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Your Position: Home > Spike protein

Spike protein

Brief Information

Name:Interleukin-17 receptor A
Target Synonym:CDw217,IL-17 receptor A,IL17R,IL17RA,Interleukin 17 Receptor A,IL-17RA,Interleukin 17 Receptor,CD217 Antigen,HIL-17R,CANDF5,CD217,IMD51,Interleukin-17 receptor A
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
SPN-C82Eu SARS-CoV-2 Biotinylated SARS-CoV-2 Spike Trimer, His,Avitag™ (BA.5/Omicron)
PSSO-HLC015 SARS-CoV-2 SARS-CoV-2 Spike (Omicron BA.2.12.1) Fluc Pseudovirus
PSSO-HLC017 SARS-CoV-2 SARS-CoV-2 Spike (Omicron BA.3) Fluc Pseudovirus
PSSO-HLC016 SARS-CoV-2 SARS-CoV-2 Spike (Omicron BA.4 & BA.5) Fluc Pseudovirus
RAS-T094 SARS-CoV-2 Anti-SARS-CoV-2 Antibody IgG Quantitative and Titer Detection Kit (Spike Trimer)
SPN-C82Es SARS-CoV-2 Biotinylated SARS-CoV-2 Spike Trimer, His,Avitag™ (BA.2.12.1/Omicron) (MALS verified)
SPN-C82Et SARS-CoV-2 Biotinylated SARS-CoV-2 Spike Trimer, His,Avitag™ (BA.4/Omicron) (MALS verified)
SPN-C82Et-sds
PSSO-HLC014 SARS-CoV-2 SARS-CoV-2 Spike (Omicron BA.2) Fluc Pseudovirus
PSSO-HLC012 SARS-CoV-2 SARS-CoV-2 Spike (Omicron BA.1) Fluc Pseudovirus
SPN-C522e SARS-CoV-2 SARS-CoV-2 Spike Trimer, His Tag (BA.5/Omicron) (MALS verified)
SPN-C522e-sds
SPN-C522a SARS-CoV-2 SARS-CoV-2 Spike Trimer, His Tag (BA.1/Omicron) (MALS verified)
SPN-C522a-sds
SPN-C522d SARS-CoV-2 SARS-CoV-2 Spike Trimer, His Tag (BA.2.12.1/Omicron) (MALS verified)
SPN-C522d-sds
SPN-C522b SARS-CoV-2 SARS-CoV-2 Spike Trimer, His Tag (BA.2/Omicron) (MALS verified)
SPN-C522b-sds
SPN-C522c SARS-CoV-2 SARS-CoV-2 Spike Trimer, His Tag (BA.3/Omicron) (MALS verified)
SPN-C522c-sds
SPN-B5283 Bat coronavirus Bat coronavirus Spike Trimer (K978P, V979P), His Tag&Twin-Strep Tag (MALS verified)
SPN-B5283-structure
SPN-B5283-sds
SPN-C5227 SARS-CoV-2 SARS-CoV-2 Spike Trimer, His Tag (BA.2+L452M/Omicron) (MALS verified)
SPN-C5227-sds
SPN-C5228 SARS-CoV-2 SARS-CoV-2 Spike Trimer, His Tag (BA.2+L452R, F486V/Omicron) (MALS verified)
SPN-C5228-sds
SPN-C5229 SARS-CoV-2 SARS-CoV-2 Spike Trimer, His Tag (BA.4/Omicron) (MALS verified)
SPN-C5229-sds
SPN-C82Er SARS-CoV-2 Biotinylated SARS-CoV-2 Spike Trimer, His,Avitag™ (BA.2/Omicron) (MALS verified)
SPN-C82Er-sds
PSSD-HLGB004 SARS-CoV-2 SARS-CoV-2 Spike (Delta plus K417N) Fluc-GFP Pseudovirus
PSSL-HLGB006 SARS-CoV-2 SARS-CoV-2 Spike (Lambda) Fluc-GFP Pseudovirus
PSSG-HLGB009 SARS-CoV-2 SARS-CoV-2 Spike (Gamma) Fluc-GFP Pseudovirus
PSSB-HLGB005 SARS-CoV-2 SARS-CoV-2 Spike (Beta) Fluc-GFP Pseudovirus
PSSW-HLGB010 SARS-CoV-2 SARS-CoV-2 Spike (D614G) Fluc-GFP Pseudovirus
PSSM-HLGB007 SARS-CoV-2 SARS-CoV-2 Spike (Mu) Fluc-GFP Pseudovirus
PSSO-HLGB011 SARS-CoV-2 SARS-CoV-2 Spike (Omicron BA.2) Fluc-GFP Pseudovirus
PSSA-HLGB008 SARS-CoV-2 SARS-CoV-2 Spike (Alpha) Fluc-GFP Pseudovirus
SPN-C5226 SARS-CoV-2 SARS-CoV-2 Spike Trimer, His Tag (XD/BA.1 x AY.4 recombinant) (MALS verified)
SPN-C5226-sds
