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Llama IgG Fc Fusion Proteins - uniquely designed for llama immunization

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The single domain antibody was originally discovered in camels back in 1993. This new class of antibody is heavy chain only, containing a single variable domain (VHH) and two constant domains (CH2, CH3). This rare form of antibody has following unique advantages, which makes it an intriguing alternative to the conventional antibodies when it comes to therapeutic use.

First, because of its small size, these nanobodies are known to be able to reach to the cryptic epitopes of the targets normally not accessible by the much larger traditional antibodies. The stability of these antibodies is much better than the traditional antibodies, which makes it possible to be delivered through oral and maybe ocular routes, in addition to intravenous and subcutaneous injection. The nanobodies can also be easily conjugated with cell-killing agents if needed. Last but not least, from manufacturing standpoint, nanobodies are much easier to produce from a variety of hosts.

In October 2017, Belgium-based pharmaceutical company Ablynx reported positive results for its first-in-class nanobody drug caplacizumab from a phase III trial on acquired thrombotic thrombocytopenic purpura (aTTP) patients. This success clearly proves the potential for nanobody drugs.

The general process for producing VHH

ACROBiosystems provides a unique portfolio of llama lgG Fc tagged recombinant antigens, which are uniquely designed for llama immunization.

Key Features

  • The llama IgG Fc can promote protein dimerization to enhance immunogenicity

  • The tag has low immunogenicity

  • Long half-life and good stability

  • High purity (Fig 1)

  • High activity (Fig 2)

  • Low endotoxin (less than 10 EU/mg)

Performance of proteins conjugated with llama IgG Fc tag

Human PD-1, Llama IgG2b Fc Tag

Fig. 1 Human PD-1, Llama IgG2b Fc Tag, low endotoxin (Cat. No. PD1-H5259) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.

Immobilized Human BAFF

Fig. 2 Immobilized Human BAFF, His Tag (Cat. No. BAF-H5248) at 5 μg/mL (100 μL/well) can bind Human BCMA, Llama IgG2b Fc Tag (Cat. No. BCA-H5259) with a linear range of 0.02-0.4 ng/mL.

Product list of proteins conjugated with llama IgG Fc tag (Exclusive)

MoleculeCat. No.Product DescriptionStructure
BCMABCA-H5259Human BCMA, Llama IgG2b Fc Tag, low endotoxin
CD19CD9-H5250Human CD19 (20-291), Llama IgG2b Fc Tag, low endotoxin
CD30TN8-H5250Human CD30, Llama IgG2b Fc Tag, low endotoxin
CD38CD8-H5252Human CD38, Llama IgG2b Fc Tag, low endotoxin
CD47CD7-H5251Human CD47, Llama IgG2b Fc Tag, low endotoxin
LAG-3LA3-H525cHuman LAG-3, Llama IgG2b Fc Tag, low endotoxin
PD-1PD1-H5259Human PD-1, Llama IgG2b Fc Tag, low endotoxin
PD-L1PDL-H5250Human PD-L1, Llama IgG2b Fc Tag, low endotoxin
Siglec-2SI2-H525aHuman Siglec-2, Llama IgG2b Fc Tag, low endotoxin
Siglec-3CD3-H5259Human Siglec-3, Llama IgG2b Fc Tag, low endotoxin
Glypican 3GP3-H5257Human Glypican 3, Llama IgG2b Fc Tag, low endotoxin
Glypican 3GP3-C5259Cynomolgus Glypican 3, Llama IgG2b Fc Tag, low endotoxin
Mucin-1MU1-H5255Human Mucin-1, Llama IgG2b Fc Tag, low endotoxin
BAFFRBAR-H5258Human BAFFR, Llama IgG2b Fc Tag, low endotoxin
NKp46NC1-H5255Human NKp46, Llama IgG2b Fc Tag
CD7CD7-H5258Human CD7, Llama IgG2b Fc Tag
IL-3 R alphaILA-H5255Human IL-3 R alpha, Llama IgG2b Fc Tag, low endotoxin
IgG2b FcIGB-L5204Llama IgG2b Fc Protein, Tag Free
CD3E & CD3DCDD-C5259Cynomolgus CD3E&CD3D Heterodimer Protein, Llama Fc&Llama Fc, low endotoxin
CD3E & CD3DCDD-H5258Human CD3E&CD3D Heterodimer Protein, Llama Fc&Llama Fc, low endotoxin

For subsequent biopanning of phage display library, we recommend the corresponding biotinylated protein, which can be coated on Streptavidin-covered surface, for rapid high-throughput screening.

Product list of recommended biotinylated proteins

MoleculeCat. No.Product DescriptionStructure
BCMABC7-H82F0Biotinylated Human BCMA / TNFRSF17 Protein, Fc Tag, Avi Tag (Avitag™)
CD30CD0-H82E6Biotinylated Human CD30 / TNFRSF8 Protein, Avi Tag (Avitag™)
CD38CD8-H82E7Biotinylated Human CD38 Protein, Avi Tag (Avitag™)
CD47CD7-H82E9Biotinylated Human CD47 Protein, Avi Tag (Avitag™)
LAG-3LA3-H82F3Biotinylated Human LAG-3, Mouse IgG2a Fc Tag, (Avitag™)
PD-1PD1-H82E4Biotinylated Human PD-1(recommended for biopanning)
PD-L1PD1-H82E5Biotinylated Human PD-L1 / B7-H1 (recommended for biopanning), Avi Tag (Avitag™)
Siglec-2SI2-H82F8Biotinylated Human Siglec-2, Fc Tag, (Avitag™)
Siglec-3CD3-H82E7Biotinylated Human Siglec-3 / CD33 Protein, Avi Tag (Avitag™)

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