen-Immunität bereit. Die T-Zellen-Aktivierung wird durch das angeborene Immunsystem durch positive und negative co-stimulatorische Moleküle reguliert. Es zeigt sich, dass Mitglieder der B7-Familie wichtig für die Regulierung von T-Zellen-Antworten sind. Die B7-Ligandenfamilie spielt also eine bedeutende Rolle bei Krebserkrankungen und Autoimmunerkrankungen beim Menschen. Die B7-Ligandenfamilie umfasst 11 Mitglieder, nämlich B7-1, B7-2, B7-H1, B7-DC, B7-H2, B7-H3, B7-H4, B7-H5, BTNL2, B7-H6 und B7- H7.
ACROBiosystems hat einzigartige Proteine der B7-Familie mit hoher Reinheit und hoher Bioaktivität entwickelt, die für Immun-, Antikörper-Screening, SPR, Zellaktivitätsnachweis und andere Experimente geeignet sind und die Entwicklung von Antikörper-Medikamenten beschleunigen können.
The purity of Human B7-H3, His Tag (Cat. No. B73-H52E2) is more than 90% and the molecular weight of this protein is around 30-40 kDa verified by SEC-MALS.
Hohe Konsistenz von Charge zu Charge
Entwickelt für verschiedene Anwendungen in der Arzneimittelentwicklung
Application 1: Development and screening of antibody drugs
Immobilized Human ICOS, Fc Tag (Cat. No. ICS-H5258) at 1 μg/mL (100 μL/well) can bind Human B7-H2, His Tag (Cat. No. B72-H5221) with a linear range of 5-78 ng/mL (QC tested).
Serial dilutions of Ipilimumab were added into Human CTLA-4, Fc Tag (Cat. No. CT4-H5255): Biotinylated Human B7-1, Fc,Avitag (Cat. No. B71-H82F2) binding reactions. The half maximal inhibitory concentration (IC50) is 0.8260 μg/mL (Routinely tested).
Application 2: Affinity detection of antibody drugs
Anti-Human PD-L1 Mab (Human IgG1) captured on CM5 chip via anti-human IgG Fc antibodies surface, can bind Human PD-L1, His Tag (Cat. No. PD1-H5229) with an affinity constant of 0.286 nM as determined in a SPR assay (Biacore T200)(Routinely tested).
Application 3: Cell-based assay
Flow Cytometry assay shows that Biotinylated Human B7-1, Fc,Avitag (Cat. No. B71-H82F2) can bind to 293 cell overexpressing human CTLA-4. The concentration of Human B7-1 is 0.3 μg/mL (Routinely tested).
FACS analysis shows that the binding of Biotinylated Human B7-1, Fc,Avitag (Cat. No. B71-H82F2) to 293 overexpressing CTLA-4 was inhibited by increasing concentration of neutralizing Anti-Human CTLA-4 antibody. The concentration of B7-1 used is 0.3 μg/mL. The IC50 is 3.025 μg/mL (Routinely tested).
Human B7-H3 (4Ig), His Tag (Cat. No. B7B-H52E7) inhibits Anti-CD3-induced proliferation of PBMC. The EC50 for this effect is 7.95 μg/mL (Routinely tested).
Immobilized cell surface PD-1 (5x104 of cells per well) can bind Human PD-L1, Fc Tag (Cat. No. PD1-H5258) with an EC50 of 0.029 μg/mL (Routinely tested).
Kundenrezensionen
This web search service is supported by Google Inc.
A-Z
Stimulatory signal 
Inhibitory signal