RAS-T089 SARS-CoV-2 Mouse Anti-SARS-CoV-2 (BA.2) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)
RAS-T089-sds
RAS-A081 SARS-CoV-2 SARS-CoV-2 Spike Trimer (B.1.1.529) Specific ELISA Kit (For Vaccine Development)
RAS-A055 SARS-CoV-2 SARS-CoV-2 Spike Trimer (B.1.617.2) Specific ELISA Kit (For Vaccine Development)
SPN-C5225 SARS-CoV-2 SARS-CoV-2 Spike Trimer, His Tag (BA.3/Omicron) (MALS verified)
SPN-C5225-sds
SPN-S82E3 SARS Biotinylated SARS Spike protein (R667A, K968P, V969P), His,Avitag™ (MALS verified)
SPN-S82E3-structure
SPN-S82E3-sds
SPN-C5224 SARS-CoV-2 SARS-CoV-2 Spike Trimer, His Tag (BA.1.1/Omicron) (MALS verified)
SPN-C5224-sds
SPN-C5223 SARS-CoV-2 SARS-CoV-2 Spike Trimer, His Tag (BA.2/Omicron) (MALS verified)
SPN-C5223-sds
SCT-G448 Mouse Anti-SARS-CoV-2 Spike & J chain & Secretory Component Antibody, Mouse IgA
SCT-M399a Mouse Anti-SARS-CoV-2 Spike & J chain Antibody, Mouse IgA
RAS-T070 SARS-CoV-2 Mouse Anti-SARS-CoV-2 (B.1.617.2) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)
PSSO-HLGB003 SARS-CoV-2 SARS-CoV-2 Spike (Omicron) Fluc-GFP Pseudovirus
PSSD-HLGB002 SARS-CoV-2 SARS-CoV-2 Spike (Delta) Fluc-GFP Pseudovirus
PSSW-HLGB001 SARS-CoV-2 SARS-CoV-2 Spike (WT) Fluc-GFP Pseudovirus
RAS-T053 SARS-CoV-2 Anti-SARS-CoV-2 Antibody IgM Titer Serologic Assay Kit (Spike Trimer)
RAS-T058 SARS-CoV-2 Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike Trimer))
RAS-T060 SARS-CoV-2 Mouse Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)
RAS-T063 SARS-CoV-2 Monkey Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)
SPN-C52Hz SARS-CoV-2 SARS-CoV-2 Spike Trimer, His Tag (B.1.1.529/Omicron) (MALS verified)
SPN-C52Hz-sds
SPN-C82Ee SARS-CoV-2 Biotinylated SARS-CoV-2 Spike Trimer, His,Avitag™ (BA.1/Omicron) (MALS verified)
SPN-C82Ee-sds
RAS-T048 Human Anti-SARS-CoV-2 Antibody IgG Quantitative Detection Kit (Spike Trimer)
RAS-T046 Monkey Monkey Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike Trimer)
SPN-C52Hu SARS-CoV-2 SARS-CoV-2 Spike Trimer (T19R, T95I, Y145H, EF156-157del, R158G, A222V, L452R, T478K, D614G, P681R, D950N), His Tag (MALS verified)
SPN-C52Hu-sds
SPN-H52Hz HCoV-OC43 HCoV-OC43 Spike protein, His Tag
SPN-H52Hz-structure
SPN-H52Hz-sds
CMO-PAN001 SARS-CoV-2 SARS-CoV-2 (WT) Pseudovirus Neutralization Reagents
CMO-PAN003 SARS-CoV-2 SARS-CoV-2 (Omicron) Pseudovirus Neutralization Reagents
SPN-C52Hb SARS-CoV-2 SARS-CoV-2 Spike Trimer (C136F, Y144del, R190S, D215G, LA242-243del, Y449H, E484K, N501Y, D614G, H655Y, N679K, T716I, T859N), His Tag (MALS verified)
SPN-C52Hb-sds
SPN-C82Ek SARS-CoV-2 Biotinylated SARS-CoV-2 Spike Trimer (T95I, Y144S, Y145N, R346K, E484K, N501Y, D614G, P681H, D950N), His,Avitag™ (MALS verified)
SPN-C82Ek-sds
SPN-C52Ha SARS-CoV-2 SARS-CoV-2 Spike Trimer (T95I, Y144S, Y145N, R346K, E484K, N501Y, D614G, P681H, D950N), His Tag (MALS verified)
SPN-C52Ha-sds
SPN-C82Eq SARS-CoV-2 Biotinylated SARS-CoV-2 Spike Trimer (C136F, Y144del, R190S, D215G, LA242-243del, Y449H, E484K, N501Y, D614G, H655Y, N679K, T716I, T859N), His,Avitag™ (MALS verified)
SPN-C82Eq-sds
CHEK-STP024 SARS-CoV-2 HEK293/SARS-CoV-2 Spike Stable Cell Line
RAS-A039 SARS-CoV-2 SARS-CoV-2 Spike Protein ELISA Kit (For Vaccine Development)
SPN-C82Ei SARS-CoV-2 Biotinylated SARS-CoV-2 Spike Trimer (T19R, V70F, FR157-158Del, A222V, W258L, K417N, L452R, T478K, D614G, P681R, D950N), His,Avitag™ (MALS verified)
SPN-C82Ei-sds
SPN-C52Ht SARS-CoV-2 SARS-CoV-2 Spike Trimer (T19R, V70F, FR157-158Del, A222V, W258L, K417N, L452R, T478K, D614G, P681R, D950N), His Tag (MALS verified)
SPN-C52Ht-sds
RAS-T025 SARS-CoV-2 Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike Trimer)
SPN-C52Hs SARS-CoV-2 SARS-CoV-2 Spike Trimer (G75V, T76I, SYLTPGD 247-253 del, L452Q, F490S, D614G, T859N), His Tag (MALS verified)
SPN-C52Hs-sds
SPN-C82Eh SARS-CoV-2 Biotinylated SARS-CoV-2 Spike Trimer (G75V, T76I, SYLTPGD 247-253 del, L452Q, F490S, D614G, T859N), His,Avitag™ (MALS verified)
SPN-C82Eh-sds
MBS-K038 SARS-CoV-2 SARS-CoV-2 (Delta) Spike Trimer-coupled Magnetic Beads
SPN-C52Hm SARS-CoV-2 SARS-CoV-2 Spike Trimer (K417N, D614G), His Tag (MALS verified)
SPN-C52Hm-sds
SPN-C52Hq SARS-CoV-2 SARS-CoV-2 Spike Trimer (E484K, D614G), His Tag (MALS verified)
SPN-C52Hq-sds
SPN-C52Hp SARS-CoV-2 SARS-CoV-2 Spike Trimer (N501Y, D614G), His Tag (MALS verified)
SPN-C52Hp-sds
SPN-C52Hn SARS-CoV-2 SARS-CoV-2 Spike Trimer (K417T, D614G), His Tag (MALS verified)
SPN-C52Hn-sds
RAS-N041 SARS-CoV-2 Anti-SARS-CoV-2 (B.1.617.2) Neutralizing Antibody Titer Serologic Assay Kit (Spike Trimer)
SPN-C52Hh SARS-CoV-2 SARS-CoV-2 Spike Trimer (P26S, HV69-70del, V126A, Y144del, LLA241-243del, H245Y, S477N, E484K, D614G, P681H, T1027I, D1118H), His Tag (MALS verified)
SPN-C52Hh-sds
SPN-C82Ed SARS-CoV-2 Biotinylated SARS-CoV-2 Spike Trimer (P26S, HV69-70del, V126A, Y144del, LLA241-243del, H245Y, S477N, E484K, D614G, P681H, T1027I, D1118H), His,Avitag™ (MALS verified)
SPN-C82Ed-sds
SPN-C52He SARS-CoV-2 SARS-CoV-2 Spike Trimer (T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N), His Tag (MALS verified)
SPN-C52He-sds
SPN-C82Ec SARS-CoV-2 Biotinylated SARS-CoV-2 Spike Trimer (T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N), His,Avitag™ (MALS verified)
SPN-C82Ec-sds
RAS-T023 SARS-CoV-2 Mouse Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike Trimer)
SPN-C52Hr SARS-CoV-2 SARS-CoV-2 Spike Trimer (T95I, G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H), His Tag (MALS verified)
SPN-C52Hr-sds
SPN-C82E7 SARS-CoV-2 Biotinylated SARS-CoV-2 Spike Trimer (T95I, G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H), His,Avitag™ (MALS verified)
SPN-C82E7-sds
SPN-H82E3 HCoV-HKU1 Biotinylated HCoV-HKU1 (isolate N5) Spike Trimer, His,Avitag™ (MALS verified)
SPN-H82E3-structure
SPN-H82E3-sds
TAS-K025 SARS-CoV-2 Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike Trimer)
SPN-H82E6 HCoV-NL63 Biotinylated HCoV-NL63 Spike protein, His,Avitag™
SPN-H82E6-structure
SPN-H82E6-sds
SPN-H52H5 HCoV-HKU1 HCoV-HKU1 (isolate N5) Spike Trimer, His Tag (MALS verified)
SPN-H52H5-structure
SPN-H52H5-sds
SPN-H52H4 HCoV-NL63 HCoV-NL63 S protein, His Tag
SPN-H52H4-structure
SPN-H52H4-sds
SPN-H52H3 HCoV-229E HCoV-229E Spike protein, His Tag
SPN-H52H3-structure
SPN-H52H3-sds
MBS-K029 SARS-CoV-2 SARS-CoV-2 Spike Trimer (B.1.1.7) Coupled Magnetic Beads
MBS-K031 SARS-CoV-2 SARS-CoV-2 Spike Trimer (P.1) Coupled Magnetic Beads
MBS-K030 SARS-CoV-2 SARS-CoV-2 Spike Trimer (B.1.351) Coupled Magnetic Beads
RAS-T027 SARS-CoV-2 Anti-SARS-CoV-2 (B.1.1.7) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)
RAS-A020 SARS-CoV-2 SARS-CoV-2 Spike Protein Titer Assay Kit
RAS-T033 SARS-CoV-2 Anti-SARS-CoV-2 (P.1) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)
RAS-T030 SARS-CoV-2 Anti-SARS-CoV-2 (B.1.351) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)
SPN-M52H4 MERS MERS Spike protein trimer (R748A, R751A, V1060P, L1061P), His Tag (MALS verified)
SPN-M52H4-structure
SPN-M52H4-sds
SPN-C52Hk SARS-CoV-2 SARS-CoV-2 S protein (L18F, D80A, D215G, 242-244del, R246I, K417N, E484K, N501Y, D614G, A701V) trimer, His Tag (MALS verified)
SPN-C52Hk-sds
SPN-C82E5 SARS-CoV-2 Biotinylated SARS-CoV-2 S protein (HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H) trimer, His,Avitag™ (MALS verified)
SPN-C82E5-sds
SPN-C82E4 SARS-CoV-2 Biotinylated SARS-CoV-2 S protein (L18F, D80A, D215G, 242-244del, R246I, K417N, E484K, N501Y, D614G, A701V) trimer, His,Avitag™ (MALS verified)
SPN-C82E4-sds
SPN-C82E6 SARS-CoV-2 Biotinylated SARS-CoV-2 S protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F) trimer, His,Avitag™ (MALS verified)
SPN-C82E6-sds
SPN-C52Hg SARS-CoV-2 SARS-CoV-2 S protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F), His Tag (MALS verified)
SPN-C52Hg-sds
SPN-C52Hd SARS-CoV-2 SARS-CoV-2 S protein (F817P, A892P, A899P, A942P, K986P, V987P), His Tag (MALS verified)
SPN-C52Hd-sds
SPN-S52H6 SARS SARS S protein (R667A, K968P, V969P), His Tag (MALS verified)
SPN-S52H6-structure
SPN-S52H6-sds
SPN-C52H6 SARS-CoV-2 SARS-CoV-2 S protein (HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H), His Tag (MALS verified)
SPN-C52H6-sds
SPN-C52H7 SARS-CoV-2 SARS-CoV-2 S protein, His Tag, Super stable trimer (MALS verified)
SPN-C52H7-sds
MBS-K015 SARS-CoV-2 SARS-CoV-2 Spike Trimer-coupled Magnetic Beads
MBS-K016 SARS-CoV-2 SARS-CoV-2 Spike Trimer (D614G)-coupled Magnetic Beads
SPN-C82E3 SARS-CoV-2 Biotinylated SARS-CoV-2 S protein (D614G), His,Avitag™, Super stable trimer (MALS verified)
SPN-C82E3-sds
SPN-C52H3 SARS-CoV-2 SARS-CoV-2 S protein (D614G), His Tag, Super stable trimer (MALS verified)
SPN-C52H3-sds
SPN-C52H9 SARS-CoV-2 SARS-CoV-2 S protein, His Tag, Super stable trimer (MALS verified)
SPN-C52H9-sds
SPN-C82E9 SARS-CoV-2 Biotinylated SARS-CoV-2 S protein, His,Avitag™, Super stable trimer (MALS verified)
SPN-C82E9-sds

Part of Bioactivity data

SPN-C52Hk-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human ACE2, Fc Tag (Cat. No. AC2-H5257) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind SARS-CoV-2 S protein trimer, His Tag (Cat. No. SPN-C52Hk) with an affinity constant of 1.12 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
SPN-C52Hg-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human ACE2, Fc Tag (Cat. No. AC2-H5257) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind SARS-CoV-2 S protein, His Tag (Cat. No. SPN-C52Hg) with an affinity constant of 1.78 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

Customer Reviews

Synonym Name

Spike,S protein,Spike glycoprotein,S glycoprotein

Background

The newly identified 2019 novel coronavirus (SARS-CoV-2) has posed a serious threat to human health. Currently, there is no specific treatment for COVID-19. It is urgent to develop the SARS-CoV-2 inhibitors, for example vaccines and therapeutic antibodies and small molecular compounds against COVID-19.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Brodalumab IL-17R mAb; MEDI-6365; KHK-4827; AMG-827 Approved Amgen Inc Siliq, Lumicef, Kyntheum, 立美芙 Mainland China Plaque psoriasis Kyowa Kirin 2016-07-04 Arthritis, Rheumatoid; Spondylitis, Ankylosing; Scleroderma, Systemic; Psoriasis; Asthma; Arthritis, Psoriatic; Crohn Disease; Plaque psoriasis Details
Brodalumab IL-17R mAb; MEDI-6365; KHK-4827; AMG-827 Approved Amgen Inc Siliq, Lumicef, Kyntheum, 立美芙 Mainland China Plaque psoriasis Kyowa Kirin 2016-07-04 Arthritis, Rheumatoid; Spondylitis, Ankylosing; Scleroderma, Systemic; Psoriasis; Asthma; Arthritis, Psoriatic; Crohn Disease; Plaque psoriasis Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
LY-3114062 LY3114062; LY-3114062 Phase 1 Clinical Eli Lilly And Company Arthritis Details
S-011806 S-011806 Phase 1 Clinical Psoriasis Details
XCUR-17 XCUR-17 Phase 1 Clinical Exicure Psoriasis Details
LY-3114062 LY3114062; LY-3114062 Phase 1 Clinical Eli Lilly And Company Arthritis Details
S-011806 S-011806 Phase 1 Clinical Psoriasis Details
XCUR-17 XCUR-17 Phase 1 Clinical Exicure Psoriasis Details

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